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Diffuse alveolar hemorrhage as an unusual presentation of systemic lupus erythematosus.

Abstract

Diffuse alveolar hemorrhage (DAH) is rarely seen in patients with systemic lupus erythematosus (SLE), often associated with a poor outcome. It almost affects young women and it is an unusual initial manifestation of SLE. We report a case of SLE presenting with DAH. The patient was a male. He had no history of photosensitivity, malar rash, discoid rash, arthritis, and oral ulcer. Antinuclear antibody, and anti-double stranded DNA (dsDNA) were positive with very high titers, and serum complement levels (C3, C4) were low. He also had renal dysfunction and pericardial effusion. He was diagnosed as DAH due to SLE. He had to undergo hemodialysis for several weeks. DAH and renal dysfunction were improved with intensive treatment including corticosteroid, cyclophosphamide, and mycophenolate mophetil.

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  • Authors+Show Affiliations

    ,

    Department of Nephrology, Gulhane School of Medicine, Ankara, Turkey. dr.erkansengul@hotmail.com

    , , ,

    Source

    Rheumatology international 31:8 2011 Aug pg 1085-7

    MeSH

    Cyclophosphamide
    Diagnosis, Differential
    Glucocorticoids
    Hemorrhage
    Humans
    Immunosuppressive Agents
    Lung Diseases
    Lupus Erythematosus, Systemic
    Male
    Mycophenolic Acid
    Pulmonary Alveoli
    Renal Dialysis
    Treatment Outcome
    Young Adult

    Pub Type(s)

    Case Reports
    Journal Article

    Language

    eng

    PubMed ID

    19908046

    Citation

    Sengul, Erkan, et al. "Diffuse Alveolar Hemorrhage as an Unusual Presentation of Systemic Lupus Erythematosus." Rheumatology International, vol. 31, no. 8, 2011, pp. 1085-7.
    Sengul E, Eyıleten T, Ozcan A, et al. Diffuse alveolar hemorrhage as an unusual presentation of systemic lupus erythematosus. Rheumatol Int. 2011;31(8):1085-7.
    Sengul, E., Eyıleten, T., Ozcan, A., Yılmaz, M. I., & Yenıcesu, M. (2011). Diffuse alveolar hemorrhage as an unusual presentation of systemic lupus erythematosus. Rheumatology International, 31(8), pp. 1085-7. doi:10.1007/s00296-009-1227-6.
    Sengul E, et al. Diffuse Alveolar Hemorrhage as an Unusual Presentation of Systemic Lupus Erythematosus. Rheumatol Int. 2011;31(8):1085-7. PubMed PMID: 19908046.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Diffuse alveolar hemorrhage as an unusual presentation of systemic lupus erythematosus. AU - Sengul,Erkan, AU - Eyıleten,Tayfun, AU - Ozcan,Ayhan, AU - Yılmaz,Mahmut Ilker, AU - Yenıcesu,Mujdat, Y1 - 2009/10/27/ PY - 2009/08/20/received PY - 2009/10/07/accepted PY - 2009/11/13/entrez PY - 2009/11/13/pubmed PY - 2011/12/13/medline SP - 1085 EP - 7 JF - Rheumatology international JO - Rheumatol. Int. VL - 31 IS - 8 N2 - Diffuse alveolar hemorrhage (DAH) is rarely seen in patients with systemic lupus erythematosus (SLE), often associated with a poor outcome. It almost affects young women and it is an unusual initial manifestation of SLE. We report a case of SLE presenting with DAH. The patient was a male. He had no history of photosensitivity, malar rash, discoid rash, arthritis, and oral ulcer. Antinuclear antibody, and anti-double stranded DNA (dsDNA) were positive with very high titers, and serum complement levels (C3, C4) were low. He also had renal dysfunction and pericardial effusion. He was diagnosed as DAH due to SLE. He had to undergo hemodialysis for several weeks. DAH and renal dysfunction were improved with intensive treatment including corticosteroid, cyclophosphamide, and mycophenolate mophetil. SN - 1437-160X UR - https://www.unboundmedicine.com/medline/citation/19908046/Diffuse_alveolar_hemorrhage_as_an_unusual_presentation_of_systemic_lupus_erythematosus_ L2 - https://dx.doi.org/10.1007/s00296-009-1227-6 DB - PRIME DP - Unbound Medicine ER -