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Burst stimulation of the auditory cortex: a new form of neurostimulation for noise-like tinnitus suppression.
J Neurosurg. 2010 Jun; 112(6):1289-94.JN

Abstract

OBJECT

Tinnitus is an auditory phantom percept related to tonic and burst hyperactivity of the auditory system. Two parallel pathways supply auditory information to the cerebral cortex: the tonotopically organized lemniscal system, and the nontonotopic extralemniscal system, which fire in tonic and burst mode, respectively. Electrical cortex stimulation is a method capable of modulating activity of the human cortex by delivering stimuli in a tonic or burst way. Burst firing is shown to be more powerful in activating the cerebral cortex than tonic firing, and bursts may activate neurons that are not activated by tonic firing.

METHODS

Five patients with an implanted electrode on the auditory cortex were asked to rate their tinnitus distress and intensity on a visual analog scale before and after 40-Hz tonic and 40-Hz burst (5 pulses at 500 Hz) stimulation. All patients presented with both high-pitched pure tone and white noise components in their tinnitus.

RESULTS

A significantly better suppression for narrowband noise tinnitus with burst stimulation in comparison with tonic stimulation (Z = -2.03, p = 0.04) was found. For pure tone tinnitus, no difference was found between tonic and burst stimulation (Z = -0.58, p = 0.56). No significant effect was obtained for stimulation amplitude (Z = -1.21, p = 0.23) and electrical charge per pulse (Z = -0.67, p = 0.50) between tonic and burst stimulation. The electrical current delivery per second was significantly different (Z = -2.02, p = 0.04).

CONCLUSIONS

Burst stimulation is a new form of neurostimulation that might be helpful in treating symptoms that are intractable to conventional tonic stimulation. Further exploration of this new stimulation design is warranted.

Authors+Show Affiliations

BRAI2N, University Hospital Antwerp, Edegem, Belgium. dirk.de.ridder@uza.beNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19911891

Citation

De Ridder, Dirk, et al. "Burst Stimulation of the Auditory Cortex: a New Form of Neurostimulation for Noise-like Tinnitus Suppression." Journal of Neurosurgery, vol. 112, no. 6, 2010, pp. 1289-94.
De Ridder D, Vanneste S, van der Loo E, et al. Burst stimulation of the auditory cortex: a new form of neurostimulation for noise-like tinnitus suppression. J Neurosurg. 2010;112(6):1289-94.
De Ridder, D., Vanneste, S., van der Loo, E., Plazier, M., Menovsky, T., & van de Heyning, P. (2010). Burst stimulation of the auditory cortex: a new form of neurostimulation for noise-like tinnitus suppression. Journal of Neurosurgery, 112(6), 1289-94. https://doi.org/10.3171/2009.10.JNS09298
De Ridder D, et al. Burst Stimulation of the Auditory Cortex: a New Form of Neurostimulation for Noise-like Tinnitus Suppression. J Neurosurg. 2010;112(6):1289-94. PubMed PMID: 19911891.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Burst stimulation of the auditory cortex: a new form of neurostimulation for noise-like tinnitus suppression. AU - De Ridder,Dirk, AU - Vanneste,Sven, AU - van der Loo,Elsa, AU - Plazier,Mark, AU - Menovsky,Tomas, AU - van de Heyning,Paul, PY - 2009/11/17/entrez PY - 2009/11/17/pubmed PY - 2010/6/23/medline SP - 1289 EP - 94 JF - Journal of neurosurgery JO - J Neurosurg VL - 112 IS - 6 N2 - OBJECT: Tinnitus is an auditory phantom percept related to tonic and burst hyperactivity of the auditory system. Two parallel pathways supply auditory information to the cerebral cortex: the tonotopically organized lemniscal system, and the nontonotopic extralemniscal system, which fire in tonic and burst mode, respectively. Electrical cortex stimulation is a method capable of modulating activity of the human cortex by delivering stimuli in a tonic or burst way. Burst firing is shown to be more powerful in activating the cerebral cortex than tonic firing, and bursts may activate neurons that are not activated by tonic firing. METHODS: Five patients with an implanted electrode on the auditory cortex were asked to rate their tinnitus distress and intensity on a visual analog scale before and after 40-Hz tonic and 40-Hz burst (5 pulses at 500 Hz) stimulation. All patients presented with both high-pitched pure tone and white noise components in their tinnitus. RESULTS: A significantly better suppression for narrowband noise tinnitus with burst stimulation in comparison with tonic stimulation (Z = -2.03, p = 0.04) was found. For pure tone tinnitus, no difference was found between tonic and burst stimulation (Z = -0.58, p = 0.56). No significant effect was obtained for stimulation amplitude (Z = -1.21, p = 0.23) and electrical charge per pulse (Z = -0.67, p = 0.50) between tonic and burst stimulation. The electrical current delivery per second was significantly different (Z = -2.02, p = 0.04). CONCLUSIONS: Burst stimulation is a new form of neurostimulation that might be helpful in treating symptoms that are intractable to conventional tonic stimulation. Further exploration of this new stimulation design is warranted. SN - 1933-0693 UR - https://www.unboundmedicine.com/medline/citation/19911891/Burst_stimulation_of_the_auditory_cortex:_a_new_form_of_neurostimulation_for_noise_like_tinnitus_suppression_ L2 - https://thejns.org/doi/10.3171/2009.10.JNS09298 DB - PRIME DP - Unbound Medicine ER -