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Continuous granulation with a twin-screw extruder: impact of material throughput.
Pharm Dev Technol. 2010 Sep-Oct; 15(5):518-25.PD

Abstract

Agglomeration behavior of a twin-screw extruder at different material throughputs was investigated. Water insoluble dicalcium phosphate and the binder povidone were agglomerated with demineralized water with five different screw configurations using conveying-, kneading- or combing mixer elements. Increasing material throughput mainly had an effect on the particle size of granules. Due to a higher filling degree of the barrel, the particle size was higher at increased material throughput. Granule porosity was generally influenced by screw element type. With a higher element dispersivity granule porosity and friability decreased. Compression of the different granule batches led to comparable tablet properties. A simple scale up in order to increase batch size can be realized by increasing either production time at given material throughput or material throughput.

Authors+Show Affiliations

Institute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine-University, Duesseldorf, Germany.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19921959

Citation

Djuric, Dejan, and Peter Kleinebudde. "Continuous Granulation With a Twin-screw Extruder: Impact of Material Throughput." Pharmaceutical Development and Technology, vol. 15, no. 5, 2010, pp. 518-25.
Djuric D, Kleinebudde P. Continuous granulation with a twin-screw extruder: impact of material throughput. Pharm Dev Technol. 2010;15(5):518-25.
Djuric, D., & Kleinebudde, P. (2010). Continuous granulation with a twin-screw extruder: impact of material throughput. Pharmaceutical Development and Technology, 15(5), 518-25. https://doi.org/10.3109/10837450903397578
Djuric D, Kleinebudde P. Continuous Granulation With a Twin-screw Extruder: Impact of Material Throughput. Pharm Dev Technol. 2010 Sep-Oct;15(5):518-25. PubMed PMID: 19921959.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Continuous granulation with a twin-screw extruder: impact of material throughput. AU - Djuric,Dejan, AU - Kleinebudde,Peter, PY - 2009/11/20/entrez PY - 2009/11/20/pubmed PY - 2010/12/14/medline SP - 518 EP - 25 JF - Pharmaceutical development and technology JO - Pharm Dev Technol VL - 15 IS - 5 N2 - Agglomeration behavior of a twin-screw extruder at different material throughputs was investigated. Water insoluble dicalcium phosphate and the binder povidone were agglomerated with demineralized water with five different screw configurations using conveying-, kneading- or combing mixer elements. Increasing material throughput mainly had an effect on the particle size of granules. Due to a higher filling degree of the barrel, the particle size was higher at increased material throughput. Granule porosity was generally influenced by screw element type. With a higher element dispersivity granule porosity and friability decreased. Compression of the different granule batches led to comparable tablet properties. A simple scale up in order to increase batch size can be realized by increasing either production time at given material throughput or material throughput. SN - 1097-9867 UR - https://www.unboundmedicine.com/medline/citation/19921959/Continuous_granulation_with_a_twin_screw_extruder:_impact_of_material_throughput_ L2 - https://www.tandfonline.com/doi/full/10.3109/10837450903397578 DB - PRIME DP - Unbound Medicine ER -