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The polyhydroxylated fullerene derivative C60(OH)24 protects mice from ionizing-radiation-induced immune and mitochondrial dysfunction.
Toxicol Appl Pharmacol. 2010 Feb 15; 243(1):27-34.TA

Abstract

Although the protective effect of the polyhydroxylated fullerene derivative C(60)(OH)(n) against ionizing radiation is an area of much interest, the mechanisms relating to how polyhydroxylated fullerene derivatives improve mitochondrial dysfunction remain unknown. In order to find new and effective radioprotective agents, we synthesized a new polyhydroxylated fullerene molecule with 24 hydroxyl groups of known positions on C(60) and studied its protective effects in mice subjected to irradiation. Mice were pretreated with C(60)(OH)(24) for 2 weeks (daily, 40 mg/kg i. p.), then subjected to a lethal dose of whole body gamma-irradiation (from a (60)Co source). Survival was observed for 30 days after irradiation. Immune and mitochondrial dysfunction and oxidative damage were analyzed in mice with the same C(60)(OH)(24) pretreatment and irradiation except that the animals were euthanized at day 5 after the irradiation. It was found that 2-week C(60)(OH)(24) pretreatment effectively reduced whole body irradiation-induced mortality without apparent toxicity. C(60)(OH)(24) pretreatment also showed significant protective effects against ionizing-radiation-induced decreases in immune and mitochondrial function and antioxidant defense in the liver and spleen. These results suggest that the polyhydroxylated fullerene derivative C(60)(OH)(24) protects against ionizing-radiation-induced mortality, possibly by enhancing immune function, decreasing oxidative damage and improving mitochondrial function.

Authors+Show Affiliations

Laboratory of physical Biology, Shanghai Institure of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19914272

Citation

Cai, Xiaoqing, et al. "The Polyhydroxylated Fullerene Derivative C60(OH)24 Protects Mice From Ionizing-radiation-induced Immune and Mitochondrial Dysfunction." Toxicology and Applied Pharmacology, vol. 243, no. 1, 2010, pp. 27-34.
Cai X, Hao J, Zhang X, et al. The polyhydroxylated fullerene derivative C60(OH)24 protects mice from ionizing-radiation-induced immune and mitochondrial dysfunction. Toxicol Appl Pharmacol. 2010;243(1):27-34.
Cai, X., Hao, J., Zhang, X., Yu, B., Ren, J., Luo, C., Li, Q., Huang, Q., Shi, X., Li, W., & Liu, J. (2010). The polyhydroxylated fullerene derivative C60(OH)24 protects mice from ionizing-radiation-induced immune and mitochondrial dysfunction. Toxicology and Applied Pharmacology, 243(1), 27-34. https://doi.org/10.1016/j.taap.2009.11.009
Cai X, et al. The Polyhydroxylated Fullerene Derivative C60(OH)24 Protects Mice From Ionizing-radiation-induced Immune and Mitochondrial Dysfunction. Toxicol Appl Pharmacol. 2010 Feb 15;243(1):27-34. PubMed PMID: 19914272.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The polyhydroxylated fullerene derivative C60(OH)24 protects mice from ionizing-radiation-induced immune and mitochondrial dysfunction. AU - Cai,Xiaoqing, AU - Hao,Jiejie, AU - Zhang,Xiaoyong, AU - Yu,Bozhang, AU - Ren,Jinming, AU - Luo,Cheng, AU - Li,Qingnuan, AU - Huang,Qing, AU - Shi,Xianglin, AU - Li,Wenxin, AU - Liu,Jiankang, Y1 - 2009/11/13/ PY - 2009/03/13/received PY - 2009/11/03/revised PY - 2009/11/06/accepted PY - 2009/11/17/entrez PY - 2009/11/17/pubmed PY - 2010/3/11/medline SP - 27 EP - 34 JF - Toxicology and applied pharmacology JO - Toxicol Appl Pharmacol VL - 243 IS - 1 N2 - Although the protective effect of the polyhydroxylated fullerene derivative C(60)(OH)(n) against ionizing radiation is an area of much interest, the mechanisms relating to how polyhydroxylated fullerene derivatives improve mitochondrial dysfunction remain unknown. In order to find new and effective radioprotective agents, we synthesized a new polyhydroxylated fullerene molecule with 24 hydroxyl groups of known positions on C(60) and studied its protective effects in mice subjected to irradiation. Mice were pretreated with C(60)(OH)(24) for 2 weeks (daily, 40 mg/kg i. p.), then subjected to a lethal dose of whole body gamma-irradiation (from a (60)Co source). Survival was observed for 30 days after irradiation. Immune and mitochondrial dysfunction and oxidative damage were analyzed in mice with the same C(60)(OH)(24) pretreatment and irradiation except that the animals were euthanized at day 5 after the irradiation. It was found that 2-week C(60)(OH)(24) pretreatment effectively reduced whole body irradiation-induced mortality without apparent toxicity. C(60)(OH)(24) pretreatment also showed significant protective effects against ionizing-radiation-induced decreases in immune and mitochondrial function and antioxidant defense in the liver and spleen. These results suggest that the polyhydroxylated fullerene derivative C(60)(OH)(24) protects against ionizing-radiation-induced mortality, possibly by enhancing immune function, decreasing oxidative damage and improving mitochondrial function. SN - 1096-0333 UR - https://www.unboundmedicine.com/medline/citation/19914272/The_polyhydroxylated_fullerene_derivative_C60_OH_24_protects_mice_from_ionizing_radiation_induced_immune_and_mitochondrial_dysfunction_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0041-008X(09)00475-X DB - PRIME DP - Unbound Medicine ER -