Tags

Type your tag names separated by a space and hit enter

Acute generalized exanthematous pustulosis (AGEP) induced by cefotaxime.
Fundam Clin Pharmacol. 2010 Aug; 24(4):429-32.FC

Abstract

We report a case of acute generalized exanthematous pustulosis (AGEP) after cefotaxime use confirmed by a positive patch test. A 30-year-old woman received cefotaxime, fosfomycin and ciprofloxacin for sinusitis. Twelve days after drug initiation, she developed an extending pustular erythema associated with fever. Laboratory investigations showed marked leukocytosis. His blood chemistry was normal. The histological examination showed parakeratosis, spongiosis and nonfollicular intra-epidermal pustules consistent with AGEP. All medications were withdrawn. The symptoms resolved within 11 days after cefotaxime discontinuation. Patch tests were positive to cefotaxime after 48 h, while ciprofloxacin and fosfomycin yielded negative findings. Based on the Naranjo algorithm, it is probable that AGEP reaction was caused by cefotaxime. To our knowledge, this is the first reported case of AGEP associated with positive cefotaxime patch testing.

Links

Aggregator Full Text

Authors+Show Affiliations

Chaabane A
Pharmacology Departement, Medicine University, Monastir, Tunisia. chaabane_amel@yahoo.fr
Aouam K
No affiliation info available
Gassab L
No affiliation info available
Njim L
No affiliation info available
Boughattas NA
No affiliation info available

MeSH

Acute Generalized Exanthematous PustulosisAdultAnti-Bacterial AgentsCefotaximeDrug EruptionsFemaleHumansPatch TestsSinusitis

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

19925632

Citation

Chaabane, Amel, et al. "Acute Generalized Exanthematous Pustulosis (AGEP) Induced By Cefotaxime." Fundamental & Clinical Pharmacology, vol. 24, no. 4, 2010, pp. 429-32.
Chaabane A, Aouam K, Gassab L, et al. Acute generalized exanthematous pustulosis (AGEP) induced by cefotaxime. Fundam Clin Pharmacol. 2010;24(4):429-32.
Chaabane, A., Aouam, K., Gassab, L., Njim, L., & Boughattas, N. A. (2010). Acute generalized exanthematous pustulosis (AGEP) induced by cefotaxime. Fundamental & Clinical Pharmacology, 24(4), 429-32. https://doi.org/10.1111/j.1472-8206.2009.00794.x
Chaabane A, et al. Acute Generalized Exanthematous Pustulosis (AGEP) Induced By Cefotaxime. Fundam Clin Pharmacol. 2010;24(4):429-32. PubMed PMID: 19925632.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute generalized exanthematous pustulosis (AGEP) induced by cefotaxime. AU - Chaabane,Amel, AU - Aouam,Karim, AU - Gassab,Lies, AU - Njim,Leila, AU - Boughattas,Naceur A, Y1 - 2009/11/18/ PY - 2009/11/21/entrez PY - 2009/11/21/pubmed PY - 2010/12/14/medline SP - 429 EP - 32 JF - Fundamental & clinical pharmacology JO - Fundam Clin Pharmacol VL - 24 IS - 4 N2 - We report a case of acute generalized exanthematous pustulosis (AGEP) after cefotaxime use confirmed by a positive patch test. A 30-year-old woman received cefotaxime, fosfomycin and ciprofloxacin for sinusitis. Twelve days after drug initiation, she developed an extending pustular erythema associated with fever. Laboratory investigations showed marked leukocytosis. His blood chemistry was normal. The histological examination showed parakeratosis, spongiosis and nonfollicular intra-epidermal pustules consistent with AGEP. All medications were withdrawn. The symptoms resolved within 11 days after cefotaxime discontinuation. Patch tests were positive to cefotaxime after 48 h, while ciprofloxacin and fosfomycin yielded negative findings. Based on the Naranjo algorithm, it is probable that AGEP reaction was caused by cefotaxime. To our knowledge, this is the first reported case of AGEP associated with positive cefotaxime patch testing. SN - 1472-8206 UR - https://www.unboundmedicine.com/medline/citation/19925632/Acute_generalized_exanthematous_pustulosis__AGEP__induced_by_cefotaxime_ L2 - https://doi.org/10.1111/j.1472-8206.2009.00794.x DB - PRIME DP - Unbound Medicine ER -