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Serum complement C3: a determinant of cardiometabolic risk, additive to the metabolic syndrome, in middle-aged population.
Metabolism. 2010 May; 59(5):628-34.M

Abstract

We studied whether serum complement C3 (C3) is an independent determinant of incident cardiometabolic risk (coronary heart disease [CHD], metabolic syndrome [MetS], and type 2 diabetes mellitus). A cohort of 1220 adults of a general population (age, 53 +/- 10.5 years) was evaluated prospectively at 3.3 years follow-up using Cox proportional hazard regressions. Cardiometabolic risk factors were measured. Metabolic syndrome was identified by Adult Treatment Panel III criteria modified for male abdominal obesity. The C3 levels were associated significantly and linearly with serum triglycerides, waist circumference, and C-reactive protein (CRP), and inversely with current smoking but not with the marker of insulin resistance. In regression models for incident MetS, increasing C3 quartiles strongly predicted MetS in women and in both sexes combined after adjusting for all 5 MetS components and other confounders. Circulating C3 significantly predicted in each sex incident CHD independent of age, smoking status, and presence of MetS. Even after entering CRP, C3 predicted CHD with a relative risk of 1.35 (95% confidence interval, 1.09-1.67) for 1-SD increment of C3 in the total sample. Complement C3 tended to contribute, additively to MetS, to the association with diabetes with a relative risk of 1.36 in women alone, not in men. In conclusion, elevated serum complement C3 is part of the MetS cluster and confers CHD risk, additively to MetS components and CRP, in a population in which MetS prevails. Levels contribute, additively to MetS, to the diabetes risk in women alone.

Authors+Show Affiliations

Turkish Society of Cardiology, Istanbul, Turkey. alt_onat@yahoo.com.trNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19913840

Citation

Onat, Altan, et al. "Serum Complement C3: a Determinant of Cardiometabolic Risk, Additive to the Metabolic Syndrome, in Middle-aged Population." Metabolism: Clinical and Experimental, vol. 59, no. 5, 2010, pp. 628-34.
Onat A, Hergenç G, Can G, et al. Serum complement C3: a determinant of cardiometabolic risk, additive to the metabolic syndrome, in middle-aged population. Metab Clin Exp. 2010;59(5):628-34.
Onat, A., Hergenç, G., Can, G., Kaya, Z., & Yüksel, H. (2010). Serum complement C3: a determinant of cardiometabolic risk, additive to the metabolic syndrome, in middle-aged population. Metabolism: Clinical and Experimental, 59(5), 628-34. https://doi.org/10.1016/j.metabol.2009.09.006
Onat A, et al. Serum Complement C3: a Determinant of Cardiometabolic Risk, Additive to the Metabolic Syndrome, in Middle-aged Population. Metab Clin Exp. 2010;59(5):628-34. PubMed PMID: 19913840.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum complement C3: a determinant of cardiometabolic risk, additive to the metabolic syndrome, in middle-aged population. AU - Onat,Altan, AU - Hergenç,Gülay, AU - Can,Günay, AU - Kaya,Zekeriya, AU - Yüksel,Hüsniye, Y1 - 2009/11/14/ PY - 2009/07/16/received PY - 2009/08/27/revised PY - 2009/09/04/accepted PY - 2009/11/17/entrez PY - 2009/11/17/pubmed PY - 2010/5/4/medline SP - 628 EP - 34 JF - Metabolism: clinical and experimental JO - Metab. Clin. Exp. VL - 59 IS - 5 N2 - We studied whether serum complement C3 (C3) is an independent determinant of incident cardiometabolic risk (coronary heart disease [CHD], metabolic syndrome [MetS], and type 2 diabetes mellitus). A cohort of 1220 adults of a general population (age, 53 +/- 10.5 years) was evaluated prospectively at 3.3 years follow-up using Cox proportional hazard regressions. Cardiometabolic risk factors were measured. Metabolic syndrome was identified by Adult Treatment Panel III criteria modified for male abdominal obesity. The C3 levels were associated significantly and linearly with serum triglycerides, waist circumference, and C-reactive protein (CRP), and inversely with current smoking but not with the marker of insulin resistance. In regression models for incident MetS, increasing C3 quartiles strongly predicted MetS in women and in both sexes combined after adjusting for all 5 MetS components and other confounders. Circulating C3 significantly predicted in each sex incident CHD independent of age, smoking status, and presence of MetS. Even after entering CRP, C3 predicted CHD with a relative risk of 1.35 (95% confidence interval, 1.09-1.67) for 1-SD increment of C3 in the total sample. Complement C3 tended to contribute, additively to MetS, to the association with diabetes with a relative risk of 1.36 in women alone, not in men. In conclusion, elevated serum complement C3 is part of the MetS cluster and confers CHD risk, additively to MetS components and CRP, in a population in which MetS prevails. Levels contribute, additively to MetS, to the diabetes risk in women alone. SN - 1532-8600 UR - https://www.unboundmedicine.com/medline/citation/19913840/Serum_complement_C3:_a_determinant_of_cardiometabolic_risk_additive_to_the_metabolic_syndrome_in_middle_aged_population_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(09)00380-1 DB - PRIME DP - Unbound Medicine ER -