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Argentinean propolis from Zuccagnia punctata Cav. (Caesalpinieae) exudates: phytochemical characterization and antifungal activity.
J Agric Food Chem. 2010 Jan 13; 58(1):194-201.JA

Abstract

This paper reports the in vitro antifungal activity of propolis extracts from the province of Tucuman (Argentina) as well as the identification of their main antifungal compounds and botanical origin. The antifungal activity was determined by the microdilution technique, using reference microorganisms and clinical isolates. All dermatophytes and yeasts tested were strongly inhibited by different propolis extracts (MICs between 16 and 125 microg mL(-1)). The most susceptible species were Microsporum gypseum, Trichophyton mentagrophytes, and Trichophyton rubrum. The main bioactive compounds were 2',4'-dihydroxy-3'-methoxychalcone 2 and 2',4'-dihydroxychalcone 3. Both displayed strong activity against clinical isolates of T. rubrum and T. mentagrophytes (MICs and MFCs between 1.9 and 2.9 microg mL(-1)). Additionally, galangin 5, pinocembrin 6, and 7-hydroxy-8-methoxyflavanone 9 were isolated from propolis samples and Zuccagnia punctata exudates, showing moderate antifungal activity. This is the first study matching the chemical profile of Z. punctata Cav. exudates with their corresponding propolis, giving strong evidence on the botanical origin of the studied propolis.

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Authors+Show Affiliations

Agüero MB
Instituto de Biotecnología, Universidad Nacional de San Juan, Avenida Libertador General San Martin 1109 (O), 5400 San Juan, Argentina.
Gonzalez M
No affiliation info available
Lima B
No affiliation info available
Svetaz L
No affiliation info available
Sánchez M
No affiliation info available
Zacchino S
No affiliation info available
Feresin GE
No affiliation info available
Schmeda-Hirschmann G
No affiliation info available
Palermo J
No affiliation info available
Wunderlin D
No affiliation info available
Tapia A
No affiliation info available

MeSH

Antifungal AgentsArgentinaArthrodermataceaeFabaceaePlant ExtractsPropolisYeasts

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19916546

Citation

Agüero, María Belén, et al. "Argentinean Propolis From Zuccagnia Punctata Cav. (Caesalpinieae) Exudates: Phytochemical Characterization and Antifungal Activity." Journal of Agricultural and Food Chemistry, vol. 58, no. 1, 2010, pp. 194-201.
Agüero MB, Gonzalez M, Lima B, et al. Argentinean propolis from Zuccagnia punctata Cav. (Caesalpinieae) exudates: phytochemical characterization and antifungal activity. J Agric Food Chem. 2010;58(1):194-201.
Agüero, M. B., Gonzalez, M., Lima, B., Svetaz, L., Sánchez, M., Zacchino, S., Feresin, G. E., Schmeda-Hirschmann, G., Palermo, J., Wunderlin, D., & Tapia, A. (2010). Argentinean propolis from Zuccagnia punctata Cav. (Caesalpinieae) exudates: phytochemical characterization and antifungal activity. Journal of Agricultural and Food Chemistry, 58(1), 194-201. https://doi.org/10.1021/jf902991t
Agüero MB, et al. Argentinean Propolis From Zuccagnia Punctata Cav. (Caesalpinieae) Exudates: Phytochemical Characterization and Antifungal Activity. J Agric Food Chem. 2010 Jan 13;58(1):194-201. PubMed PMID: 19916546.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Argentinean propolis from Zuccagnia punctata Cav. (Caesalpinieae) exudates: phytochemical characterization and antifungal activity. AU - Agüero,María Belén, AU - Gonzalez,Mariela, AU - Lima,Beatriz, AU - Svetaz,Laura, AU - Sánchez,Marianela, AU - Zacchino,Susana, AU - Feresin,Gabriela Egly, AU - Schmeda-Hirschmann,Guillermo, AU - Palermo,Jorge, AU - Wunderlin,Daniel, AU - Tapia,Alejandro, PY - 2009/11/18/entrez PY - 2009/11/18/pubmed PY - 2010/3/23/medline SP - 194 EP - 201 JF - Journal of agricultural and food chemistry JO - J Agric Food Chem VL - 58 IS - 1 N2 - This paper reports the in vitro antifungal activity of propolis extracts from the province of Tucuman (Argentina) as well as the identification of their main antifungal compounds and botanical origin. The antifungal activity was determined by the microdilution technique, using reference microorganisms and clinical isolates. All dermatophytes and yeasts tested were strongly inhibited by different propolis extracts (MICs between 16 and 125 microg mL(-1)). The most susceptible species were Microsporum gypseum, Trichophyton mentagrophytes, and Trichophyton rubrum. The main bioactive compounds were 2',4'-dihydroxy-3'-methoxychalcone 2 and 2',4'-dihydroxychalcone 3. Both displayed strong activity against clinical isolates of T. rubrum and T. mentagrophytes (MICs and MFCs between 1.9 and 2.9 microg mL(-1)). Additionally, galangin 5, pinocembrin 6, and 7-hydroxy-8-methoxyflavanone 9 were isolated from propolis samples and Zuccagnia punctata exudates, showing moderate antifungal activity. This is the first study matching the chemical profile of Z. punctata Cav. exudates with their corresponding propolis, giving strong evidence on the botanical origin of the studied propolis. SN - 1520-5118 UR - https://www.unboundmedicine.com/medline/citation/19916546/Argentinean_propolis_from_Zuccagnia_punctata_Cav___Caesalpinieae__exudates:_phytochemical_characterization_and_antifungal_activity_ L2 - https://doi.org/10.1021/jf902991t DB - PRIME DP - Unbound Medicine ER -