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[Allogeneic hematopoietic stem cell transplantation from HLA one-locus-mismatched related donors].
Gan To Kagaku Ryoho. 2009 Nov; 36(11):1845-9.GT

Abstract

Fourteen patients who received allogeneic hematopoietic stem cell transplantation (HSCT) from a serologically HLA one mismatched related donor (MMRD) between November 1987 and July 2003, were compared with HSCT from matched sibling donor (MSD) (n=142) or matched unrelated donor (MUD) (n=78). Cumulative incidence of acute graft-versus-host disease (GVHD) in patients with MMRD was significantly higher than in those with MSD, but was not different from that in those with MUD. There was no difference in the incidence of extensive type chronic GVHD in HSCT according to donor type. Overall survival (OS) at 5-years in patients with MMRD, MSD and MUD was 42.8%, 55.6% and 44.3%, respectively. The presence of acute GVHD and disease status at HSCT were identified as risk factors for overall survival by multivariate analysis. Acute GVHD was a risk factor for prognosis in patients with MSD and MUD, but not in those with MMRD. It was confirmed that the therapeutic results could be obtained in HSCT from MMRD as well as MUD.

Authors+Show Affiliations

Dept. of Hematology, Kanagawa Cancer Center.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

jpn

PubMed ID

19920386

Citation

Hyo, Rie, et al. "[Allogeneic Hematopoietic Stem Cell Transplantation From HLA One-locus-mismatched Related Donors]." Gan to Kagaku Ryoho. Cancer & Chemotherapy, vol. 36, no. 11, 2009, pp. 1845-9.
Hyo R, Taguchi J, Kamijo A, et al. [Allogeneic hematopoietic stem cell transplantation from HLA one-locus-mismatched related donors]. Gan To Kagaku Ryoho. 2009;36(11):1845-9.
Hyo, R., Taguchi, J., Kamijo, A., Tanaka, M., Hashimoto, C., Kanamori, H., Motomura, S., Maruta, A., & Ishigatsubo, Y. (2009). [Allogeneic hematopoietic stem cell transplantation from HLA one-locus-mismatched related donors]. Gan to Kagaku Ryoho. Cancer & Chemotherapy, 36(11), 1845-9.
Hyo R, et al. [Allogeneic Hematopoietic Stem Cell Transplantation From HLA One-locus-mismatched Related Donors]. Gan To Kagaku Ryoho. 2009;36(11):1845-9. PubMed PMID: 19920386.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Allogeneic hematopoietic stem cell transplantation from HLA one-locus-mismatched related donors]. AU - Hyo,Rie, AU - Taguchi,Jun, AU - Kamijo,Aki, AU - Tanaka,Masatsugu, AU - Hashimoto,Chizuko, AU - Kanamori,Heiwa, AU - Motomura,Shigeki, AU - Maruta,Atsuo, AU - Ishigatsubo,Yoshiaki, PY - 2009/11/19/entrez PY - 2009/11/19/pubmed PY - 2009/12/30/medline SP - 1845 EP - 9 JF - Gan to kagaku ryoho. Cancer & chemotherapy JO - Gan To Kagaku Ryoho VL - 36 IS - 11 N2 - Fourteen patients who received allogeneic hematopoietic stem cell transplantation (HSCT) from a serologically HLA one mismatched related donor (MMRD) between November 1987 and July 2003, were compared with HSCT from matched sibling donor (MSD) (n=142) or matched unrelated donor (MUD) (n=78). Cumulative incidence of acute graft-versus-host disease (GVHD) in patients with MMRD was significantly higher than in those with MSD, but was not different from that in those with MUD. There was no difference in the incidence of extensive type chronic GVHD in HSCT according to donor type. Overall survival (OS) at 5-years in patients with MMRD, MSD and MUD was 42.8%, 55.6% and 44.3%, respectively. The presence of acute GVHD and disease status at HSCT were identified as risk factors for overall survival by multivariate analysis. Acute GVHD was a risk factor for prognosis in patients with MSD and MUD, but not in those with MMRD. It was confirmed that the therapeutic results could be obtained in HSCT from MMRD as well as MUD. SN - 0385-0684 UR - https://www.unboundmedicine.com/medline/citation/19920386/[Allogeneic_hematopoietic_stem_cell_transplantation_from_HLA_one_locus_mismatched_related_donors]_ L2 - http://www.pieronline.jp/openurl?issn=0385-0684&volume=36&issue=11&spage=1845 DB - PRIME DP - Unbound Medicine ER -