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Infants of human immunodeficiency virus type 1-infected women in rural south India: feeding patterns and risk of mother-to-child transmission.
Pediatr Infect Dis J 2010; 29(1):14-7PI

Abstract

BACKGROUND

We assessed the infant feeding choices of HIV-1-infected women in rural Tamil Nadu, India, and risk factors for mother-to-child transmission of HIV-1.

METHODS

The study population comprised live born infants of HIV-1-infected women from the antenatal clinics of 2 public hospitals in rural Tamil Nadu, India who were enrolled in a prospective cohort study. All women enrolled in the cohort were offered antiretroviral prophylaxis and infant feeding counseling based on WHO/UNAIDS/UNICEF training materials. Infant study visits were scheduled at birth (within the first 24 hours of life), at 1 week, 1 month, and 2 months after birth, and then every 2 months between 4 and 12 months of age.

RESULTS

One-third of women did not breast-feed their infants. Of those who initiated breast-feeding, the median duration of breast-feeding was approximately 3 months. Among those infants who initiated breast-feeding, the proportion exclusively breast-feeding declined from approximately 70% during the first week of life to 0% by the 8 month visit. The observed rate of mother-to-child transmission of HIV-1 in the entire cohort was 6.5% (95% CI: 1.4%-17.9%). The observed HIV-1 incidence among breast-fed infants was 0% (95% CI: 0%-8.9%).

CONCLUSION

The overall transmission rate was relatively low, suggesting effectiveness of antiretroviral transmission prophylaxis. The infant feeding choices made may reflect knowledge gained through the educational program and infant feeding counseling provided. Ensuring HIV-1-infected women receive appropriate HIV-1 treatment (for those who meet criteria for treatment) and access to known efficacious interventions to prevent mother-to-child transmission of HIV-1, are essential.

Authors+Show Affiliations

Pediatric, Adolescent, and Maternal AIDS Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health Executive Building, Room 4B11C, 6100 Executive Boulevard MSC 7510, Bethesda, MD 20892-7510. jennifer_read@nih.govNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

19910839

Citation

Read, Jennifer S., et al. "Infants of Human Immunodeficiency Virus Type 1-infected Women in Rural South India: Feeding Patterns and Risk of Mother-to-child Transmission." The Pediatric Infectious Disease Journal, vol. 29, no. 1, 2010, pp. 14-7.
Read JS, Samuel NM, Srijayanth P, et al. Infants of human immunodeficiency virus type 1-infected women in rural south India: feeding patterns and risk of mother-to-child transmission. Pediatr Infect Dis J. 2010;29(1):14-7.
Read, J. S., Samuel, N. M., Srijayanth, P., Dharmarajan, S., Van Hook, H. M., Jacob, M., ... Stoszek, S. K. (2010). Infants of human immunodeficiency virus type 1-infected women in rural south India: feeding patterns and risk of mother-to-child transmission. The Pediatric Infectious Disease Journal, 29(1), pp. 14-7. doi:10.1097/INF.0b013e3181b20ffc.
Read JS, et al. Infants of Human Immunodeficiency Virus Type 1-infected Women in Rural South India: Feeding Patterns and Risk of Mother-to-child Transmission. Pediatr Infect Dis J. 2010;29(1):14-7. PubMed PMID: 19910839.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Infants of human immunodeficiency virus type 1-infected women in rural south India: feeding patterns and risk of mother-to-child transmission. AU - Read,Jennifer S, AU - Samuel,N M, AU - Srijayanth,Parameshwari, AU - Dharmarajan,Shoba, AU - Van Hook,Hannah M, AU - Jacob,Mini, AU - Junankar,Viju, AU - Bethel,James, AU - Yu,Eunice, AU - Stoszek,Sonia K, AU - ,, PY - 2009/11/14/entrez PY - 2009/11/17/pubmed PY - 2010/2/27/medline SP - 14 EP - 7 JF - The Pediatric infectious disease journal JO - Pediatr. Infect. Dis. J. VL - 29 IS - 1 N2 - BACKGROUND: We assessed the infant feeding choices of HIV-1-infected women in rural Tamil Nadu, India, and risk factors for mother-to-child transmission of HIV-1. METHODS: The study population comprised live born infants of HIV-1-infected women from the antenatal clinics of 2 public hospitals in rural Tamil Nadu, India who were enrolled in a prospective cohort study. All women enrolled in the cohort were offered antiretroviral prophylaxis and infant feeding counseling based on WHO/UNAIDS/UNICEF training materials. Infant study visits were scheduled at birth (within the first 24 hours of life), at 1 week, 1 month, and 2 months after birth, and then every 2 months between 4 and 12 months of age. RESULTS: One-third of women did not breast-feed their infants. Of those who initiated breast-feeding, the median duration of breast-feeding was approximately 3 months. Among those infants who initiated breast-feeding, the proportion exclusively breast-feeding declined from approximately 70% during the first week of life to 0% by the 8 month visit. The observed rate of mother-to-child transmission of HIV-1 in the entire cohort was 6.5% (95% CI: 1.4%-17.9%). The observed HIV-1 incidence among breast-fed infants was 0% (95% CI: 0%-8.9%). CONCLUSION: The overall transmission rate was relatively low, suggesting effectiveness of antiretroviral transmission prophylaxis. The infant feeding choices made may reflect knowledge gained through the educational program and infant feeding counseling provided. Ensuring HIV-1-infected women receive appropriate HIV-1 treatment (for those who meet criteria for treatment) and access to known efficacious interventions to prevent mother-to-child transmission of HIV-1, are essential. SN - 1532-0987 UR - https://www.unboundmedicine.com/medline/citation/19910839/Infants_of_human_immunodeficiency_virus_type_1_infected_women_in_rural_south_India:_feeding_patterns_and_risk_of_mother_to_child_transmission_ L2 - http://Insights.ovid.com/pubmed?pmid=19910839 DB - PRIME DP - Unbound Medicine ER -