Tags

Type your tag names separated by a space and hit enter

Sustained virological response to pegylated interferon and ribavirin is maintained during long-term follow-up of chronic hepatitis C patients.
Aliment Pharmacol Ther 2010; 31(4):502-8AP

Abstract

BACKGROUND

There are few data in the literature regarding the long-term virological follow-up of chronic hepatitis C patients who obtain sustained virological response (SVR) to pegylated interferon (PEG-IFN) and ribavirin therapy.

AIM

To assess the durability of SVR to PEG-IFN and ribavirin therapy during long-term follow-up of chronic hepatitis C patients.

METHODS

We evaluated a cohort of 231 chronic hepatitis C patients who had at least 48 weeks of follow-up after SVR to PEG-IFN and ribavirin treatment. Median duration of follow-up after SVR was 164 weeks, and exceeded 5 years in 30% of the cohort. Patients underwent consistent clinical, biochemical and virological evaluations every 6 months during follow-up.

RESULTS

Sustained virological response was maintained in 211 patients (91%) while HCV-RNA became positive in two patients (<1%) within 1 year after SVR, and in 18 patients (8%) serum HCV-RNA was transiently positive in at least one follow-up evaluation. Clinical outcome was not significantly different between patients with persistently negative and transiently positive serum HCV-RNA.

CONCLUSIONS

Sustained virological response to PEG-IFN and ribavirin is maintained in 99% of patients during long-term follow-up. Late virological relapse occurred within 1 year after SVR and, from a clinical perspective, patients can be considered cured of infection after this period.

Authors+Show Affiliations

Gastroenterology Unit, Department of Internal Medicine, University of Genoa, Genoa, Italy. egiannini@unige.itNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19925499

Citation

Giannini, E G., et al. "Sustained Virological Response to Pegylated Interferon and Ribavirin Is Maintained During Long-term Follow-up of Chronic Hepatitis C Patients." Alimentary Pharmacology & Therapeutics, vol. 31, no. 4, 2010, pp. 502-8.
Giannini EG, Basso M, Savarino V, et al. Sustained virological response to pegylated interferon and ribavirin is maintained during long-term follow-up of chronic hepatitis C patients. Aliment Pharmacol Ther. 2010;31(4):502-8.
Giannini, E. G., Basso, M., Savarino, V., & Picciotto, A. (2010). Sustained virological response to pegylated interferon and ribavirin is maintained during long-term follow-up of chronic hepatitis C patients. Alimentary Pharmacology & Therapeutics, 31(4), pp. 502-8. doi:10.1111/j.1365-2036.2009.04201.x.
Giannini EG, et al. Sustained Virological Response to Pegylated Interferon and Ribavirin Is Maintained During Long-term Follow-up of Chronic Hepatitis C Patients. Aliment Pharmacol Ther. 2010 Feb 15;31(4):502-8. PubMed PMID: 19925499.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sustained virological response to pegylated interferon and ribavirin is maintained during long-term follow-up of chronic hepatitis C patients. AU - Giannini,E G, AU - Basso,M, AU - Savarino,V, AU - Picciotto,A, Y1 - 2009/11/19/ PY - 2009/11/21/entrez PY - 2009/11/21/pubmed PY - 2010/6/30/medline SP - 502 EP - 8 JF - Alimentary pharmacology & therapeutics JO - Aliment. Pharmacol. Ther. VL - 31 IS - 4 N2 - BACKGROUND: There are few data in the literature regarding the long-term virological follow-up of chronic hepatitis C patients who obtain sustained virological response (SVR) to pegylated interferon (PEG-IFN) and ribavirin therapy. AIM: To assess the durability of SVR to PEG-IFN and ribavirin therapy during long-term follow-up of chronic hepatitis C patients. METHODS: We evaluated a cohort of 231 chronic hepatitis C patients who had at least 48 weeks of follow-up after SVR to PEG-IFN and ribavirin treatment. Median duration of follow-up after SVR was 164 weeks, and exceeded 5 years in 30% of the cohort. Patients underwent consistent clinical, biochemical and virological evaluations every 6 months during follow-up. RESULTS: Sustained virological response was maintained in 211 patients (91%) while HCV-RNA became positive in two patients (<1%) within 1 year after SVR, and in 18 patients (8%) serum HCV-RNA was transiently positive in at least one follow-up evaluation. Clinical outcome was not significantly different between patients with persistently negative and transiently positive serum HCV-RNA. CONCLUSIONS: Sustained virological response to PEG-IFN and ribavirin is maintained in 99% of patients during long-term follow-up. Late virological relapse occurred within 1 year after SVR and, from a clinical perspective, patients can be considered cured of infection after this period. SN - 1365-2036 UR - https://www.unboundmedicine.com/medline/citation/19925499/Sustained_virological_response_to_pegylated_interferon_and_ribavirin_is_maintained_during_long_term_follow_up_of_chronic_hepatitis_C_patients_ L2 - https://doi.org/10.1111/j.1365-2036.2009.04201.x DB - PRIME DP - Unbound Medicine ER -