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Changes of some oxidative stress markers in the serum of patients with mild cognitive impairment and Alzheimer's disease.
Neurosci Lett 2010; 469(1):6-10NL

Abstract

Mild cognitive impairment (MCI) is a nosological entity proposed as an intermediate state between normal aging and dementia. MCI seems to represent an early stage of Alzheimer's disease (AD) and there is a great interest in the relationship between MCI and the progression to AD. Some studies have demonstrated an accumulation of products of free radical damage in the central nervous system and in the peripheral tissues of subjects with AD or mild cognitive impairment. The aim of the present work was to evaluate the serum levels of some enzymatic antioxidant defences like superoxide dismutase (SOD) and glutathione peroxidase (GPX), as well as lipid peroxidation markers like MDA (malondialdehyde), in MCI and AD patients, compared with age-matched healthy controls. The subjects of this study (45 patients) consisted of 15 individuals with mild cognitive impairment (MCI), 15 with Alzheimer's disease (AD) and 15 healthy age-matched controls. Biochemical analyses showed a similar decrease of the main enzymatic antioxidant defences (SOD and GPX) and increased production of lipid peroxidation marker (MDA) in the serum of the MCI and AD patients, compared to age-matched control group. This study clearly demonstrates that oxidative stress damage occurs in patients with MCI and AD. Moreover, some enzymatic markers of oxidative stress are similar in MCI and AD patients, suggesting that oxidative damage could be one important aspect for the onset of AD.

Authors+Show Affiliations

Department of Biology, Gr. T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19914330

Citation

Padurariu, Manuela, et al. "Changes of some Oxidative Stress Markers in the Serum of Patients With Mild Cognitive Impairment and Alzheimer's Disease." Neuroscience Letters, vol. 469, no. 1, 2010, pp. 6-10.
Padurariu M, Ciobica A, Hritcu L, et al. Changes of some oxidative stress markers in the serum of patients with mild cognitive impairment and Alzheimer's disease. Neurosci Lett. 2010;469(1):6-10.
Padurariu, M., Ciobica, A., Hritcu, L., Stoica, B., Bild, W., & Stefanescu, C. (2010). Changes of some oxidative stress markers in the serum of patients with mild cognitive impairment and Alzheimer's disease. Neuroscience Letters, 469(1), pp. 6-10. doi:10.1016/j.neulet.2009.11.033.
Padurariu M, et al. Changes of some Oxidative Stress Markers in the Serum of Patients With Mild Cognitive Impairment and Alzheimer's Disease. Neurosci Lett. 2010 Jan 18;469(1):6-10. PubMed PMID: 19914330.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changes of some oxidative stress markers in the serum of patients with mild cognitive impairment and Alzheimer's disease. AU - Padurariu,Manuela, AU - Ciobica,Alin, AU - Hritcu,Lucian, AU - Stoica,Bogdan, AU - Bild,Walther, AU - Stefanescu,Cristinel, Y1 - 2009/11/13/ PY - 2009/10/11/received PY - 2009/11/04/revised PY - 2009/11/09/accepted PY - 2009/11/17/entrez PY - 2009/11/17/pubmed PY - 2010/3/10/medline SP - 6 EP - 10 JF - Neuroscience letters JO - Neurosci. Lett. VL - 469 IS - 1 N2 - Mild cognitive impairment (MCI) is a nosological entity proposed as an intermediate state between normal aging and dementia. MCI seems to represent an early stage of Alzheimer's disease (AD) and there is a great interest in the relationship between MCI and the progression to AD. Some studies have demonstrated an accumulation of products of free radical damage in the central nervous system and in the peripheral tissues of subjects with AD or mild cognitive impairment. The aim of the present work was to evaluate the serum levels of some enzymatic antioxidant defences like superoxide dismutase (SOD) and glutathione peroxidase (GPX), as well as lipid peroxidation markers like MDA (malondialdehyde), in MCI and AD patients, compared with age-matched healthy controls. The subjects of this study (45 patients) consisted of 15 individuals with mild cognitive impairment (MCI), 15 with Alzheimer's disease (AD) and 15 healthy age-matched controls. Biochemical analyses showed a similar decrease of the main enzymatic antioxidant defences (SOD and GPX) and increased production of lipid peroxidation marker (MDA) in the serum of the MCI and AD patients, compared to age-matched control group. This study clearly demonstrates that oxidative stress damage occurs in patients with MCI and AD. Moreover, some enzymatic markers of oxidative stress are similar in MCI and AD patients, suggesting that oxidative damage could be one important aspect for the onset of AD. SN - 1872-7972 UR - https://www.unboundmedicine.com/medline/citation/19914330/Changes_of_some_oxidative_stress_markers_in_the_serum_of_patients_with_mild_cognitive_impairment_and_Alzheimer's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(09)01499-2 DB - PRIME DP - Unbound Medicine ER -