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The potential clinical impact of probiotic treatment for the prevention and/or anti-inflammatory therapeutic effect against radiation induced intestinal mucositis. A review.

Abstract

Although pelvic radiotherapy, either alone or combined with chemotherapy, has proved to be successful in the treatment of patients with rectal, gynecological and urologic cancer, it is not devoid of side effects. Among patients receiving pelvic radiotherapy more than 70% develop acute inflammatory changes causing gastrointestinal symptoms during treatment. The most frequently reported symptom related to radiation-induced intestinal mucositis is diarrhea. Among nutritional interventions used to manage radiation-induced diarrhoea, probiotics has gained popularity. This term describes organisms and substances that improve microbial balance in the intestines. Although encouraging results have been obtained in clinical trials, the potential of oral probiotics to manage gastrointestinal symptoms needs further research. The article also outlines recent patents related to probiotics therapy to reduce radiation induced mocositis.

Authors+Show Affiliations

Radiotherapy Department, Attikon University Hospital, Medical School of Athens, Rimini 1 Haidari, 15341 Athens, Greece. vkouloul@cc.ece.ntua.gr.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19925445

Citation

Maria-Aggeliki, Kalogeridi S., et al. "The Potential Clinical Impact of Probiotic Treatment for the Prevention And/or Anti-inflammatory Therapeutic Effect Against Radiation Induced Intestinal Mucositis. a Review." Recent Patents On Inflammation & Allergy Drug Discovery, vol. 3, no. 3, 2009, pp. 195-200.
Maria-Aggeliki KS, Nikolaos KL, Kyrias GM, et al. The potential clinical impact of probiotic treatment for the prevention and/or anti-inflammatory therapeutic effect against radiation induced intestinal mucositis. A review. Recent Pat Inflamm Allergy Drug Discov. 2009;3(3):195-200.
Maria-Aggeliki, K. S., Nikolaos, K. L., Kyrias, G. M., & Vassilis, K. E. (2009). The potential clinical impact of probiotic treatment for the prevention and/or anti-inflammatory therapeutic effect against radiation induced intestinal mucositis. A review. Recent Patents On Inflammation & Allergy Drug Discovery, 3(3), pp. 195-200.
Maria-Aggeliki KS, et al. The Potential Clinical Impact of Probiotic Treatment for the Prevention And/or Anti-inflammatory Therapeutic Effect Against Radiation Induced Intestinal Mucositis. a Review. Recent Pat Inflamm Allergy Drug Discov. 2009;3(3):195-200. PubMed PMID: 19925445.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The potential clinical impact of probiotic treatment for the prevention and/or anti-inflammatory therapeutic effect against radiation induced intestinal mucositis. A review. AU - Maria-Aggeliki,Kalogeridi S, AU - Nikolaos,Kelekis L, AU - Kyrias,George M, AU - Vassilis,Kouloulias E, PY - 2009/11/21/entrez PY - 2009/11/21/pubmed PY - 2010/6/4/medline SP - 195 EP - 200 JF - Recent patents on inflammation & allergy drug discovery JO - Recent Pat Inflamm Allergy Drug Discov VL - 3 IS - 3 N2 - Although pelvic radiotherapy, either alone or combined with chemotherapy, has proved to be successful in the treatment of patients with rectal, gynecological and urologic cancer, it is not devoid of side effects. Among patients receiving pelvic radiotherapy more than 70% develop acute inflammatory changes causing gastrointestinal symptoms during treatment. The most frequently reported symptom related to radiation-induced intestinal mucositis is diarrhea. Among nutritional interventions used to manage radiation-induced diarrhoea, probiotics has gained popularity. This term describes organisms and substances that improve microbial balance in the intestines. Although encouraging results have been obtained in clinical trials, the potential of oral probiotics to manage gastrointestinal symptoms needs further research. The article also outlines recent patents related to probiotics therapy to reduce radiation induced mocositis. SN - 1872-213X UR - https://www.unboundmedicine.com/medline/citation/19925445/The_potential_clinical_impact_of_probiotic_treatment_for_the_prevention_and/or_anti_inflammatory_therapeutic_effect_against_radiation_induced_intestinal_mucositis__A_review_ L2 - http://www.eurekaselect.com/93502/article DB - PRIME DP - Unbound Medicine ER -