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A QCAR model for predicting antioxidant activity of wild mushrooms.
SAR QSAR Environ Res. 2009 Jul; 20(5-6):579-90.SQ

Abstract

Wild mushrooms have been described as sources of natural antioxidants, particularly phenolic compounds. However, many other compounds present in wild mushrooms can also act as antioxidants (reducers), so whole extracts from a wide range of species need to be examined. To gain further knowledge in this area, the relationship between the antioxidant potential (scavenging effect and reducing power) and chemical composition of twenty three samples from seventeen Portuguese wild mushroom species was investigated. A wide range of analytical parameters reported by our research group (including ash, carbohydrates, proteins, fat, monounsaturated fatty acids, polyunsaturated fatty acids, saturated fatty acids, phenolics, flavonoids, ascorbic acid and beta-carotene) were studied and the data were analysed by partial least squares (PLS) regression analysis to allow correlation of all the parameters. Antioxidant activity correlated well with phenolic and flavonoid contents. A QCAR (Quantitative Composition-Activity Relationships) model was constructed, using the PLS method, and its robustness and predictability were verified by internal and external cross-validation methods. Finally, this model proved to be a useful tool in the prediction of mushrooms' reducing power.

Authors+Show Affiliations

CIMO/Escola Superior Agrária, Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5301-855 Bragança, Portugal.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Validation Study

Language

eng

PubMed ID

19916116

Citation

Froufe, H J C., et al. "A QCAR Model for Predicting Antioxidant Activity of Wild Mushrooms." SAR and QSAR in Environmental Research, vol. 20, no. 5-6, 2009, pp. 579-90.
Froufe HJ, Abreu RM, Ferreira IC. A QCAR model for predicting antioxidant activity of wild mushrooms. SAR QSAR Environ Res. 2009;20(5-6):579-90.
Froufe, H. J., Abreu, R. M., & Ferreira, I. C. (2009). A QCAR model for predicting antioxidant activity of wild mushrooms. SAR and QSAR in Environmental Research, 20(5-6), 579-90. https://doi.org/10.1080/10629360903408423
Froufe HJ, Abreu RM, Ferreira IC. A QCAR Model for Predicting Antioxidant Activity of Wild Mushrooms. SAR QSAR Environ Res. 2009;20(5-6):579-90. PubMed PMID: 19916116.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A QCAR model for predicting antioxidant activity of wild mushrooms. AU - Froufe,H J C, AU - Abreu,R M V, AU - Ferreira,I C F R, PY - 2009/11/17/entrez PY - 2009/11/17/pubmed PY - 2010/1/13/medline SP - 579 EP - 90 JF - SAR and QSAR in environmental research JO - SAR QSAR Environ Res VL - 20 IS - 5-6 N2 - Wild mushrooms have been described as sources of natural antioxidants, particularly phenolic compounds. However, many other compounds present in wild mushrooms can also act as antioxidants (reducers), so whole extracts from a wide range of species need to be examined. To gain further knowledge in this area, the relationship between the antioxidant potential (scavenging effect and reducing power) and chemical composition of twenty three samples from seventeen Portuguese wild mushroom species was investigated. A wide range of analytical parameters reported by our research group (including ash, carbohydrates, proteins, fat, monounsaturated fatty acids, polyunsaturated fatty acids, saturated fatty acids, phenolics, flavonoids, ascorbic acid and beta-carotene) were studied and the data were analysed by partial least squares (PLS) regression analysis to allow correlation of all the parameters. Antioxidant activity correlated well with phenolic and flavonoid contents. A QCAR (Quantitative Composition-Activity Relationships) model was constructed, using the PLS method, and its robustness and predictability were verified by internal and external cross-validation methods. Finally, this model proved to be a useful tool in the prediction of mushrooms' reducing power. SN - 1029-046X UR - https://www.unboundmedicine.com/medline/citation/19916116/A_QCAR_model_for_predicting_antioxidant_activity_of_wild_mushrooms_ L2 - https://www.tandfonline.com/doi/full/10.1080/10629360903408423 DB - PRIME DP - Unbound Medicine ER -