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Chronic dopaminergic stimulation in Parkinson's disease: from dyskinesias to impulse control disorders.
Lancet Neurol. 2009 Dec; 8(12):1140-9.LN

Abstract

Dopamine is an essential neurotransmitter for many brain functions, and its dysfunction has been implicated in both neurological and psychiatric disorders. Parkinson's disease is an archetypal disorder of dopamine dysfunction characterised by motor, cognitive, behavioural, and autonomic symptoms. While effective for motor symptoms, dopamine replacement therapy is associated not only with motor side-effects, such as levodopa-induced dyskinesia, but also behavioural side-effects such as impulse control disorders (eg, pathological gambling and shopping, binge eating, and hypersexuality), punding (ie, abnormal repetitive non-goal oriented behaviours), and compulsive medication use. We review clinical features, overlapping molecular mechanisms, and a specific cognitive mechanism of habit learning that might underlie these behaviours. We integrate these mechanisms with the emerging view of the basal ganglia as a distributive system involved in the selection and facilitation of movements, acts, and emotions.

Authors+Show Affiliations

Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, UK. voonval@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19909912

Citation

Voon, Valerie, et al. "Chronic Dopaminergic Stimulation in Parkinson's Disease: From Dyskinesias to Impulse Control Disorders." The Lancet. Neurology, vol. 8, no. 12, 2009, pp. 1140-9.
Voon V, Fernagut PO, Wickens J, et al. Chronic dopaminergic stimulation in Parkinson's disease: from dyskinesias to impulse control disorders. Lancet Neurol. 2009;8(12):1140-9.
Voon, V., Fernagut, P. O., Wickens, J., Baunez, C., Rodriguez, M., Pavon, N., Juncos, J. L., Obeso, J. A., & Bezard, E. (2009). Chronic dopaminergic stimulation in Parkinson's disease: from dyskinesias to impulse control disorders. The Lancet. Neurology, 8(12), 1140-9. https://doi.org/10.1016/S1474-4422(09)70287-X
Voon V, et al. Chronic Dopaminergic Stimulation in Parkinson's Disease: From Dyskinesias to Impulse Control Disorders. Lancet Neurol. 2009;8(12):1140-9. PubMed PMID: 19909912.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chronic dopaminergic stimulation in Parkinson's disease: from dyskinesias to impulse control disorders. AU - Voon,Valerie, AU - Fernagut,Pierre-Olivier, AU - Wickens,Jeff, AU - Baunez,Christelle, AU - Rodriguez,Manuel, AU - Pavon,Nancy, AU - Juncos,Jorge L, AU - Obeso,José A, AU - Bezard,Erwan, PY - 2009/11/14/entrez PY - 2009/11/17/pubmed PY - 2009/12/16/medline SP - 1140 EP - 9 JF - The Lancet. Neurology JO - Lancet Neurol VL - 8 IS - 12 N2 - Dopamine is an essential neurotransmitter for many brain functions, and its dysfunction has been implicated in both neurological and psychiatric disorders. Parkinson's disease is an archetypal disorder of dopamine dysfunction characterised by motor, cognitive, behavioural, and autonomic symptoms. While effective for motor symptoms, dopamine replacement therapy is associated not only with motor side-effects, such as levodopa-induced dyskinesia, but also behavioural side-effects such as impulse control disorders (eg, pathological gambling and shopping, binge eating, and hypersexuality), punding (ie, abnormal repetitive non-goal oriented behaviours), and compulsive medication use. We review clinical features, overlapping molecular mechanisms, and a specific cognitive mechanism of habit learning that might underlie these behaviours. We integrate these mechanisms with the emerging view of the basal ganglia as a distributive system involved in the selection and facilitation of movements, acts, and emotions. SN - 1474-4465 UR - https://www.unboundmedicine.com/medline/citation/19909912/Chronic_dopaminergic_stimulation_in_Parkinson's_disease:_from_dyskinesias_to_impulse_control_disorders_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1474-4422(09)70287-X DB - PRIME DP - Unbound Medicine ER -