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Antiplatelet therapy in combination with rt-PA thrombolysis in ischemic stroke (ARTIS): rationale and design of a randomized controlled trial.
Cerebrovasc Dis. 2010; 29(1):79-81.CD

Abstract

BACKGROUND

Thrombolysis with recombinant tissue plasminogen activator (rt-PA) is currently the only approved acute therapy for ischemic stroke. After rt-PA-induced recanalization, reocclusion is observed in 20-34%, probably caused by platelet activation. In acute myocardial infarction, the combination of thrombolytic and antiplatelet therapy leads to a better outcome compared to thrombolytic treatment alone. In patients with acute ischemic stroke, several studies showed that those on antiplatelet treatment prior to rt-PA had an equal or even better outcome compared to patients without prior use of antiplatelet therapy, despite an increased risk of bleeding.

METHODS

We present the protocol of a multicenter randomized clinical trial (n = 800) investigating the effects of immediate addition of aspirin to rt-PA on poor outcome (modified Rankin score >2) in ischemic stroke patients.

CONCLUSION

This study will answer the question whether the combination of rt-PA and antiplatelet therapy improves the functional outcome in ischemic stroke patients.

Authors+Show Affiliations

Department of Neurology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands. s.m.zinkstok@amc.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19907167

Citation

Zinkstok, S M., et al. "Antiplatelet Therapy in Combination With rt-PA Thrombolysis in Ischemic Stroke (ARTIS): Rationale and Design of a Randomized Controlled Trial." Cerebrovascular Diseases (Basel, Switzerland), vol. 29, no. 1, 2010, pp. 79-81.
Zinkstok SM, Vermeulen M, Stam J, et al. Antiplatelet therapy in combination with rt-PA thrombolysis in ischemic stroke (ARTIS): rationale and design of a randomized controlled trial. Cerebrovasc Dis. 2010;29(1):79-81.
Zinkstok, S. M., Vermeulen, M., Stam, J., de Haan, R. J., & Roos, Y. B. (2010). Antiplatelet therapy in combination with rt-PA thrombolysis in ischemic stroke (ARTIS): rationale and design of a randomized controlled trial. Cerebrovascular Diseases (Basel, Switzerland), 29(1), 79-81. https://doi.org/10.1159/000256651
Zinkstok SM, et al. Antiplatelet Therapy in Combination With rt-PA Thrombolysis in Ischemic Stroke (ARTIS): Rationale and Design of a Randomized Controlled Trial. Cerebrovasc Dis. 2010;29(1):79-81. PubMed PMID: 19907167.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antiplatelet therapy in combination with rt-PA thrombolysis in ischemic stroke (ARTIS): rationale and design of a randomized controlled trial. AU - Zinkstok,S M, AU - Vermeulen,M, AU - Stam,J, AU - de Haan,R J, AU - Roos,Y B, Y1 - 2009/11/10/ PY - 2009/04/14/received PY - 2009/08/25/accepted PY - 2009/11/13/entrez PY - 2009/11/13/pubmed PY - 2010/2/23/medline SP - 79 EP - 81 JF - Cerebrovascular diseases (Basel, Switzerland) JO - Cerebrovasc. Dis. VL - 29 IS - 1 N2 - BACKGROUND: Thrombolysis with recombinant tissue plasminogen activator (rt-PA) is currently the only approved acute therapy for ischemic stroke. After rt-PA-induced recanalization, reocclusion is observed in 20-34%, probably caused by platelet activation. In acute myocardial infarction, the combination of thrombolytic and antiplatelet therapy leads to a better outcome compared to thrombolytic treatment alone. In patients with acute ischemic stroke, several studies showed that those on antiplatelet treatment prior to rt-PA had an equal or even better outcome compared to patients without prior use of antiplatelet therapy, despite an increased risk of bleeding. METHODS: We present the protocol of a multicenter randomized clinical trial (n = 800) investigating the effects of immediate addition of aspirin to rt-PA on poor outcome (modified Rankin score >2) in ischemic stroke patients. CONCLUSION: This study will answer the question whether the combination of rt-PA and antiplatelet therapy improves the functional outcome in ischemic stroke patients. SN - 1421-9786 UR - https://www.unboundmedicine.com/medline/citation/19907167/Antiplatelet_therapy_in_combination_with_rt_PA_thrombolysis_in_ischemic_stroke__ARTIS_:_rationale_and_design_of_a_randomized_controlled_trial_ L2 - https://www.karger.com?DOI=10.1159/000256651 DB - PRIME DP - Unbound Medicine ER -