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The acute effect of smoking in healthy and asthmatic smokers.
Eur J Clin Invest. 2010 Feb; 40(2):103-9.EJ

Abstract

BACKGROUND

Acute exposure to cigarette smoke is related to airway and systemic inflammation and oxidative stress. Little is known about the acute effect of cigarette smoking in smoking asthmatics. The aim of this study was to evaluate the acute effect of smoking in airway and systemic inflammation and oxidative stress in normal smokers and patients with properly treated well-controlled persistent asthma.

MATERIALS AND METHODS

Ten normal smokers and 10 smokers with moderate persistent asthma controlled with LABA and ICS were recruited. Subjects refrained from smoking for at least 12 h prior to their inclusion. We compared the effects of smoking of two cigarettes on airway obstruction, airway inflammation and oxidative stress [by measuring fraction of exhaled nitric oxide (FeNO), plus pH and 8-isoprostane in exhaled breath condensate (EBC)] before and 30, 90 and 180 min after smoking. Furthermore, we evaluated systemic oxidative stress, C-reactive protein (CRP) and serum amyloid A (SAA) and urine leukotriene E(4) (LTE(4)) before and 180 min after smoking.

RESULTS

No differences were observed in EBC pH and 8-isoprostane, FeNO and systemic oxidative stress between the groups at baseline. In asthmatics, EBC pH decreased 30 min and EBC 8-isoprostane increased 90 min after smoking (P = 0.039 and P = 0.029 respectively), which was not evident in smoking controls. Serum oxidative stress increased only in asthmatic smokers at 180 min (P = 0.001). No differences were observed in SAA, CRP and urine LTE(4) levels before and after smoking.

CONCLUSION

Acute smoking has more deleterious effects in well-controlled properly treated asthmatic smokers compared with matched normal smokers.

Authors+Show Affiliations

University of Thessaly Medical School, Larissa, Greece.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19912318

Citation

Papaioannou, A I., et al. "The Acute Effect of Smoking in Healthy and Asthmatic Smokers." European Journal of Clinical Investigation, vol. 40, no. 2, 2010, pp. 103-9.
Papaioannou AI, Koutsokera A, Tanou K, et al. The acute effect of smoking in healthy and asthmatic smokers. Eur J Clin Invest. 2010;40(2):103-9.
Papaioannou, A. I., Koutsokera, A., Tanou, K., Kiropoulos, T. S., Tsilioni, I., Oikonomidi, S., Liadaki, K., Pournaras, S., Gourgoulianis, K. I., & Kostikas, K. (2010). The acute effect of smoking in healthy and asthmatic smokers. European Journal of Clinical Investigation, 40(2), 103-9. https://doi.org/10.1111/j.1365-2362.2009.02221.x
Papaioannou AI, et al. The Acute Effect of Smoking in Healthy and Asthmatic Smokers. Eur J Clin Invest. 2010;40(2):103-9. PubMed PMID: 19912318.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The acute effect of smoking in healthy and asthmatic smokers. AU - Papaioannou,A I, AU - Koutsokera,A, AU - Tanou,K, AU - Kiropoulos,T S, AU - Tsilioni,I, AU - Oikonomidi,S, AU - Liadaki,K, AU - Pournaras,S, AU - Gourgoulianis,K I, AU - Kostikas,K, Y1 - 2009/11/12/ PY - 2009/11/17/entrez PY - 2009/11/17/pubmed PY - 2010/5/12/medline SP - 103 EP - 9 JF - European journal of clinical investigation JO - Eur J Clin Invest VL - 40 IS - 2 N2 - BACKGROUND: Acute exposure to cigarette smoke is related to airway and systemic inflammation and oxidative stress. Little is known about the acute effect of cigarette smoking in smoking asthmatics. The aim of this study was to evaluate the acute effect of smoking in airway and systemic inflammation and oxidative stress in normal smokers and patients with properly treated well-controlled persistent asthma. MATERIALS AND METHODS: Ten normal smokers and 10 smokers with moderate persistent asthma controlled with LABA and ICS were recruited. Subjects refrained from smoking for at least 12 h prior to their inclusion. We compared the effects of smoking of two cigarettes on airway obstruction, airway inflammation and oxidative stress [by measuring fraction of exhaled nitric oxide (FeNO), plus pH and 8-isoprostane in exhaled breath condensate (EBC)] before and 30, 90 and 180 min after smoking. Furthermore, we evaluated systemic oxidative stress, C-reactive protein (CRP) and serum amyloid A (SAA) and urine leukotriene E(4) (LTE(4)) before and 180 min after smoking. RESULTS: No differences were observed in EBC pH and 8-isoprostane, FeNO and systemic oxidative stress between the groups at baseline. In asthmatics, EBC pH decreased 30 min and EBC 8-isoprostane increased 90 min after smoking (P = 0.039 and P = 0.029 respectively), which was not evident in smoking controls. Serum oxidative stress increased only in asthmatic smokers at 180 min (P = 0.001). No differences were observed in SAA, CRP and urine LTE(4) levels before and after smoking. CONCLUSION: Acute smoking has more deleterious effects in well-controlled properly treated asthmatic smokers compared with matched normal smokers. SN - 1365-2362 UR - https://www.unboundmedicine.com/medline/citation/19912318/The_acute_effect_of_smoking_in_healthy_and_asthmatic_smokers_ L2 - https://doi.org/10.1111/j.1365-2362.2009.02221.x DB - PRIME DP - Unbound Medicine ER -