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Elevations in ostensibly anabolic hormones with resistance exercise enhance neither training-induced muscle hypertrophy nor strength of the elbow flexors.
J Appl Physiol (1985). 2010 Jan; 108(1):60-7.JA

Abstract

The aim of our study was to determine whether resistance exercise-induced elevations in endogenous hormones enhance muscle strength and hypertrophy with training. Twelve healthy young men (21.8 +/- 1.2 yr, body mass index = 23.1 +/- 0.6 kg/m(2)) trained their elbow flexors independently for 15 wk on separate days and under different hormonal milieu. In one training condition, participants performed isolated arm curl exercise designed to maintain basal hormone concentrations (low hormone, LH); in the other training condition, participants performed identical arm exercise to the LH condition followed immediately by a high volume of leg resistance exercise to elicit a large increase in endogenous hormones (high hormone, HH). There was no elevation in serum growth hormone (GH), insulin-like growth factor (IGF-1), or testosterone after the LH protocol but significant (P < 0.001) elevations in these hormones immediately and 15 and 30 min after the HH protocol. The hormone responses elicited by each respective exercise protocol late in the training period were similar to the response elicited early in the training period, indicating that a divergent postexercise hormone response was maintained over the training period. Muscle cross-sectional area (CSA) increased by 12% in LH and 10% in HH (P < 0.001) with no difference between conditions (condition x training interaction, P = 0.25). Similarly, type I (P < 0.01) and type II (P < 0.001) muscle fiber CSA increased with training with no effect of hormone elevation in the HH condition. Strength increased in both arms, but the increase was not different between the LH and HH conditions. We conclude that exposure of loaded muscle to acute exercise-induced elevations in endogenous anabolic hormones enhances neither muscle hypertrophy nor strength with resistance training in young men.

Authors+Show Affiliations

Exercise Metabolism Research Group, Dept. of Kinesiology, McMaster Univ., Hamilton, ON L8S4K1 Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19910330

Citation

West, Daniel W D., et al. "Elevations in Ostensibly Anabolic Hormones With Resistance Exercise Enhance Neither Training-induced Muscle Hypertrophy nor Strength of the Elbow Flexors." Journal of Applied Physiology (Bethesda, Md. : 1985), vol. 108, no. 1, 2010, pp. 60-7.
West DW, Burd NA, Tang JE, et al. Elevations in ostensibly anabolic hormones with resistance exercise enhance neither training-induced muscle hypertrophy nor strength of the elbow flexors. J Appl Physiol. 2010;108(1):60-7.
West, D. W., Burd, N. A., Tang, J. E., Moore, D. R., Staples, A. W., Holwerda, A. M., Baker, S. K., & Phillips, S. M. (2010). Elevations in ostensibly anabolic hormones with resistance exercise enhance neither training-induced muscle hypertrophy nor strength of the elbow flexors. Journal of Applied Physiology (Bethesda, Md. : 1985), 108(1), 60-7. https://doi.org/10.1152/japplphysiol.01147.2009
West DW, et al. Elevations in Ostensibly Anabolic Hormones With Resistance Exercise Enhance Neither Training-induced Muscle Hypertrophy nor Strength of the Elbow Flexors. J Appl Physiol. 2010;108(1):60-7. PubMed PMID: 19910330.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Elevations in ostensibly anabolic hormones with resistance exercise enhance neither training-induced muscle hypertrophy nor strength of the elbow flexors. AU - West,Daniel W D, AU - Burd,Nicholas A, AU - Tang,Jason E, AU - Moore,Daniel R, AU - Staples,Aaron W, AU - Holwerda,Andrew M, AU - Baker,Steven K, AU - Phillips,Stuart M, Y1 - 2009/11/12/ PY - 2009/11/14/entrez PY - 2009/11/17/pubmed PY - 2010/3/18/medline SP - 60 EP - 7 JF - Journal of applied physiology (Bethesda, Md. : 1985) JO - J. Appl. Physiol. VL - 108 IS - 1 N2 - The aim of our study was to determine whether resistance exercise-induced elevations in endogenous hormones enhance muscle strength and hypertrophy with training. Twelve healthy young men (21.8 +/- 1.2 yr, body mass index = 23.1 +/- 0.6 kg/m(2)) trained their elbow flexors independently for 15 wk on separate days and under different hormonal milieu. In one training condition, participants performed isolated arm curl exercise designed to maintain basal hormone concentrations (low hormone, LH); in the other training condition, participants performed identical arm exercise to the LH condition followed immediately by a high volume of leg resistance exercise to elicit a large increase in endogenous hormones (high hormone, HH). There was no elevation in serum growth hormone (GH), insulin-like growth factor (IGF-1), or testosterone after the LH protocol but significant (P < 0.001) elevations in these hormones immediately and 15 and 30 min after the HH protocol. The hormone responses elicited by each respective exercise protocol late in the training period were similar to the response elicited early in the training period, indicating that a divergent postexercise hormone response was maintained over the training period. Muscle cross-sectional area (CSA) increased by 12% in LH and 10% in HH (P < 0.001) with no difference between conditions (condition x training interaction, P = 0.25). Similarly, type I (P < 0.01) and type II (P < 0.001) muscle fiber CSA increased with training with no effect of hormone elevation in the HH condition. Strength increased in both arms, but the increase was not different between the LH and HH conditions. We conclude that exposure of loaded muscle to acute exercise-induced elevations in endogenous anabolic hormones enhances neither muscle hypertrophy nor strength with resistance training in young men. SN - 1522-1601 UR - https://www.unboundmedicine.com/medline/citation/19910330/Elevations_in_ostensibly_anabolic_hormones_with_resistance_exercise_enhance_neither_training_induced_muscle_hypertrophy_nor_strength_of_the_elbow_flexors_ L2 - http://journals.physiology.org/doi/full/10.1152/japplphysiol.01147.2009?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -