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The dual effects of delta(9)-tetrahydrocannabinol on cholangiocarcinoma cells: anti-invasion activity at low concentration and apoptosis induction at high concentration.
Cancer Invest. 2010 May; 28(4):357-63.CI

Abstract

Currently, only gemcitabine plus platinum demonstrates the considerable activity for cholangiocarcinoma. The anticancer effect of Delta (9)-tetrahydrocannabinol (THC), the principal active component of cannabinoids has been demonstrated in various kinds of cancers. We therefore evaluate the antitumor effects of THC on cholangiocarcinoma cells. Both cholangiocarcinoma cell lines and surgical specimens from cholangiocarcinoma patients expressed cannabinoid receptors. THC inhibited cell proliferation, migration and invasion, and induced cell apoptosis. THC also decreased actin polymerization and reduced tumor cell survival in anoikis assay. pMEK1/2 and pAkt demonstrated the lower extent than untreated cells. Consequently, THC is potentially used to retard cholangiocarcinoma cell growth and metastasis.

Authors+Show Affiliations

Faculty of Pharmacy, Rangsit University, Patumthani, Thailand. surangleelawat@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19916793

Citation

Leelawat, Surang, et al. "The Dual Effects of Delta(9)-tetrahydrocannabinol On Cholangiocarcinoma Cells: Anti-invasion Activity at Low Concentration and Apoptosis Induction at High Concentration." Cancer Investigation, vol. 28, no. 4, 2010, pp. 357-63.
Leelawat S, Leelawat K, Narong S, et al. The dual effects of delta(9)-tetrahydrocannabinol on cholangiocarcinoma cells: anti-invasion activity at low concentration and apoptosis induction at high concentration. Cancer Invest. 2010;28(4):357-63.
Leelawat, S., Leelawat, K., Narong, S., & Matangkasombut, O. (2010). The dual effects of delta(9)-tetrahydrocannabinol on cholangiocarcinoma cells: anti-invasion activity at low concentration and apoptosis induction at high concentration. Cancer Investigation, 28(4), 357-63. https://doi.org/10.3109/07357900903405934
Leelawat S, et al. The Dual Effects of Delta(9)-tetrahydrocannabinol On Cholangiocarcinoma Cells: Anti-invasion Activity at Low Concentration and Apoptosis Induction at High Concentration. Cancer Invest. 2010;28(4):357-63. PubMed PMID: 19916793.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The dual effects of delta(9)-tetrahydrocannabinol on cholangiocarcinoma cells: anti-invasion activity at low concentration and apoptosis induction at high concentration. AU - Leelawat,Surang, AU - Leelawat,Kawin, AU - Narong,Siriluck, AU - Matangkasombut,Oraphan, PY - 2009/11/18/entrez PY - 2009/11/18/pubmed PY - 2010/4/22/medline SP - 357 EP - 63 JF - Cancer investigation JO - Cancer Invest VL - 28 IS - 4 N2 - Currently, only gemcitabine plus platinum demonstrates the considerable activity for cholangiocarcinoma. The anticancer effect of Delta (9)-tetrahydrocannabinol (THC), the principal active component of cannabinoids has been demonstrated in various kinds of cancers. We therefore evaluate the antitumor effects of THC on cholangiocarcinoma cells. Both cholangiocarcinoma cell lines and surgical specimens from cholangiocarcinoma patients expressed cannabinoid receptors. THC inhibited cell proliferation, migration and invasion, and induced cell apoptosis. THC also decreased actin polymerization and reduced tumor cell survival in anoikis assay. pMEK1/2 and pAkt demonstrated the lower extent than untreated cells. Consequently, THC is potentially used to retard cholangiocarcinoma cell growth and metastasis. SN - 1532-4192 UR - https://www.unboundmedicine.com/medline/citation/19916793/The_dual_effects_of_delta_9__tetrahydrocannabinol_on_cholangiocarcinoma_cells:_anti_invasion_activity_at_low_concentration_and_apoptosis_induction_at_high_concentration_ L2 - https://www.tandfonline.com/doi/full/10.3109/07357900903405934 DB - PRIME DP - Unbound Medicine ER -