Tags

Type your tag names separated by a space and hit enter

Diagnosis of acute pulmonary histoplasmosis by antigen detection.
Clin Infect Dis. 2009 Dec 15; 49(12):1878-82.CI

Abstract

BACKGROUND

Antigen detection, which has proven useful in diagnosis of disseminated histoplasmosis, has not been studied in acute pulmonary histoplasmosis (APH). Because treatment is indicated in most patients with moderately severe or severe APH, antigen detection for rapid diagnosis could be helpful.

METHODS

Histoplasma antigen detection was evaluated in 130 patients with APH.

RESULTS

Antigenuria was detected in 64.6%, antigenemia in 68.6%, and antibody in 64.3%. If both urine and serum specimens were tested, antigen was detected in 82.8%, of which 45.8% had antigenemia only; and if both antigen and antibody were measured, results were positive in 93.3%, of which antigen only was positive in 35.7%.

CONCLUSIONS

Testing for antigenemia, antigenuria, and antibodies using the complement fixation test offers a sensitive, noninvasive method for diagnosis of APH.

Authors+Show Affiliations

MiraVista Diagnostics and MiraBella Technologies, Indianapolis, Indiana 46241, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19911965

Citation

Swartzentruber, S, et al. "Diagnosis of Acute Pulmonary Histoplasmosis By Antigen Detection." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 49, no. 12, 2009, pp. 1878-82.
Swartzentruber S, Rhodes L, Kurkjian K, et al. Diagnosis of acute pulmonary histoplasmosis by antigen detection. Clin Infect Dis. 2009;49(12):1878-82.
Swartzentruber, S., Rhodes, L., Kurkjian, K., Zahn, M., Brandt, M. E., Connolly, P., & Wheat, L. J. (2009). Diagnosis of acute pulmonary histoplasmosis by antigen detection. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 49(12), 1878-82. https://doi.org/10.1086/648421
Swartzentruber S, et al. Diagnosis of Acute Pulmonary Histoplasmosis By Antigen Detection. Clin Infect Dis. 2009 Dec 15;49(12):1878-82. PubMed PMID: 19911965.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnosis of acute pulmonary histoplasmosis by antigen detection. AU - Swartzentruber,S, AU - Rhodes,L, AU - Kurkjian,K, AU - Zahn,M, AU - Brandt,M E, AU - Connolly,P, AU - Wheat,L J, PY - 2009/11/17/entrez PY - 2009/11/17/pubmed PY - 2010/1/28/medline SP - 1878 EP - 82 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin Infect Dis VL - 49 IS - 12 N2 - BACKGROUND: Antigen detection, which has proven useful in diagnosis of disseminated histoplasmosis, has not been studied in acute pulmonary histoplasmosis (APH). Because treatment is indicated in most patients with moderately severe or severe APH, antigen detection for rapid diagnosis could be helpful. METHODS: Histoplasma antigen detection was evaluated in 130 patients with APH. RESULTS: Antigenuria was detected in 64.6%, antigenemia in 68.6%, and antibody in 64.3%. If both urine and serum specimens were tested, antigen was detected in 82.8%, of which 45.8% had antigenemia only; and if both antigen and antibody were measured, results were positive in 93.3%, of which antigen only was positive in 35.7%. CONCLUSIONS: Testing for antigenemia, antigenuria, and antibodies using the complement fixation test offers a sensitive, noninvasive method for diagnosis of APH. SN - 1537-6591 UR - https://www.unboundmedicine.com/medline/citation/19911965/Diagnosis_of_acute_pulmonary_histoplasmosis_by_antigen_detection_ L2 - https://academic.oup.com/cid/article-lookup/doi/10.1086/648421 DB - PRIME DP - Unbound Medicine ER -