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Neutrophil count on admission predicts major in-hospital events in patients with a non-ST-segment elevation acute coronary syndrome.
Clin Cardiol 2009; 32(10):561-8CC

Abstract

BACKGROUND

Inflammation plays a key role in the pathogenesis of acute coronary syndromes (ACS). In this context we assessed neutrophil count as a predictor of major in-hospital events in patients admitted for a non-ST-segment elevation (NSTE) ACS.

METHODS

We measured neutrophils on admission in 160 patients with a NSTE ACS and we correlated their count with the incidence of a combined in-hospital end point including: cardiac death, acute heart failure, ST-segment elevation myocardial infarction, and recurrent myocardial ischemia.

RESULTS

Patients who had a major in-hospital event also had a higher neutrophil count (P = 0.02) and higher serum levels of troponin I (P = 0.04). In the univariate logistic regression analysis, in-hospital major events could be predicted by troponin I > 0.07 ng/mL (odds ratio [OR]: 5.65, 95% confidence interval [CI]: 1.26-25.32, P = 0.02), white blood cell count > 8650 cells/microL (OR: 2.68, 95% CI: 1.03-6.95, P = 0.04), neutrophil count > 6700 cells/microL (OR: 7.74, 95% CI: 2.79-21.47, P < 0.001), and C-reactive protein > 0.97 mg/dL (OR: 3.56, 95% CI: 1.13-11.19, P = 0.02). However, in multivariate regression, neutrophil count > 6700 cells/microL (OR: 6.52, 95% CI: 1.56-27.22, P = 0.01) was the only independent in-hospital prognostic factor.

CONCLUSIONS

In patients with a NSTE ACS of moderate or high risk, neutrophil count on admission may identify those who are at risk of having an adverse in-hospital outcome.

Authors+Show Affiliations

Euroclinic of Athens Greece, Athens, Greece. ilias.karabinos@lycos.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19911351

Citation

Karabinos, Ilias, et al. "Neutrophil Count On Admission Predicts Major In-hospital Events in Patients With a non-ST-segment Elevation Acute Coronary Syndrome." Clinical Cardiology, vol. 32, no. 10, 2009, pp. 561-8.
Karabinos I, Koulouris S, Kranidis A, et al. Neutrophil count on admission predicts major in-hospital events in patients with a non-ST-segment elevation acute coronary syndrome. Clin Cardiol. 2009;32(10):561-8.
Karabinos, I., Koulouris, S., Kranidis, A., Pastromas, S., Exadaktylos, N., & Kalofoutis, A. (2009). Neutrophil count on admission predicts major in-hospital events in patients with a non-ST-segment elevation acute coronary syndrome. Clinical Cardiology, 32(10), pp. 561-8. doi:10.1002/clc.20624.
Karabinos I, et al. Neutrophil Count On Admission Predicts Major In-hospital Events in Patients With a non-ST-segment Elevation Acute Coronary Syndrome. Clin Cardiol. 2009;32(10):561-8. PubMed PMID: 19911351.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neutrophil count on admission predicts major in-hospital events in patients with a non-ST-segment elevation acute coronary syndrome. AU - Karabinos,Ilias, AU - Koulouris,Spyridon, AU - Kranidis,Athanasios, AU - Pastromas,Socrates, AU - Exadaktylos,Nikolaos, AU - Kalofoutis,Anastasios, PY - 2009/11/14/entrez PY - 2009/11/17/pubmed PY - 2010/1/27/medline SP - 561 EP - 8 JF - Clinical cardiology JO - Clin Cardiol VL - 32 IS - 10 N2 - BACKGROUND: Inflammation plays a key role in the pathogenesis of acute coronary syndromes (ACS). In this context we assessed neutrophil count as a predictor of major in-hospital events in patients admitted for a non-ST-segment elevation (NSTE) ACS. METHODS: We measured neutrophils on admission in 160 patients with a NSTE ACS and we correlated their count with the incidence of a combined in-hospital end point including: cardiac death, acute heart failure, ST-segment elevation myocardial infarction, and recurrent myocardial ischemia. RESULTS: Patients who had a major in-hospital event also had a higher neutrophil count (P = 0.02) and higher serum levels of troponin I (P = 0.04). In the univariate logistic regression analysis, in-hospital major events could be predicted by troponin I > 0.07 ng/mL (odds ratio [OR]: 5.65, 95% confidence interval [CI]: 1.26-25.32, P = 0.02), white blood cell count > 8650 cells/microL (OR: 2.68, 95% CI: 1.03-6.95, P = 0.04), neutrophil count > 6700 cells/microL (OR: 7.74, 95% CI: 2.79-21.47, P < 0.001), and C-reactive protein > 0.97 mg/dL (OR: 3.56, 95% CI: 1.13-11.19, P = 0.02). However, in multivariate regression, neutrophil count > 6700 cells/microL (OR: 6.52, 95% CI: 1.56-27.22, P = 0.01) was the only independent in-hospital prognostic factor. CONCLUSIONS: In patients with a NSTE ACS of moderate or high risk, neutrophil count on admission may identify those who are at risk of having an adverse in-hospital outcome. SN - 1932-8737 UR - https://www.unboundmedicine.com/medline/citation/19911351/Neutrophil_count_on_admission_predicts_major_in_hospital_events_in_patients_with_a_non_ST_segment_elevation_acute_coronary_syndrome_ L2 - https://doi.org/10.1002/clc.20624 DB - PRIME DP - Unbound Medicine ER -