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A mild favorable effect of soy protein with isoflavones on body composition--a 6-month double-blind randomized placebo-controlled trial among Chinese postmenopausal women.
Int J Obes (Lond). 2010 Feb; 34(2):309-18.IJ

Abstract

BACKGROUND

In vitro and animal studies suggested that soy protein and isoflavones promote weight and body fat loss. However, clinical trials in humans were few and the effects remained uncertain.

OBJECTIVES

To examine whether soy protein with isoflavones and isoflavone extracts exert beneficial effects on body composition among postmenopausal women.

DESIGN

A double-blind randomized placebo-controlled trial was conducted among 180 postmenopausal Chinese women with mild hyperglycemia. After a 2-week adaptation, participants were randomly assigned to one of the three arms to receive 15 g soy protein and 100 mg isoflavones (Soy group), or 15 g milk protein and 100 mg isoflavones (Iso group), or 15 g milk protein (placebo group) on a daily basis for 6 months.

RESULTS

We observed a mild but significant favorable effect of soy protein with isoflavones on the changes of body weight (BW), body mass index, and body fat percentage relative to isoflavone extracts and milk protein after 6-month supplementation. The mean differences of BW between the Soy and the Iso groups were -0.75 kg (95% CI: -1.363 to -0.136, P=0.017), and between the Soy and the placebo groups were -0.60 kg (95% CI: -1.209 to -0.019, P=0.047). The mean difference of change percentage in body fat percentage between the Soy and the Iso groups was -3.74% (95% CI: -6.88 to -0.60%, P=0.02), and between the Soy and the placebo groups was -2.54% (95% CI: -5.69 to 0.12%. P=0.08).

CONCLUSIONS

Six-month supplementation of soy protein with isoflavones had a mild favorable effect on body composition in postmenopausal women.

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Authors+Show Affiliations

Liu ZM
School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong SAR.
Ho SC
No affiliation info available
Chen YM
No affiliation info available
Ho YP
No affiliation info available

MeSH

Adipose TissueAgedAsian Continental Ancestry GroupBlood GlucoseBody CompositionBody Mass IndexBody WeightDietary SupplementsDouble-Blind MethodFemaleHumansHyperglycemiaIsoflavonesMiddle AgedMilk ProteinsPlacebosPostmenopausePrediabetic StateSoybean ProteinsTreatment Outcome

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19918248

Clinical Trial Links

Clinical trial which this article describes

Citation

Liu, Z-m, et al. "A Mild Favorable Effect of Soy Protein With Isoflavones On Body Composition--a 6-month Double-blind Randomized Placebo-controlled Trial Among Chinese Postmenopausal Women." International Journal of Obesity (2005), vol. 34, no. 2, 2010, pp. 309-18.
Liu ZM, Ho SC, Chen YM, et al. A mild favorable effect of soy protein with isoflavones on body composition--a 6-month double-blind randomized placebo-controlled trial among Chinese postmenopausal women. Int J Obes (Lond). 2010;34(2):309-18.
Liu, Z. M., Ho, S. C., Chen, Y. M., & Ho, Y. P. (2010). A mild favorable effect of soy protein with isoflavones on body composition--a 6-month double-blind randomized placebo-controlled trial among Chinese postmenopausal women. International Journal of Obesity (2005), 34(2), 309-18. https://doi.org/10.1038/ijo.2009.236
Liu ZM, et al. A Mild Favorable Effect of Soy Protein With Isoflavones On Body Composition--a 6-month Double-blind Randomized Placebo-controlled Trial Among Chinese Postmenopausal Women. Int J Obes (Lond). 2010;34(2):309-18. PubMed PMID: 19918248.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A mild favorable effect of soy protein with isoflavones on body composition--a 6-month double-blind randomized placebo-controlled trial among Chinese postmenopausal women. AU - Liu,Z-m, AU - Ho,S C, AU - Chen,Y-m, AU - Ho,Y P, Y1 - 2009/11/17/ PY - 2009/11/18/entrez PY - 2009/11/18/pubmed PY - 2010/11/4/medline SP - 309 EP - 18 JF - International journal of obesity (2005) JO - Int J Obes (Lond) VL - 34 IS - 2 N2 - BACKGROUND: In vitro and animal studies suggested that soy protein and isoflavones promote weight and body fat loss. However, clinical trials in humans were few and the effects remained uncertain. OBJECTIVES: To examine whether soy protein with isoflavones and isoflavone extracts exert beneficial effects on body composition among postmenopausal women. DESIGN: A double-blind randomized placebo-controlled trial was conducted among 180 postmenopausal Chinese women with mild hyperglycemia. After a 2-week adaptation, participants were randomly assigned to one of the three arms to receive 15 g soy protein and 100 mg isoflavones (Soy group), or 15 g milk protein and 100 mg isoflavones (Iso group), or 15 g milk protein (placebo group) on a daily basis for 6 months. RESULTS: We observed a mild but significant favorable effect of soy protein with isoflavones on the changes of body weight (BW), body mass index, and body fat percentage relative to isoflavone extracts and milk protein after 6-month supplementation. The mean differences of BW between the Soy and the Iso groups were -0.75 kg (95% CI: -1.363 to -0.136, P=0.017), and between the Soy and the placebo groups were -0.60 kg (95% CI: -1.209 to -0.019, P=0.047). The mean difference of change percentage in body fat percentage between the Soy and the Iso groups was -3.74% (95% CI: -6.88 to -0.60%, P=0.02), and between the Soy and the placebo groups was -2.54% (95% CI: -5.69 to 0.12%. P=0.08). CONCLUSIONS: Six-month supplementation of soy protein with isoflavones had a mild favorable effect on body composition in postmenopausal women. SN - 1476-5497 UR - https://www.unboundmedicine.com/medline/citation/19918248/A_mild_favorable_effect_of_soy_protein_with_isoflavones_on_body_composition__a_6_month_double_blind_randomized_placebo_controlled_trial_among_Chinese_postmenopausal_women_ L2 - https://doi.org/10.1038/ijo.2009.236 DB - PRIME DP - Unbound Medicine ER -