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Linoleic acid is associated with lower long-chain n-6 and n-3 fatty acids in red blood cell lipids of Canadian pregnant women.

Abstract

BACKGROUND

Arachidonic (ARA), eicosapentaenoic (EPA), and docosahexaenoic (DHA) acids are important in membrane glycerophospholipids. Higher maternal blood ARA, EPA, and DHA concentrations in gestation are associated with higher maternal-to-fetal transfer of ARA, EPA, and DHA, respectively, which emphasizes the importance of maternal fatty acid status in gestation. As in the brain, red blood cell (RBC) ethanolamine phosphoglycerides (EPGs) are high in plasmalogen, ARA, and DHA.

OBJECTIVE

We determined the relation between dietary n-6 (omega-6) and n-3 (omega-3) fatty acid intakes and n-6 and n-3 fatty acids in RBC EPGs and phosphatidylcholine in near-term pregnant women.

DESIGN

The subjects were 105 healthy Canadian pregnant (36 wk gestation) women. Fatty acid intakes were estimated by food-frequency questionnaire, and fasting venous blood samples were collected.

RESULTS

DHA and EPA intakes were positively associated with RBC EPG and phosphatidylcholine concentrations of DHA (rho = 0.309 and 0.369, respectively; P < 0.001) and EPA (rho = 0.391 and 0.228, respectively; P < 0.001) and inversely associated with RBC EPG 22:4n-6 and 22:5n-6 (P < 0.001). In RBCs, concentrations of linoleic acid (LA, 18:2n-6) were inversely associated with DHA, EPA, and ARA, respectively, in EPGs (r = -0.432, P < 0.01; r = -0.201, P < 0.04; and r = -0.303, P < 0.01) and phosphatidylcholine (r = -0.460, -0.490, and -0.604; P < 0.01 for all).

CONCLUSIONS

Membrane fatty acids are influenced by the amount and balance of fatty acid substrates. Our results suggest the competitive interaction of LA with ARA, EPA, and DHA, with no evidence that higher LA increases ARA. Biochemical indicators to suggest that DHA is limiting are present in our population. This trial was registered at clinicaltrials.gov as NCT00620672.

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  • Authors+Show Affiliations

    ,

    Nutrition and Metabolism Program, Child and Family Research Institute, Department of Paediatrics, Faculty of Medicine, University of British Columbia, Vancouver, Canada.

    Source

    MeSH

    Adult
    Dietary Fats
    Erythrocytes
    Ethanolamines
    Fatty Acids
    Fatty Acids, Omega-3
    Fatty Acids, Omega-6
    Female
    Glycerophospholipids
    Humans
    Lecithins
    Linoleic Acid
    Maternal-Fetal Exchange
    Patient Selection
    Pregnancy
    Pregnancy Trimester, Third
    Young Adult

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    19923368

    Citation

    Friesen, Russell W., and Sheila M. Innis. "Linoleic Acid Is Associated With Lower Long-chain N-6 and N-3 Fatty Acids in Red Blood Cell Lipids of Canadian Pregnant Women." The American Journal of Clinical Nutrition, vol. 91, no. 1, 2010, pp. 23-31.
    Friesen RW, Innis SM. Linoleic acid is associated with lower long-chain n-6 and n-3 fatty acids in red blood cell lipids of Canadian pregnant women. Am J Clin Nutr. 2010;91(1):23-31.
    Friesen, R. W., & Innis, S. M. (2010). Linoleic acid is associated with lower long-chain n-6 and n-3 fatty acids in red blood cell lipids of Canadian pregnant women. The American Journal of Clinical Nutrition, 91(1), pp. 23-31. doi:10.3945/ajcn.2009.28206.
    Friesen RW, Innis SM. Linoleic Acid Is Associated With Lower Long-chain N-6 and N-3 Fatty Acids in Red Blood Cell Lipids of Canadian Pregnant Women. Am J Clin Nutr. 2010;91(1):23-31. PubMed PMID: 19923368.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Linoleic acid is associated with lower long-chain n-6 and n-3 fatty acids in red blood cell lipids of Canadian pregnant women. AU - Friesen,Russell W, AU - Innis,Sheila M, Y1 - 2009/11/18/ PY - 2009/11/20/entrez PY - 2009/11/20/pubmed PY - 2010/1/14/medline SP - 23 EP - 31 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 91 IS - 1 N2 - BACKGROUND: Arachidonic (ARA), eicosapentaenoic (EPA), and docosahexaenoic (DHA) acids are important in membrane glycerophospholipids. Higher maternal blood ARA, EPA, and DHA concentrations in gestation are associated with higher maternal-to-fetal transfer of ARA, EPA, and DHA, respectively, which emphasizes the importance of maternal fatty acid status in gestation. As in the brain, red blood cell (RBC) ethanolamine phosphoglycerides (EPGs) are high in plasmalogen, ARA, and DHA. OBJECTIVE: We determined the relation between dietary n-6 (omega-6) and n-3 (omega-3) fatty acid intakes and n-6 and n-3 fatty acids in RBC EPGs and phosphatidylcholine in near-term pregnant women. DESIGN: The subjects were 105 healthy Canadian pregnant (36 wk gestation) women. Fatty acid intakes were estimated by food-frequency questionnaire, and fasting venous blood samples were collected. RESULTS: DHA and EPA intakes were positively associated with RBC EPG and phosphatidylcholine concentrations of DHA (rho = 0.309 and 0.369, respectively; P < 0.001) and EPA (rho = 0.391 and 0.228, respectively; P < 0.001) and inversely associated with RBC EPG 22:4n-6 and 22:5n-6 (P < 0.001). In RBCs, concentrations of linoleic acid (LA, 18:2n-6) were inversely associated with DHA, EPA, and ARA, respectively, in EPGs (r = -0.432, P < 0.01; r = -0.201, P < 0.04; and r = -0.303, P < 0.01) and phosphatidylcholine (r = -0.460, -0.490, and -0.604; P < 0.01 for all). CONCLUSIONS: Membrane fatty acids are influenced by the amount and balance of fatty acid substrates. Our results suggest the competitive interaction of LA with ARA, EPA, and DHA, with no evidence that higher LA increases ARA. Biochemical indicators to suggest that DHA is limiting are present in our population. This trial was registered at clinicaltrials.gov as NCT00620672. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/19923368/Linoleic_acid_is_associated_with_lower_long_chain_n_6_and_n_3_fatty_acids_in_red_blood_cell_lipids_of_Canadian_pregnant_women_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.2009.28206 DB - PRIME DP - Unbound Medicine ER -