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Salvage high-intensity focused ultrasound for biopsy-confirmed local recurrence of prostate cancer after radical prostatectomy.
BJU Int. 2010 Jun; 105(12):1642-5.BI

Abstract

OBJECTIVE

To present experience in high-intensity focused ultrasound (HIFU) used as a salvage therapy for biopsy-confirmed local recurrence at the vesico-urethral anastomosis after radical prostatectomy (RP).

PATIENTS AND METHODS

From July 2006, four patients diagnosed with prostate cancer recurrence after RP were treated with HIFU, with or without salvage radiotherapy, using the Sonablate 500 (Focus Surgery, IN, USA). Biochemical failure was defined as in increase in prostate-specific antigen (PSA) level of >0.2 ng/mL. No patients received any adjuvant therapy after HIFU therapy before reporting failure.

RESULTS

The mean age and initial PSA level before RP was 74 years and 10.0 ng/mL, respectively. After RP, one patient was stage T2aN0M0, two were stage T3N0M0 and the last had an unknown pathological stage. Three patients received external beam radiotherapy as salvage therapy after RP. The mean PSA level before HIFU, tumour volume at the vesico-urethral lesion and operative duration were 4.3 ng/mL, 4.6 mL and 27 min, respectively. Adenocarcinomas were confirmed by biopsy of the tumour at the vesico-urethral anastomotic lesion before HIFU. At 24 months of follow-up, patients 2 and 4 were classified a biochemically disease-free. Biopsies at the anastomotic site after HIFU in three patients showed no malignancy, with fibrosis. There were no complications.

CONCLUSION

Salvage HIFU for patients with recurrence after RP is feasible, even though they received salvage radiotherapy before HIFU. More patients and a longer follow-up are needed to evaluate the safety and oncological adequacy of this new approach.

Authors+Show Affiliations

Department of Urology, Tokai University Hachioji Hospital, Hachioji, Tokyo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19922544

Citation

Murota-Kawano, Akiko, et al. "Salvage High-intensity Focused Ultrasound for Biopsy-confirmed Local Recurrence of Prostate Cancer After Radical Prostatectomy." BJU International, vol. 105, no. 12, 2010, pp. 1642-5.
Murota-Kawano A, Nakano M, Hongo S, et al. Salvage high-intensity focused ultrasound for biopsy-confirmed local recurrence of prostate cancer after radical prostatectomy. BJU Int. 2010;105(12):1642-5.
Murota-Kawano, A., Nakano, M., Hongo, S., Shoji, S., Nagata, Y., & Uchida, T. (2010). Salvage high-intensity focused ultrasound for biopsy-confirmed local recurrence of prostate cancer after radical prostatectomy. BJU International, 105(12), 1642-5. https://doi.org/10.1111/j.1464-410X.2009.08990.x
Murota-Kawano A, et al. Salvage High-intensity Focused Ultrasound for Biopsy-confirmed Local Recurrence of Prostate Cancer After Radical Prostatectomy. BJU Int. 2010;105(12):1642-5. PubMed PMID: 19922544.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Salvage high-intensity focused ultrasound for biopsy-confirmed local recurrence of prostate cancer after radical prostatectomy. AU - Murota-Kawano,Akiko, AU - Nakano,Mayura, AU - Hongo,Sachiko, AU - Shoji,Sunao, AU - Nagata,Yoshihiro, AU - Uchida,Toyoaki, Y1 - 2009/11/17/ PY - 2009/11/20/entrez PY - 2009/11/20/pubmed PY - 2010/7/16/medline SP - 1642 EP - 5 JF - BJU international JO - BJU Int VL - 105 IS - 12 N2 - OBJECTIVE: To present experience in high-intensity focused ultrasound (HIFU) used as a salvage therapy for biopsy-confirmed local recurrence at the vesico-urethral anastomosis after radical prostatectomy (RP). PATIENTS AND METHODS: From July 2006, four patients diagnosed with prostate cancer recurrence after RP were treated with HIFU, with or without salvage radiotherapy, using the Sonablate 500 (Focus Surgery, IN, USA). Biochemical failure was defined as in increase in prostate-specific antigen (PSA) level of >0.2 ng/mL. No patients received any adjuvant therapy after HIFU therapy before reporting failure. RESULTS: The mean age and initial PSA level before RP was 74 years and 10.0 ng/mL, respectively. After RP, one patient was stage T2aN0M0, two were stage T3N0M0 and the last had an unknown pathological stage. Three patients received external beam radiotherapy as salvage therapy after RP. The mean PSA level before HIFU, tumour volume at the vesico-urethral lesion and operative duration were 4.3 ng/mL, 4.6 mL and 27 min, respectively. Adenocarcinomas were confirmed by biopsy of the tumour at the vesico-urethral anastomotic lesion before HIFU. At 24 months of follow-up, patients 2 and 4 were classified a biochemically disease-free. Biopsies at the anastomotic site after HIFU in three patients showed no malignancy, with fibrosis. There were no complications. CONCLUSION: Salvage HIFU for patients with recurrence after RP is feasible, even though they received salvage radiotherapy before HIFU. More patients and a longer follow-up are needed to evaluate the safety and oncological adequacy of this new approach. SN - 1464-410X UR - https://www.unboundmedicine.com/medline/citation/19922544/Salvage_high_intensity_focused_ultrasound_for_biopsy_confirmed_local_recurrence_of_prostate_cancer_after_radical_prostatectomy_ L2 - https://doi.org/10.1111/j.1464-410X.2009.08990.x DB - PRIME DP - Unbound Medicine ER -