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Low risk of colorectal cancer and advanced adenomas more than 10 years after negative colonoscopy.
Gastroenterology 2010; 138(3):870-6G

Abstract

BACKGROUND & AIMS

Screening colonoscopy is an effective method to reduce the incidence of and mortality from colorectal cancer (CRC). There is little empirical evidence available about the optimal interval for screening, making this a subject of debate. We associated the prevalence of advanced colorectal neoplasms with time since negative colonoscopies.

METHODS

In a study of participants in the German colonoscopy screening program, we determined the prevalence of colorectal neoplasias detected at screening colonoscopy among subjects who had undergone a previous colonoscopy without detection of polyps (negative colonoscopy). Data were compared with that from subjects who had not received colonoscopies.

RESULTS

No CRCs were detected in participants who had a previous negative colonoscopy an average of 11.9 years previously (n = 553), compared with the 8.4 CRC cases expected based on age- and gender-specific prevalences among participants who had not received a colonoscopy (n = 2701; standardized prevalence ratio [SPR] = 0.00; 95% confidence interval [CI]: 0.00-0.55). Prevalence of advanced adenoma was also much lower among subjects who had previous colonoscopies (SPR = 0.42; 95% CI: 0.25-0.68). Adjusted prevalence ratios (95% CIs) for detecting an advanced adenoma were 0.38 (95% CI: 0.16-0.90), 0.34 (95% CI: 0.15-0.74), 0.38 (95% CI: 0.16-0.90), and 0.53 (95% CI: 0.27-1.04) among participants with a negative colonoscopy conducted 1-5, 6-10, 11-15, and >16 years ago, respectively, compared to participants with no previous colonoscopy.

CONCLUSIONS

The low risk of CRC and advanced adenomas after a negative colonoscopy supports suggestions that screening intervals be extended to > or =10 years.

Authors+Show Affiliations

Division of Clinical Epidemiology of Aging Research, German Cancer Research Center, Bergheimer Str. 20, D-69115 Heidelberg, Germany. h.brenner@dkfz-heidelberg.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19909750

Citation

Brenner, Hermann, et al. "Low Risk of Colorectal Cancer and Advanced Adenomas More Than 10 Years After Negative Colonoscopy." Gastroenterology, vol. 138, no. 3, 2010, pp. 870-6.
Brenner H, Haug U, Arndt V, et al. Low risk of colorectal cancer and advanced adenomas more than 10 years after negative colonoscopy. Gastroenterology. 2010;138(3):870-6.
Brenner, H., Haug, U., Arndt, V., Stegmaier, C., Altenhofen, L., & Hoffmeister, M. (2010). Low risk of colorectal cancer and advanced adenomas more than 10 years after negative colonoscopy. Gastroenterology, 138(3), pp. 870-6. doi:10.1053/j.gastro.2009.10.054.
Brenner H, et al. Low Risk of Colorectal Cancer and Advanced Adenomas More Than 10 Years After Negative Colonoscopy. Gastroenterology. 2010;138(3):870-6. PubMed PMID: 19909750.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low risk of colorectal cancer and advanced adenomas more than 10 years after negative colonoscopy. AU - Brenner,Hermann, AU - Haug,Ulrike, AU - Arndt,Volker, AU - Stegmaier,Christa, AU - Altenhofen,Lutz, AU - Hoffmeister,Michael, Y1 - 2009/11/10/ PY - 2009/07/03/received PY - 2009/10/26/revised PY - 2009/10/30/accepted PY - 2009/11/14/entrez PY - 2009/11/17/pubmed PY - 2010/3/26/medline SP - 870 EP - 6 JF - Gastroenterology JO - Gastroenterology VL - 138 IS - 3 N2 - BACKGROUND & AIMS: Screening colonoscopy is an effective method to reduce the incidence of and mortality from colorectal cancer (CRC). There is little empirical evidence available about the optimal interval for screening, making this a subject of debate. We associated the prevalence of advanced colorectal neoplasms with time since negative colonoscopies. METHODS: In a study of participants in the German colonoscopy screening program, we determined the prevalence of colorectal neoplasias detected at screening colonoscopy among subjects who had undergone a previous colonoscopy without detection of polyps (negative colonoscopy). Data were compared with that from subjects who had not received colonoscopies. RESULTS: No CRCs were detected in participants who had a previous negative colonoscopy an average of 11.9 years previously (n = 553), compared with the 8.4 CRC cases expected based on age- and gender-specific prevalences among participants who had not received a colonoscopy (n = 2701; standardized prevalence ratio [SPR] = 0.00; 95% confidence interval [CI]: 0.00-0.55). Prevalence of advanced adenoma was also much lower among subjects who had previous colonoscopies (SPR = 0.42; 95% CI: 0.25-0.68). Adjusted prevalence ratios (95% CIs) for detecting an advanced adenoma were 0.38 (95% CI: 0.16-0.90), 0.34 (95% CI: 0.15-0.74), 0.38 (95% CI: 0.16-0.90), and 0.53 (95% CI: 0.27-1.04) among participants with a negative colonoscopy conducted 1-5, 6-10, 11-15, and >16 years ago, respectively, compared to participants with no previous colonoscopy. CONCLUSIONS: The low risk of CRC and advanced adenomas after a negative colonoscopy supports suggestions that screening intervals be extended to > or =10 years. SN - 1528-0012 UR - https://www.unboundmedicine.com/medline/citation/19909750/Low_risk_of_colorectal_cancer_and_advanced_adenomas_more_than_10_years_after_negative_colonoscopy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0016-5085(09)01953-2 DB - PRIME DP - Unbound Medicine ER -