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Variables influencing antidepressant medication adherence for treating outpatients with depressive disorders.
J Affect Disord. 2010 Jun; 123(1-3):216-21.JA

Abstract

OBJECTIVE

Medication adherence is associated with the treatment outcomes. The reported consequences of non-adherence for patients with depressive disorders include chronification, poor psychosocial outcomes and increased suicide rates. The aim of this study is to determine whether insight is directly associated with the medication-taking adherence of patients with depressive disorders. In addition, we compared the various kinds of adherence measures for the depressive patients.

METHOD

Consecutively 76 patients with depressive disorders were recruited from the outpatient clinic of our center. All patients were on mono-antidepressant therapy during at least 4-weeks' evaluation period, and evaluated with 17 item Hamilton Rating Scale for Depression (HRSD), Multidimensional Scale of Perceived Social Support (MSPSS) and Mood Disorders Insight Scale (MDIS). Medication adherence was assessed by using medication event monitoring system (MEMS), clinician rating scale of antidepressant adherence, pill count and patient's self-report. Agreement among the three continuous adherence measures was evaluated. The relationship between the adherence variables and the other clinical scale scores was assessed by using partial correlation correcting for age.

RESULTS

The patients perceived poor social support from other people in relation to increasing severity of depression. The adherence rates for the MEMS, the pill count, the clinician rating scale of compliance and self-report were 51.9%, 71.4%, 79.2% and 75.3%, respectively. The HRSD scale score negatively correlated with the MDIS scores. No correlation was found between the adherence variables and the clinical scale scores (MDIS, HRSD and MSPSS).

CONCLUSION

Patients with more severe depression tend to have greater insight. However, the increased insight of depressive patients was not associated with an increase in treatment adherence.

Authors+Show Affiliations

Department of Neuropsychiatry, Korea University College of Medicine, Seoul, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19914719

Citation

Lee, Moon-Soo, et al. "Variables Influencing Antidepressant Medication Adherence for Treating Outpatients With Depressive Disorders." Journal of Affective Disorders, vol. 123, no. 1-3, 2010, pp. 216-21.
Lee MS, Lee HY, Kang SG, et al. Variables influencing antidepressant medication adherence for treating outpatients with depressive disorders. J Affect Disord. 2010;123(1-3):216-21.
Lee, M. S., Lee, H. Y., Kang, S. G., Yang, J., Ahn, H., Rhee, M., Ko, Y. H., Joe, S. H., Jung, I. K., & Kim, S. H. (2010). Variables influencing antidepressant medication adherence for treating outpatients with depressive disorders. Journal of Affective Disorders, 123(1-3), 216-21. https://doi.org/10.1016/j.jad.2009.10.002
Lee MS, et al. Variables Influencing Antidepressant Medication Adherence for Treating Outpatients With Depressive Disorders. J Affect Disord. 2010;123(1-3):216-21. PubMed PMID: 19914719.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Variables influencing antidepressant medication adherence for treating outpatients with depressive disorders. AU - Lee,Moon-Soo, AU - Lee,Hwa-Young, AU - Kang,Seung-Gul, AU - Yang,Jaewon, AU - Ahn,Hyonggin, AU - Rhee,Minkyu, AU - Ko,Young-Hoon, AU - Joe,Sook-Haeng, AU - Jung,In-Kwa, AU - Kim,Seung-Hyun, Y1 - 2009/11/14/ PY - 2009/01/30/received PY - 2009/10/08/revised PY - 2009/10/08/accepted PY - 2009/11/17/entrez PY - 2009/11/17/pubmed PY - 2010/7/27/medline SP - 216 EP - 21 JF - Journal of affective disorders JO - J Affect Disord VL - 123 IS - 1-3 N2 - OBJECTIVE: Medication adherence is associated with the treatment outcomes. The reported consequences of non-adherence for patients with depressive disorders include chronification, poor psychosocial outcomes and increased suicide rates. The aim of this study is to determine whether insight is directly associated with the medication-taking adherence of patients with depressive disorders. In addition, we compared the various kinds of adherence measures for the depressive patients. METHOD: Consecutively 76 patients with depressive disorders were recruited from the outpatient clinic of our center. All patients were on mono-antidepressant therapy during at least 4-weeks' evaluation period, and evaluated with 17 item Hamilton Rating Scale for Depression (HRSD), Multidimensional Scale of Perceived Social Support (MSPSS) and Mood Disorders Insight Scale (MDIS). Medication adherence was assessed by using medication event monitoring system (MEMS), clinician rating scale of antidepressant adherence, pill count and patient's self-report. Agreement among the three continuous adherence measures was evaluated. The relationship between the adherence variables and the other clinical scale scores was assessed by using partial correlation correcting for age. RESULTS: The patients perceived poor social support from other people in relation to increasing severity of depression. The adherence rates for the MEMS, the pill count, the clinician rating scale of compliance and self-report were 51.9%, 71.4%, 79.2% and 75.3%, respectively. The HRSD scale score negatively correlated with the MDIS scores. No correlation was found between the adherence variables and the clinical scale scores (MDIS, HRSD and MSPSS). CONCLUSION: Patients with more severe depression tend to have greater insight. However, the increased insight of depressive patients was not associated with an increase in treatment adherence. SN - 1573-2517 UR - https://www.unboundmedicine.com/medline/citation/19914719/Variables_influencing_antidepressant_medication_adherence_for_treating_outpatients_with_depressive_disorders_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-0327(09)00462-5 DB - PRIME DP - Unbound Medicine ER -