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Sporadic cases of acute autochthonous hepatitis E virus infection in Southwest Germany.
J Clin Virol. 2010 Jan; 47(1):89-92.JC

Abstract

Hepatitis E infection is usually a self-limiting disease and an important cause of acute hepatitis in tropical and subtropical regions where the virus is endemic. In industrialized countries, sporadic cases of acute hepatitis E virus (HEV) infections have been described and the number of documented autochthonous infections seems to be increasing. We report three sporadic cases of autochthonous hepatitis E infections in Southwestern Germany which presented at our university hospital within two years. All cases were men who presented with acute hepatitis, icterus and elevated liver. In case 1 and case 2, liver biopsy revealed acute hepatitis, both patients were positive for anti-HEV antibodies, case 1 was also positive for HEV RNA with a viral load of 3.0 x 10(3)copies/ml in serum. In case 3, anti-HEV antibodies were detectable and HEV RNA was detected in serum (4.3 x 10(3)copies/ml) and stool (1.4 x 10(6)copies/ml). None of the patients had a recent travel history outside Germany and close contact to animals has been denied. HEV sequence analysis of two patients revealed genotype 3 with homologies to other European isolates and isolates from swine. Thus the source of infection remains unclear. Hepatitis E should be considered in differential diagnosis in patients with unexplained hepatitis and patients with acute hepatitis, whatever their age or travel history might be, should be tested for HEV.

Authors+Show Affiliations

Department of Internal Medicine IV, University of Heidelberg, Heidelberg, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

19910247

Citation

Brost, S, et al. "Sporadic Cases of Acute Autochthonous Hepatitis E Virus Infection in Southwest Germany." Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, vol. 47, no. 1, 2010, pp. 89-92.
Brost S, Wenzel JJ, Ganten TM, et al. Sporadic cases of acute autochthonous hepatitis E virus infection in Southwest Germany. J Clin Virol. 2010;47(1):89-92.
Brost, S., Wenzel, J. J., Ganten, T. M., Filser, M., Flechtenmacher, C., Boehm, S., Astani, A., Jilg, W., Zeier, M., & Schnitzler, P. (2010). Sporadic cases of acute autochthonous hepatitis E virus infection in Southwest Germany. Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology, 47(1), 89-92. https://doi.org/10.1016/j.jcv.2009.10.011
Brost S, et al. Sporadic Cases of Acute Autochthonous Hepatitis E Virus Infection in Southwest Germany. J Clin Virol. 2010;47(1):89-92. PubMed PMID: 19910247.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sporadic cases of acute autochthonous hepatitis E virus infection in Southwest Germany. AU - Brost,S, AU - Wenzel,J J, AU - Ganten,T M, AU - Filser,M, AU - Flechtenmacher,C, AU - Boehm,S, AU - Astani,A, AU - Jilg,W, AU - Zeier,M, AU - Schnitzler,P, Y1 - 2009/11/11/ PY - 2009/07/15/received PY - 2009/10/05/revised PY - 2009/10/07/accepted PY - 2009/11/14/entrez PY - 2009/11/17/pubmed PY - 2010/5/5/medline SP - 89 EP - 92 JF - Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology JO - J Clin Virol VL - 47 IS - 1 N2 - Hepatitis E infection is usually a self-limiting disease and an important cause of acute hepatitis in tropical and subtropical regions where the virus is endemic. In industrialized countries, sporadic cases of acute hepatitis E virus (HEV) infections have been described and the number of documented autochthonous infections seems to be increasing. We report three sporadic cases of autochthonous hepatitis E infections in Southwestern Germany which presented at our university hospital within two years. All cases were men who presented with acute hepatitis, icterus and elevated liver. In case 1 and case 2, liver biopsy revealed acute hepatitis, both patients were positive for anti-HEV antibodies, case 1 was also positive for HEV RNA with a viral load of 3.0 x 10(3)copies/ml in serum. In case 3, anti-HEV antibodies were detectable and HEV RNA was detected in serum (4.3 x 10(3)copies/ml) and stool (1.4 x 10(6)copies/ml). None of the patients had a recent travel history outside Germany and close contact to animals has been denied. HEV sequence analysis of two patients revealed genotype 3 with homologies to other European isolates and isolates from swine. Thus the source of infection remains unclear. Hepatitis E should be considered in differential diagnosis in patients with unexplained hepatitis and patients with acute hepatitis, whatever their age or travel history might be, should be tested for HEV. SN - 1873-5967 UR - https://www.unboundmedicine.com/medline/citation/19910247/Sporadic_cases_of_acute_autochthonous_hepatitis_E_virus_infection_in_Southwest_Germany_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1386-6532(09)00501-0 DB - PRIME DP - Unbound Medicine ER -