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Temporal trends in the incidence of Staphylococcus aureus bacteremia in Olmsted County, Minnesota, 1998 to 2005: a population-based study.

Abstract

BACKGROUND

There is a paucity of population-based studies on Staphylococcus aureus bacteremia (SAB) in the United States. We determined the incidence of and trends in SAB in Olmsted County, Minnesota, over an 8-year period.

METHODS

A retrospective, population-based, cohort study was done to evaluate the initial episodes of SAB occurring in adult residents of Olmsted County, Minnesota, from 1 January 1998 through 31 December 2005, using the microbiology databases at Mayo Clinic and Olmsted Medical Center in Rochester, Minnesota.

RESULTS

Of 247 evaluable adult patients with SAB who were included in the incidence calculation, 143 (57.9%) were males, and the median age was 72.1 years (range, 19.5-98.5 years). Episodes of bacteremia were classified according to acquisition type: 58 (23.5%) were nosocomial (N-SAB), 145 (58.7%) were healthcare-associated (HCA-SAB), and 44 (17.8%) were community-acquired (CA-SAB). Methicillin-resistant S. aureus (MRSA) constituted 31.6% of the cases. No community-acquired MRSA bacteremia was noted. The age-adjusted incidence of SAB was 28.3 episodes/100,000 person-years for females and 53.5 episodes/100,000 person-years for males, with an age- and sex-adjusted rate of 38.2 episodes/100,000 person-years. The age- and sex-adjusted incidence of N-SAB, HCA-SAB, and CA-SAB was 9.0, 22.6, and 6.6 episodes/100,000 person-years, respectively. The age- and sex-adjusted incidence of methicillin-susceptible S. aureus was 25.4 episodes/100,000 person-years, and that of MRSA was 12.4 episodes/100,000 person-years. Overall, the incidence rate increased with age but not over the calendar year. The exception was MRSA bacteremia, which increased at a rate of 19.8% (standard error, +/-5.5%) per year during the study.

CONCLUSIONS

The incidence of SAB in adults remained stable in Olmsted County, Minnesota, from 1998 to 2005, but the proportion of episodes due to MRSA significantly increased over the 8-year period.

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  • Authors+Show Affiliations

    ,

    Division of Infectious Diseases, Department of Internal Medicine, School of Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA. welatrouni@kumc.edu

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    MeSH

    Adult
    Aged
    Aged, 80 and over
    Bacteremia
    Cohort Studies
    Female
    Humans
    Incidence
    Male
    Middle Aged
    Minnesota
    Retrospective Studies
    Staphylococcal Infections
    Time Factors

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    19916797

    Citation

    El Atrouni, Wissam I., et al. "Temporal Trends in the Incidence of Staphylococcus Aureus Bacteremia in Olmsted County, Minnesota, 1998 to 2005: a Population-based Study." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 49, no. 12, 2009, pp. e130-8.
    El Atrouni WI, Knoll BM, Lahr BD, et al. Temporal trends in the incidence of Staphylococcus aureus bacteremia in Olmsted County, Minnesota, 1998 to 2005: a population-based study. Clin Infect Dis. 2009;49(12):e130-8.
    El Atrouni, W. I., Knoll, B. M., Lahr, B. D., Eckel-Passow, J. E., Sia, I. G., & Baddour, L. M. (2009). Temporal trends in the incidence of Staphylococcus aureus bacteremia in Olmsted County, Minnesota, 1998 to 2005: a population-based study. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 49(12), pp. e130-8. doi:10.1086/648442.
    El Atrouni WI, et al. Temporal Trends in the Incidence of Staphylococcus Aureus Bacteremia in Olmsted County, Minnesota, 1998 to 2005: a Population-based Study. Clin Infect Dis. 2009 Dec 15;49(12):e130-8. PubMed PMID: 19916797.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Temporal trends in the incidence of Staphylococcus aureus bacteremia in Olmsted County, Minnesota, 1998 to 2005: a population-based study. AU - El Atrouni,Wissam I, AU - Knoll,Bettina M, AU - Lahr,Brian D, AU - Eckel-Passow,Jeanette E, AU - Sia,Irene G, AU - Baddour,Larry M, PY - 2009/11/18/entrez PY - 2009/11/18/pubmed PY - 2010/1/28/medline SP - e130 EP - 8 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin. Infect. Dis. VL - 49 IS - 12 N2 - BACKGROUND: There is a paucity of population-based studies on Staphylococcus aureus bacteremia (SAB) in the United States. We determined the incidence of and trends in SAB in Olmsted County, Minnesota, over an 8-year period. METHODS: A retrospective, population-based, cohort study was done to evaluate the initial episodes of SAB occurring in adult residents of Olmsted County, Minnesota, from 1 January 1998 through 31 December 2005, using the microbiology databases at Mayo Clinic and Olmsted Medical Center in Rochester, Minnesota. RESULTS: Of 247 evaluable adult patients with SAB who were included in the incidence calculation, 143 (57.9%) were males, and the median age was 72.1 years (range, 19.5-98.5 years). Episodes of bacteremia were classified according to acquisition type: 58 (23.5%) were nosocomial (N-SAB), 145 (58.7%) were healthcare-associated (HCA-SAB), and 44 (17.8%) were community-acquired (CA-SAB). Methicillin-resistant S. aureus (MRSA) constituted 31.6% of the cases. No community-acquired MRSA bacteremia was noted. The age-adjusted incidence of SAB was 28.3 episodes/100,000 person-years for females and 53.5 episodes/100,000 person-years for males, with an age- and sex-adjusted rate of 38.2 episodes/100,000 person-years. The age- and sex-adjusted incidence of N-SAB, HCA-SAB, and CA-SAB was 9.0, 22.6, and 6.6 episodes/100,000 person-years, respectively. The age- and sex-adjusted incidence of methicillin-susceptible S. aureus was 25.4 episodes/100,000 person-years, and that of MRSA was 12.4 episodes/100,000 person-years. Overall, the incidence rate increased with age but not over the calendar year. The exception was MRSA bacteremia, which increased at a rate of 19.8% (standard error, +/-5.5%) per year during the study. CONCLUSIONS: The incidence of SAB in adults remained stable in Olmsted County, Minnesota, from 1998 to 2005, but the proportion of episodes due to MRSA significantly increased over the 8-year period. SN - 1537-6591 UR - https://www.unboundmedicine.com/medline/citation/19916797/Temporal_trends_in_the_incidence_of_Staphylococcus_aureus_bacteremia_in_Olmsted_County_Minnesota_1998_to_2005:_a_population_based_study_ L2 - https://academic.oup.com/cid/article-lookup/doi/10.1086/648442 DB - PRIME DP - Unbound Medicine ER -