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Effect of oral isoflavone supplementation on vascular endothelial function in postmenopausal women: a meta-analysis of randomized placebo-controlled trials.

Abstract

BACKGROUND

The effect of isoflavone on endothelial function in postmenopausal women is controversial.

OBJECTIVE

The objective of this study was to evaluate the effect of oral isoflavone supplementation on endothelial function, as measured by flow-mediated dilation (FMD), in postmenopausal women.

DESIGN

A meta-analysis of randomized placebo-controlled trials was conducted to evaluate the effect of oral isoflavone supplementation on endothelial function in postmenopausal women. Trials were searched in PubMed, Embase, the Cochrane Library database, and reviews and reference lists of relevant articles. Summary estimates of weighted mean differences (WMDs) and 95% CIs were obtained by using random-effects models. Meta-regression and subgroup analyses were performed to identify the source of heterogeneity.

RESULTS

A total of 9 trials were reviewed in the present meta-analysis. Overall, the results of the 9 trials showed that isoflavone significantly increased FMD (WMD: 1.75%; 95% CI: 0.83%, 2.67%; P = 0.0002). Meta-regression analysis indicated that the age-adjusted baseline FMD was inversely related to effect size. Subgroup analysis showed that oral supplementation of isoflavone had no influence on FMD if the age-adjusted baseline FMD was > or = 5.2% (4 trials; WMD: 0.24%; 95% CI: -0.94%, 1.42%; P = 0.69). This improvement seemed to be significant when the age-adjusted baseline FMD levels were <5.2% (5 trials; WMD: 2.22%; 95% CI: 1.15%, 3.30%; P < 0.0001), although significant heterogeneity was still detected in this low-baseline-FMD subgroup.

CONCLUSIONS

Oral isoflavone supplementation does not improve endothelial function in postmenopausal women with high baseline FMD levels but leads to significant improvement in women with low baseline FMD levels.

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  • Authors+Show Affiliations

    ,

    Key Laboratory for Clinical Cardiovascular Genetics & Sino-German Laboratory for Molecular Medicine, Cardiovascular Institute & FuWai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

    , , , , ,

    Source

    MeSH

    Cardiovascular Diseases
    Dietary Supplements
    Endothelium, Vascular
    Female
    Humans
    Isoflavones
    Middle Aged
    Placebos
    Postmenopause
    Randomized Controlled Trials as Topic
    Vasodilation

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    19923372

    Citation

    Li, Shao-Hua, et al. "Effect of Oral Isoflavone Supplementation On Vascular Endothelial Function in Postmenopausal Women: a Meta-analysis of Randomized Placebo-controlled Trials." The American Journal of Clinical Nutrition, vol. 91, no. 2, 2010, pp. 480-6.
    Li SH, Liu XX, Bai YY, et al. Effect of oral isoflavone supplementation on vascular endothelial function in postmenopausal women: a meta-analysis of randomized placebo-controlled trials. Am J Clin Nutr. 2010;91(2):480-6.
    Li, S. H., Liu, X. X., Bai, Y. Y., Wang, X. J., Sun, K., Chen, J. Z., & Hui, R. T. (2010). Effect of oral isoflavone supplementation on vascular endothelial function in postmenopausal women: a meta-analysis of randomized placebo-controlled trials. The American Journal of Clinical Nutrition, 91(2), pp. 480-6. doi:10.3945/ajcn.2009.28203.
    Li SH, et al. Effect of Oral Isoflavone Supplementation On Vascular Endothelial Function in Postmenopausal Women: a Meta-analysis of Randomized Placebo-controlled Trials. Am J Clin Nutr. 2010;91(2):480-6. PubMed PMID: 19923372.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effect of oral isoflavone supplementation on vascular endothelial function in postmenopausal women: a meta-analysis of randomized placebo-controlled trials. AU - Li,Shao-Hua, AU - Liu,Xu-Xia, AU - Bai,Yong-Yi, AU - Wang,Xiao-Jian, AU - Sun,Kai, AU - Chen,Jing-Zhou, AU - Hui,Ru-Tai, Y1 - 2009/11/18/ PY - 2009/11/20/entrez PY - 2009/11/20/pubmed PY - 2010/2/23/medline SP - 480 EP - 6 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 91 IS - 2 N2 - BACKGROUND: The effect of isoflavone on endothelial function in postmenopausal women is controversial. OBJECTIVE: The objective of this study was to evaluate the effect of oral isoflavone supplementation on endothelial function, as measured by flow-mediated dilation (FMD), in postmenopausal women. DESIGN: A meta-analysis of randomized placebo-controlled trials was conducted to evaluate the effect of oral isoflavone supplementation on endothelial function in postmenopausal women. Trials were searched in PubMed, Embase, the Cochrane Library database, and reviews and reference lists of relevant articles. Summary estimates of weighted mean differences (WMDs) and 95% CIs were obtained by using random-effects models. Meta-regression and subgroup analyses were performed to identify the source of heterogeneity. RESULTS: A total of 9 trials were reviewed in the present meta-analysis. Overall, the results of the 9 trials showed that isoflavone significantly increased FMD (WMD: 1.75%; 95% CI: 0.83%, 2.67%; P = 0.0002). Meta-regression analysis indicated that the age-adjusted baseline FMD was inversely related to effect size. Subgroup analysis showed that oral supplementation of isoflavone had no influence on FMD if the age-adjusted baseline FMD was > or = 5.2% (4 trials; WMD: 0.24%; 95% CI: -0.94%, 1.42%; P = 0.69). This improvement seemed to be significant when the age-adjusted baseline FMD levels were <5.2% (5 trials; WMD: 2.22%; 95% CI: 1.15%, 3.30%; P < 0.0001), although significant heterogeneity was still detected in this low-baseline-FMD subgroup. CONCLUSIONS: Oral isoflavone supplementation does not improve endothelial function in postmenopausal women with high baseline FMD levels but leads to significant improvement in women with low baseline FMD levels. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/19923372/Effect_of_oral_isoflavone_supplementation_on_vascular_endothelial_function_in_postmenopausal_women:_a_meta_analysis_of_randomized_placebo_controlled_trials_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.2009.28203 DB - PRIME DP - Unbound Medicine ER -