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Evaluation of on-site oral fluid screening using Drugwipe-5(+), RapidSTAT and Drug Test 5000 for the detection of drugs of abuse in drivers.

Abstract

Driving under the influence of drugs is a major problem worldwide. At the moment, several countries have adopted a 'per se' legislation to address this problem. One of the key elements in the enforcement process is the possibility of rapid on-site screening tests to take immediate administrative measures. In this study, the reliability of three oral fluid screening devices (Mavand RapidSTAT, Securetec Drugwipe-5(+), and Dräger DrugTest 5000) was assessed by comparing their on-site results with confirmatory GC-MS plasma analysis. Our results demonstrate that for amphetamine screening, the oral fluid on-site devices on the market today are certainly sensitive enough. RapidSTAT, Drugwipe-5(+), and DrugTest 5000 demonstrated respectively a sensitivity of 93%, 100% and 92% for amphetamine/MDMA. For cocaine screening, sensitivities of 75%, 78% and 67% were obtained for the RapidSTAT, Drugwipe-5(+), and DrugTest 5000 devices, respectively. The studied devices were able to detect about 70% of all cannabis users in a roadside setting. However, a newer version of the DrugTest 5000 test cassette demonstrated a sensitivity of 93%, indicating an increased detection of Delta(9)-tetrahydrocannabinol using 'new generation' oral fluid screening tests with lowered cut-offs. Due to these promising results police officers and judicial experts are keen to use oral fluid screening devices. They believe that their ease of use and diminished amount of false positive results in comparison with urine screening will lead to more roadside tests and more appropriate juridical measures.

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  • Authors+Show Affiliations

    ,

    Federal Public Service Justice, National Institute of Criminalistics and Criminology, Vilvoordsesteenweg 100, Brussels, Belgium. Sarah.Wille@just.fgov.be

    , ,

    Source

    Forensic science international 198:1-3 2010 May 20 pg 2-6

    MeSH

    Amphetamines
    Automobile Driving
    Cocaine
    Dronabinol
    Forensic Toxicology
    Humans
    Morphine
    Narcotics
    Saliva
    Sensitivity and Specificity
    Substance Abuse Detection
    Substance-Related Disorders

    Pub Type(s)

    Comparative Study
    Evaluation Studies
    Journal Article

    Language

    eng

    PubMed ID

    19913376

    Citation

    Wille, Sarah M R., et al. "Evaluation of On-site Oral Fluid Screening Using Drugwipe-5(+), RapidSTAT and Drug Test 5000 for the Detection of Drugs of Abuse in Drivers." Forensic Science International, vol. 198, no. 1-3, 2010, pp. 2-6.
    Wille SM, Samyn N, Ramírez-Fernández Mdel M, et al. Evaluation of on-site oral fluid screening using Drugwipe-5(+), RapidSTAT and Drug Test 5000 for the detection of drugs of abuse in drivers. Forensic Sci Int. 2010;198(1-3):2-6.
    Wille, S. M., Samyn, N., Ramírez-Fernández, M. d. e. l. . M., & De Boeck, G. (2010). Evaluation of on-site oral fluid screening using Drugwipe-5(+), RapidSTAT and Drug Test 5000 for the detection of drugs of abuse in drivers. Forensic Science International, 198(1-3), pp. 2-6. doi:10.1016/j.forsciint.2009.10.012.
    Wille SM, et al. Evaluation of On-site Oral Fluid Screening Using Drugwipe-5(+), RapidSTAT and Drug Test 5000 for the Detection of Drugs of Abuse in Drivers. Forensic Sci Int. 2010 May 20;198(1-3):2-6. PubMed PMID: 19913376.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Evaluation of on-site oral fluid screening using Drugwipe-5(+), RapidSTAT and Drug Test 5000 for the detection of drugs of abuse in drivers. AU - Wille,Sarah M R, AU - Samyn,Nele, AU - Ramírez-Fernández,Maria del Mar, AU - De Boeck,Gert, Y1 - 2009/11/12/ PY - 2009/08/20/received PY - 2009/10/01/revised PY - 2009/10/09/accepted PY - 2009/11/17/entrez PY - 2009/11/17/pubmed PY - 2010/8/19/medline SP - 2 EP - 6 JF - Forensic science international JO - Forensic Sci. Int. VL - 198 IS - 1-3 N2 - Driving under the influence of drugs is a major problem worldwide. At the moment, several countries have adopted a 'per se' legislation to address this problem. One of the key elements in the enforcement process is the possibility of rapid on-site screening tests to take immediate administrative measures. In this study, the reliability of three oral fluid screening devices (Mavand RapidSTAT, Securetec Drugwipe-5(+), and Dräger DrugTest 5000) was assessed by comparing their on-site results with confirmatory GC-MS plasma analysis. Our results demonstrate that for amphetamine screening, the oral fluid on-site devices on the market today are certainly sensitive enough. RapidSTAT, Drugwipe-5(+), and DrugTest 5000 demonstrated respectively a sensitivity of 93%, 100% and 92% for amphetamine/MDMA. For cocaine screening, sensitivities of 75%, 78% and 67% were obtained for the RapidSTAT, Drugwipe-5(+), and DrugTest 5000 devices, respectively. The studied devices were able to detect about 70% of all cannabis users in a roadside setting. However, a newer version of the DrugTest 5000 test cassette demonstrated a sensitivity of 93%, indicating an increased detection of Delta(9)-tetrahydrocannabinol using 'new generation' oral fluid screening tests with lowered cut-offs. Due to these promising results police officers and judicial experts are keen to use oral fluid screening devices. They believe that their ease of use and diminished amount of false positive results in comparison with urine screening will lead to more roadside tests and more appropriate juridical measures. SN - 1872-6283 UR - https://www.unboundmedicine.com/medline/citation/19913376/full_citation/Evaluation_of_on_site_oral_fluid_screening_using_Drugwipe_5_+_R___RapidSTAT__R___and_Drug_Test_5000__R___for_the_detection_of_drugs_of_abuse_in_drivers_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0379-0738(09)00423-X DB - PRIME DP - Unbound Medicine ER -