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Effectiveness of combined haloperidol and dexamethasone versus dexamethasone only for postoperative nausea and vomiting in high-risk day surgery patients: a randomized blinded trial.
Eur J Anaesthesiol. 2010 Feb; 27(2):192-5.EJ

Abstract

BACKGROUND AND OBJECTIVE

To examine whether prophylactic use of haloperidol in addition to dexamethasone decreased the incidence of postoperative nausea and vomiting in high-risk patients undergoing ambulatory surgery.

METHODS

One hundred and sixty nonsmoking women aged between 18 and 50 years receiving a standardized anaesthesia, which included dexamethasone 8 mg at the beginning of cosmetic or ENT surgery, were enrolled. They were randomized to receive either 1.5 mg of haloperidol (dexamethasone-haloperidol group) or placebo (dexamethasone-placebo group) 30 min before the end of surgery. The incidence of postoperative nausea and vomiting was assessed by a blinded investigator at 30 min, 2, 6, and 24 h in the postoperative period. Analgesic requirements, eye opening time, and sedation were also assessed.

RESULTS

We found no differences in nausea or vomiting at 30 min and 2 h postoperatively; we found no difference in the incidence of nausea between dexamethasone-haloperidol and dexamethasone-placebo groups at 6 h [relative risk (RR) 0.82, 95% confidence interval (CI) 0.56-1.25] and 24 h (RR 0.79, 95% CI 0.56-1.1), but the cumulative incidence of vomiting in the dexamethasone-haloperidol group was significantly lower at 6 h (RR 0.57, 95% CI 0.39-1.05) and 24 h (RR 0.54, 95% CI 0.31-0.86). We found no differences in eye opening time and Ramsay score higher than 2 at 30 min and 2 h after surgery.

CONCLUSION

To combine 1.5 mg of haloperidol and 8 mg of dexamethasone reduces the cumulative incidence of postoperative vomiting at 6 and 24 h postoperatively in day patients at high risk of postoperative nausea and vomiting.

Authors+Show Affiliations

Department of Anesthesia, University of Antioquia, IPS Universitaria, Medellín, Colombia. luisdr74@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19915480

Citation

Chaparro, Luis E., et al. "Effectiveness of Combined Haloperidol and Dexamethasone Versus Dexamethasone Only for Postoperative Nausea and Vomiting in High-risk Day Surgery Patients: a Randomized Blinded Trial." European Journal of Anaesthesiology, vol. 27, no. 2, 2010, pp. 192-5.
Chaparro LE, Gallo T, Gonzalez NJ, et al. Effectiveness of combined haloperidol and dexamethasone versus dexamethasone only for postoperative nausea and vomiting in high-risk day surgery patients: a randomized blinded trial. Eur J Anaesthesiol. 2010;27(2):192-5.
Chaparro, L. E., Gallo, T., Gonzalez, N. J., Rivera, M. F., & Peng, P. W. (2010). Effectiveness of combined haloperidol and dexamethasone versus dexamethasone only for postoperative nausea and vomiting in high-risk day surgery patients: a randomized blinded trial. European Journal of Anaesthesiology, 27(2), 192-5. https://doi.org/10.1097/EJA.0b013e32832fce15
Chaparro LE, et al. Effectiveness of Combined Haloperidol and Dexamethasone Versus Dexamethasone Only for Postoperative Nausea and Vomiting in High-risk Day Surgery Patients: a Randomized Blinded Trial. Eur J Anaesthesiol. 2010;27(2):192-5. PubMed PMID: 19915480.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effectiveness of combined haloperidol and dexamethasone versus dexamethasone only for postoperative nausea and vomiting in high-risk day surgery patients: a randomized blinded trial. AU - Chaparro,Luis E, AU - Gallo,Tatiana, AU - Gonzalez,Nelson J, AU - Rivera,Maria F, AU - Peng,Philip W, PY - 2009/11/17/entrez PY - 2009/11/17/pubmed PY - 2010/3/31/medline SP - 192 EP - 5 JF - European journal of anaesthesiology JO - Eur J Anaesthesiol VL - 27 IS - 2 N2 - BACKGROUND AND OBJECTIVE: To examine whether prophylactic use of haloperidol in addition to dexamethasone decreased the incidence of postoperative nausea and vomiting in high-risk patients undergoing ambulatory surgery. METHODS: One hundred and sixty nonsmoking women aged between 18 and 50 years receiving a standardized anaesthesia, which included dexamethasone 8 mg at the beginning of cosmetic or ENT surgery, were enrolled. They were randomized to receive either 1.5 mg of haloperidol (dexamethasone-haloperidol group) or placebo (dexamethasone-placebo group) 30 min before the end of surgery. The incidence of postoperative nausea and vomiting was assessed by a blinded investigator at 30 min, 2, 6, and 24 h in the postoperative period. Analgesic requirements, eye opening time, and sedation were also assessed. RESULTS: We found no differences in nausea or vomiting at 30 min and 2 h postoperatively; we found no difference in the incidence of nausea between dexamethasone-haloperidol and dexamethasone-placebo groups at 6 h [relative risk (RR) 0.82, 95% confidence interval (CI) 0.56-1.25] and 24 h (RR 0.79, 95% CI 0.56-1.1), but the cumulative incidence of vomiting in the dexamethasone-haloperidol group was significantly lower at 6 h (RR 0.57, 95% CI 0.39-1.05) and 24 h (RR 0.54, 95% CI 0.31-0.86). We found no differences in eye opening time and Ramsay score higher than 2 at 30 min and 2 h after surgery. CONCLUSION: To combine 1.5 mg of haloperidol and 8 mg of dexamethasone reduces the cumulative incidence of postoperative vomiting at 6 and 24 h postoperatively in day patients at high risk of postoperative nausea and vomiting. SN - 1365-2346 UR - https://www.unboundmedicine.com/medline/citation/19915480/Effectiveness_of_combined_haloperidol_and_dexamethasone_versus_dexamethasone_only_for_postoperative_nausea_and_vomiting_in_high_risk_day_surgery_patients:_a_randomized_blinded_trial_ L2 - https://doi.org/10.1097/EJA.0b013e32832fce15 DB - PRIME DP - Unbound Medicine ER -