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Breastfeeding reduces breast cancer risk: a case-control study in Tunisia.

Abstract

In this report, we examined the relationship between mother's breastfeeding history and her risk of breast cancer, in a case-control study in Tunisia between 2006 and 2009. About 400 breast cancer cases and 400 controls were included. Cases and controls were interviewed using a standardized structured questionnaire to obtain information on breastfeeding and other risk factors. Mean duration of breastfeeding per child was significantly associated with a reduced risk of breast cancer for women who breastfed for > 24 months per child. The OR was 0.46 (95% CI, 0.28-0.76) when compared those who breastfed for < 6 months. The test for trend was significant (p = 0.01). A significantly reduced risk of breast cancer was found for those whose lifetime duration of breastfeeding was 73-108 months (OR = 0.65, 95% CI, 0.36- 1.18) and for those who breastfed for > or = 109 months (OR = 0.42, 95% CI, 0.20-0.84). Stratification by menopausal status showed a reduced risk of breast cancer associated with a longer duration of breastfeeding for both pre- and postmenopausal women. The risk reduction was more consistent for lifetime duration of breastfeeding, the test for trend being significant for both pre- (p = 0.03) and postmenopausal (p = 0.01) women. These results support an inverse association between breastfeeding and breast cancer risk.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Medical Oncology, CHU Farhat Hached, Sousse, Tunisia. awatefmsolly@yahoo.fr

    , , , , , ,

    Source

    Cancer causes & control : CCC 21:3 2010 Mar pg 393-7

    MeSH

    Adult
    Breast Feeding
    Breast Neoplasms
    Case-Control Studies
    Confidence Intervals
    Female
    Humans
    Menopause
    Middle Aged
    Odds Ratio
    Postmenopause
    Risk Assessment
    Risk Reduction Behavior
    Tunisia
    Women's Health

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    19921444

    Citation

    Awatef, Msolly, et al. "Breastfeeding Reduces Breast Cancer Risk: a Case-control Study in Tunisia." Cancer Causes & Control : CCC, vol. 21, no. 3, 2010, pp. 393-7.
    Awatef M, Olfa G, Imed H, et al. Breastfeeding reduces breast cancer risk: a case-control study in Tunisia. Cancer Causes Control. 2010;21(3):393-7.
    Awatef, M., Olfa, G., Imed, H., Kacem, M., Imen, C., Rim, C., ... Slim, B. A. (2010). Breastfeeding reduces breast cancer risk: a case-control study in Tunisia. Cancer Causes & Control : CCC, 21(3), pp. 393-7. doi:10.1007/s10552-009-9471-3.
    Awatef M, et al. Breastfeeding Reduces Breast Cancer Risk: a Case-control Study in Tunisia. Cancer Causes Control. 2010;21(3):393-7. PubMed PMID: 19921444.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Breastfeeding reduces breast cancer risk: a case-control study in Tunisia. AU - Awatef,Msolly, AU - Olfa,Gharbi, AU - Imed,Harrabi, AU - Kacem,Mahmoudi, AU - Imen,Chabchoub, AU - Rim,Chafai, AU - Mohamed,Bibi, AU - Slim,Ben Ahmed, PY - 2009/07/01/received PY - 2009/11/03/accepted PY - 2009/11/19/entrez PY - 2009/11/19/pubmed PY - 2010/6/5/medline SP - 393 EP - 7 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 21 IS - 3 N2 - In this report, we examined the relationship between mother's breastfeeding history and her risk of breast cancer, in a case-control study in Tunisia between 2006 and 2009. About 400 breast cancer cases and 400 controls were included. Cases and controls were interviewed using a standardized structured questionnaire to obtain information on breastfeeding and other risk factors. Mean duration of breastfeeding per child was significantly associated with a reduced risk of breast cancer for women who breastfed for > 24 months per child. The OR was 0.46 (95% CI, 0.28-0.76) when compared those who breastfed for < 6 months. The test for trend was significant (p = 0.01). A significantly reduced risk of breast cancer was found for those whose lifetime duration of breastfeeding was 73-108 months (OR = 0.65, 95% CI, 0.36- 1.18) and for those who breastfed for > or = 109 months (OR = 0.42, 95% CI, 0.20-0.84). Stratification by menopausal status showed a reduced risk of breast cancer associated with a longer duration of breastfeeding for both pre- and postmenopausal women. The risk reduction was more consistent for lifetime duration of breastfeeding, the test for trend being significant for both pre- (p = 0.03) and postmenopausal (p = 0.01) women. These results support an inverse association between breastfeeding and breast cancer risk. SN - 1573-7225 UR - https://www.unboundmedicine.com/medline/citation/19921444/Breastfeeding_reduces_breast_cancer_risk:_a_case_control_study__in_Tunisia_ L2 - https://doi.org/10.1007/s10552-009-9471-3 DB - PRIME DP - Unbound Medicine ER -