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Asymptomatic diffuse "encephalitic" cerebral toxoplasmosis in a patient with chronic lymphocytic leukemia: case report and review of the literature.
Int J Clin Exp Pathol 2009; 3(1):106-9IJ

Abstract

Opportunistic infections account for the majority of central nervous system lesions in adult immunosuppressed patients. In this setting, toxoplasmosis typically manifests as multiple abscesses readily seen on routine neuroimaging studies. Asymptomatic, widely disseminated Toxoplasma cysts without parenchymal reaction are also recognized. In contrast, widespread parasites in the brain parenchyma with an inflammatory "encephalitic" reaction and little or no necrosis have been reported in only four patients with acquired immune deficiency syndrome (AIDS). We describe a 70 year old male with stage IV chronic lymphocytic leukemia complicated by aplastic anemia. Neurological examination and imaging revealed no significant abnormalities. At autopsy, the brain revealed multifocal cysts and free tachyzoites of Toxoplasma gondii with diffuse microglial nodules and no necrosis. To the best of our knowledge, this case represents the first report of the "encephalitic" form of toxoplasmosis in a non-AIDS patient.

Authors+Show Affiliations

Department of Pathology, Georgetown University Hospital, Washington, DC 20007, USA. mxa212@gunet.georgetown.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

19918334

Citation

Abedalthagafi, Malak, et al. "Asymptomatic Diffuse "encephalitic" Cerebral Toxoplasmosis in a Patient With Chronic Lymphocytic Leukemia: Case Report and Review of the Literature." International Journal of Clinical and Experimental Pathology, vol. 3, no. 1, 2009, pp. 106-9.
Abedalthagafi M, Rushing EJ, Garvin D, et al. Asymptomatic diffuse "encephalitic" cerebral toxoplasmosis in a patient with chronic lymphocytic leukemia: case report and review of the literature. Int J Clin Exp Pathol. 2009;3(1):106-9.
Abedalthagafi, M., Rushing, E. J., Garvin, D., Cheson, B., & Ozdemirli, M. (2009). Asymptomatic diffuse "encephalitic" cerebral toxoplasmosis in a patient with chronic lymphocytic leukemia: case report and review of the literature. International Journal of Clinical and Experimental Pathology, 3(1), pp. 106-9.
Abedalthagafi M, et al. Asymptomatic Diffuse "encephalitic" Cerebral Toxoplasmosis in a Patient With Chronic Lymphocytic Leukemia: Case Report and Review of the Literature. Int J Clin Exp Pathol. 2009 Mar 15;3(1):106-9. PubMed PMID: 19918334.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Asymptomatic diffuse "encephalitic" cerebral toxoplasmosis in a patient with chronic lymphocytic leukemia: case report and review of the literature. AU - Abedalthagafi,Malak, AU - Rushing,Elisabeth J, AU - Garvin,David, AU - Cheson,Bruce, AU - Ozdemirli,Metin, Y1 - 2009/03/15/ PY - 2009/02/08/received PY - 2009/03/04/accepted PY - 2009/11/18/entrez PY - 2009/11/18/pubmed PY - 2010/3/3/medline KW - Toxoplasma KW - Toxoplasmosis KW - central nervous system KW - chronic lymphocytic leukemia SP - 106 EP - 9 JF - International journal of clinical and experimental pathology JO - Int J Clin Exp Pathol VL - 3 IS - 1 N2 - Opportunistic infections account for the majority of central nervous system lesions in adult immunosuppressed patients. In this setting, toxoplasmosis typically manifests as multiple abscesses readily seen on routine neuroimaging studies. Asymptomatic, widely disseminated Toxoplasma cysts without parenchymal reaction are also recognized. In contrast, widespread parasites in the brain parenchyma with an inflammatory "encephalitic" reaction and little or no necrosis have been reported in only four patients with acquired immune deficiency syndrome (AIDS). We describe a 70 year old male with stage IV chronic lymphocytic leukemia complicated by aplastic anemia. Neurological examination and imaging revealed no significant abnormalities. At autopsy, the brain revealed multifocal cysts and free tachyzoites of Toxoplasma gondii with diffuse microglial nodules and no necrosis. To the best of our knowledge, this case represents the first report of the "encephalitic" form of toxoplasmosis in a non-AIDS patient. SN - 1936-2625 UR - https://www.unboundmedicine.com/medline/citation/19918334/Asymptomatic_diffuse_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19918334/ DB - PRIME DP - Unbound Medicine ER -