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Omega-3 polyunsaturated fatty acids and anxiety disorders.
Prostaglandins Leukot Essent Fatty Acids. 2009 Nov-Dec; 81(5-6):309-12.PL

Abstract

Anxiety disorders are a common group of psychiatric illnesses which have significant personal, family and societal costs. Current treatments have limited efficacy in many patients highlighting a need for new therapeutic approaches to be explored. Anxiety disorders exhibit marked comorbity with mood disorders suggesting the existence of mechanistic similarities. Such a notion is supported by observations that some conventional pharmacotherapies are both effective antidepressants and anxiolytics. As such, given that omega-3 PUFA supplementation may be effective in the treatment of major depressive disorder it is reasonable to propose that they may also possess anxiolytic properties. Experimental data in support of such a hypothesis is currently lacking although reduced abundance of omega-3 PUFA have been reported in patients with anxiety, while supplementation with omega-3 PUFA appears to inhibit activation of the HPA axis and can ameliorate some of the symptoms of anxiety. Clinical investigations carried out to date have, however, involved small numbers of participants. Larger trials using a variety of omega-3 PUFA species in clinically well-defined patients with anxiety will be required to demonstrate a therapeutic role for omega-3 PUFA in these disorders. Given the excellent side effect profile of omega-3 PUFA as well as their strong theoretical rationale, such future trials appear justified.

Authors+Show Affiliations

Division of Medical Sciences, Northern Ontario School of Medicine and Department of Biology, Lakehead University, Thunder Bay, 955 Oliver Road, Ontario, Canada P7B5E1. brian.ross@normed.ca

Pub Type(s)

Evaluation Study
Journal Article
Review

Language

eng

PubMed ID

19906519

Citation

Ross, Brian M.. "Omega-3 Polyunsaturated Fatty Acids and Anxiety Disorders." Prostaglandins, Leukotrienes, and Essential Fatty Acids, vol. 81, no. 5-6, 2009, pp. 309-12.
Ross BM. Omega-3 polyunsaturated fatty acids and anxiety disorders. Prostaglandins Leukot Essent Fatty Acids. 2009;81(5-6):309-12.
Ross, B. M. (2009). Omega-3 polyunsaturated fatty acids and anxiety disorders. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 81(5-6), 309-12. https://doi.org/10.1016/j.plefa.2009.10.004
Ross BM. Omega-3 Polyunsaturated Fatty Acids and Anxiety Disorders. Prostaglandins Leukot Essent Fatty Acids. 2009 Nov-Dec;81(5-6):309-12. PubMed PMID: 19906519.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Omega-3 polyunsaturated fatty acids and anxiety disorders. A1 - Ross,Brian M, Y1 - 2009/11/10/ PY - 2009/10/06/received PY - 2009/10/13/accepted PY - 2009/11/13/entrez PY - 2009/11/13/pubmed PY - 2010/3/24/medline SP - 309 EP - 12 JF - Prostaglandins, leukotrienes, and essential fatty acids JO - Prostaglandins Leukot Essent Fatty Acids VL - 81 IS - 5-6 N2 - Anxiety disorders are a common group of psychiatric illnesses which have significant personal, family and societal costs. Current treatments have limited efficacy in many patients highlighting a need for new therapeutic approaches to be explored. Anxiety disorders exhibit marked comorbity with mood disorders suggesting the existence of mechanistic similarities. Such a notion is supported by observations that some conventional pharmacotherapies are both effective antidepressants and anxiolytics. As such, given that omega-3 PUFA supplementation may be effective in the treatment of major depressive disorder it is reasonable to propose that they may also possess anxiolytic properties. Experimental data in support of such a hypothesis is currently lacking although reduced abundance of omega-3 PUFA have been reported in patients with anxiety, while supplementation with omega-3 PUFA appears to inhibit activation of the HPA axis and can ameliorate some of the symptoms of anxiety. Clinical investigations carried out to date have, however, involved small numbers of participants. Larger trials using a variety of omega-3 PUFA species in clinically well-defined patients with anxiety will be required to demonstrate a therapeutic role for omega-3 PUFA in these disorders. Given the excellent side effect profile of omega-3 PUFA as well as their strong theoretical rationale, such future trials appear justified. SN - 1532-2823 UR - https://www.unboundmedicine.com/medline/citation/19906519/Omega_3_polyunsaturated_fatty_acids_and_anxiety_disorders_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0952-3278(09)00174-4 DB - PRIME DP - Unbound Medicine ER -