Tags

Type your tag names separated by a space and hit enter

Longitudinal increase in gamma-glutamyltransferase within the reference interval predicts metabolic syndrome in middle-aged Korean men.
Metabolism 2010; 59(5):683-9M

Abstract

In the absence of existing research, we examined the association between longitudinal changes in serum gamma-glutamyltransferase (GGT) levels and the risk for metabolic syndrome (MetS). A MetS-free cohort of 9148 healthy male workers, who had participated in a health checkup program in 2002, was followed until September 2007. Metabolic syndrome was defined according to the modified National Cholesterol Education Program, using body mass index instead of waist circumference. Standard Cox proportional hazards and time-dependent Cox models were performed. During 37 663.4 person-years of follow-up, 1056 men developed MetS. The risk of incident MetS increased across the baseline GGT quartiles, even after further updating GGT values during the follow-up. A longitudinal increase in GGT as a time-dependent variable as well as a non-time-dependent variable was significantly related to MetS after adjusting for age plus the elapsed time from visit 1 to visit 2, baseline MetS traits, uric acid, regular exercise, alcohol consumption, and smoking. Even within the GGT reference interval (<40 U/L), the fourth quartile of GGT change predicted the development of MetS (adjusted hazard risk, 1.61; 95% confidence interval, 1.26-2.07). Furthermore, these associations were consistently observed within the subgroups-those with body mass index less than 23 kg/m(2), C-reactive protein less than 3.0 mg/L, homeostasis model assessment of insulin resistance less than 2.04, alcohol intake not exceeding 20 g/d, alanine aminotransferase less than 35 U/L, an absence of ultrasonographically detected fatty liver, and an absence of any MetS traits. A longitudinal increase in the GGT level, even within the GGT reference interval, may be an independent predictor for MetS, regardless of the baseline GGT.

Authors+Show Affiliations

Department of Occupational Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul, South Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19922966

Citation

Ryu, Seungho, et al. "Longitudinal Increase in Gamma-glutamyltransferase Within the Reference Interval Predicts Metabolic Syndrome in Middle-aged Korean Men." Metabolism: Clinical and Experimental, vol. 59, no. 5, 2010, pp. 683-9.
Ryu S, Chang Y, Woo HY, et al. Longitudinal increase in gamma-glutamyltransferase within the reference interval predicts metabolic syndrome in middle-aged Korean men. Metab Clin Exp. 2010;59(5):683-9.
Ryu, S., Chang, Y., Woo, H. Y., Yoo, S. H., Choi, N. K., Lee, W. Y., ... Song, J. (2010). Longitudinal increase in gamma-glutamyltransferase within the reference interval predicts metabolic syndrome in middle-aged Korean men. Metabolism: Clinical and Experimental, 59(5), pp. 683-9. doi:10.1016/j.metabol.2009.08.024.
Ryu S, et al. Longitudinal Increase in Gamma-glutamyltransferase Within the Reference Interval Predicts Metabolic Syndrome in Middle-aged Korean Men. Metab Clin Exp. 2010;59(5):683-9. PubMed PMID: 19922966.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Longitudinal increase in gamma-glutamyltransferase within the reference interval predicts metabolic syndrome in middle-aged Korean men. AU - Ryu,Seungho, AU - Chang,Yoosoo, AU - Woo,Hee-Yeon, AU - Yoo,Sang-Ho, AU - Choi,Nam-Kyong, AU - Lee,Won-Young, AU - Kim,Inah, AU - Song,Jaechul, Y1 - 2009/11/18/ PY - 2008/09/05/received PY - 2009/08/19/accepted PY - 2009/11/20/entrez PY - 2009/11/20/pubmed PY - 2010/5/4/medline SP - 683 EP - 9 JF - Metabolism: clinical and experimental JO - Metab. Clin. Exp. VL - 59 IS - 5 N2 - In the absence of existing research, we examined the association between longitudinal changes in serum gamma-glutamyltransferase (GGT) levels and the risk for metabolic syndrome (MetS). A MetS-free cohort of 9148 healthy male workers, who had participated in a health checkup program in 2002, was followed until September 2007. Metabolic syndrome was defined according to the modified National Cholesterol Education Program, using body mass index instead of waist circumference. Standard Cox proportional hazards and time-dependent Cox models were performed. During 37 663.4 person-years of follow-up, 1056 men developed MetS. The risk of incident MetS increased across the baseline GGT quartiles, even after further updating GGT values during the follow-up. A longitudinal increase in GGT as a time-dependent variable as well as a non-time-dependent variable was significantly related to MetS after adjusting for age plus the elapsed time from visit 1 to visit 2, baseline MetS traits, uric acid, regular exercise, alcohol consumption, and smoking. Even within the GGT reference interval (<40 U/L), the fourth quartile of GGT change predicted the development of MetS (adjusted hazard risk, 1.61; 95% confidence interval, 1.26-2.07). Furthermore, these associations were consistently observed within the subgroups-those with body mass index less than 23 kg/m(2), C-reactive protein less than 3.0 mg/L, homeostasis model assessment of insulin resistance less than 2.04, alcohol intake not exceeding 20 g/d, alanine aminotransferase less than 35 U/L, an absence of ultrasonographically detected fatty liver, and an absence of any MetS traits. A longitudinal increase in the GGT level, even within the GGT reference interval, may be an independent predictor for MetS, regardless of the baseline GGT. SN - 1532-8600 UR - https://www.unboundmedicine.com/medline/citation/19922966/Longitudinal_increase_in_gamma_glutamyltransferase_within_the_reference_interval_predicts_metabolic_syndrome_in_middle_aged_Korean_men_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(09)00401-6 DB - PRIME DP - Unbound Medicine ER -