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Dietary folate, vitamin B-12, vitamin B-6 and incident Alzheimer's disease: the cache county memory, health and aging study.
J Nutr Health Aging 2009; 13(10):899-905JN

Abstract

OBJECTIVE

To examine associations between dietary and supplemental folate, vitamin B-12 and vitamin B-6 and incident Alzheimer's disease (AD) among elderly men and women.

DESIGN, SETTING AND PARTICIPANTS

Data collected were from participants of the Cache County Memory, Health and Aging Study, a longitudinal study of 5092 men and women 65 years and older who were residents of Cache County, Utah in 1995.

MEASUREMENTS

Multistage clinical assessment procedures were used to identify incident cases of AD. Dietary data were collected using a 142-item food frequency questionnaire. Cox Proportional Hazards (CPH) modeling was used to determine hazard ratios across quintiles of micronutrient intake.

RESULTS

202 participants were diagnosed with incident AD during follow-up (1995-2004). In multivariable CPH models that controlled for the effects of gender, age, education, and other covariates there were no observed differences in risk of AD or dementia by increasing quintiles of total intake of folate, vitamin B-12, or vitamin B-6. Similarly, there were no observed differences in risk of AD by regular use of either folate or B6 supplements.

CONCLUSION

Dietary intake of B-vitamins from food and supplemental sources appears unrelated to incidence of dementia and AD. Further studies examining associations between dietary intakes of B-vitamins, biomarkers of B-vitamin status and cognitive endpoints are warranted.

Authors+Show Affiliations

Department of Nutrition and Food Sciences and Center for Epidemiologic Research, Utah State University, Logan, UT, 84322-8700, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19924351

Citation

Nelson, C, et al. "Dietary Folate, Vitamin B-12, Vitamin B-6 and Incident Alzheimer's Disease: the Cache County Memory, Health and Aging Study." The Journal of Nutrition, Health & Aging, vol. 13, no. 10, 2009, pp. 899-905.
Nelson C, Wengreen HJ, Munger RG, et al. Dietary folate, vitamin B-12, vitamin B-6 and incident Alzheimer's disease: the cache county memory, health and aging study. J Nutr Health Aging. 2009;13(10):899-905.
Nelson, C., Wengreen, H. J., Munger, R. G., & Corcoran, C. D. (2009). Dietary folate, vitamin B-12, vitamin B-6 and incident Alzheimer's disease: the cache county memory, health and aging study. The Journal of Nutrition, Health & Aging, 13(10), pp. 899-905.
Nelson C, et al. Dietary Folate, Vitamin B-12, Vitamin B-6 and Incident Alzheimer's Disease: the Cache County Memory, Health and Aging Study. J Nutr Health Aging. 2009;13(10):899-905. PubMed PMID: 19924351.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary folate, vitamin B-12, vitamin B-6 and incident Alzheimer's disease: the cache county memory, health and aging study. AU - Nelson,C, AU - Wengreen,H J, AU - Munger,R G, AU - Corcoran,C D, PY - 2009/11/20/entrez PY - 2009/11/20/pubmed PY - 2010/3/20/medline SP - 899 EP - 905 JF - The journal of nutrition, health & aging JO - J Nutr Health Aging VL - 13 IS - 10 N2 - OBJECTIVE: To examine associations between dietary and supplemental folate, vitamin B-12 and vitamin B-6 and incident Alzheimer's disease (AD) among elderly men and women. DESIGN, SETTING AND PARTICIPANTS: Data collected were from participants of the Cache County Memory, Health and Aging Study, a longitudinal study of 5092 men and women 65 years and older who were residents of Cache County, Utah in 1995. MEASUREMENTS: Multistage clinical assessment procedures were used to identify incident cases of AD. Dietary data were collected using a 142-item food frequency questionnaire. Cox Proportional Hazards (CPH) modeling was used to determine hazard ratios across quintiles of micronutrient intake. RESULTS: 202 participants were diagnosed with incident AD during follow-up (1995-2004). In multivariable CPH models that controlled for the effects of gender, age, education, and other covariates there were no observed differences in risk of AD or dementia by increasing quintiles of total intake of folate, vitamin B-12, or vitamin B-6. Similarly, there were no observed differences in risk of AD by regular use of either folate or B6 supplements. CONCLUSION: Dietary intake of B-vitamins from food and supplemental sources appears unrelated to incidence of dementia and AD. Further studies examining associations between dietary intakes of B-vitamins, biomarkers of B-vitamin status and cognitive endpoints are warranted. SN - 1760-4788 UR - https://www.unboundmedicine.com/medline/citation/19924351/Dietary_folate_vitamin_B_12_vitamin_B_6_and_incident_Alzheimer's_disease:_the_cache_county_memory_health_and_aging_study_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19924351/ DB - PRIME DP - Unbound Medicine ER -