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Maternal Lyme borreliosis and pregnancy outcome.

Abstract

BACKGROUND

There is disagreement regarding whether Lyme borreliosis is associated with adverse pregnancy outcome.

METHODS

We performed a review of the data from 95 women with Lyme borreliosis during pregnancy, evaluated at the Center for Tick-borne Diseases, Budapest over the past 22 years.

RESULTS

Treatment was administered parenterally to 66 (69.5%) women and orally to 19 (20%). Infection remained untreated in 10 (10.5%) pregnancies. Adverse outcomes were seen in 8/66 (12.1%) parentally treated women, 6/19 (31.6%) orally treated women, and 6/10 (60%) untreated women. In comparison to patients treated with antibiotics, untreated women had a significantly higher risk of adverse pregnancy outcome (odds ratio (OR) 7.61, p=0.004). While mothers treated orally had an increased chance (OR 3.35) of having an adverse outcome compared to those treated parenterally, this difference was not statistically significant (p=0.052). Erythema migrans did not resolve by the end of the first antibiotic course in 17 patients. Adverse pregnancy outcome was more frequent among these 'slow responder' mothers (OR 2.69), but this was not statistically significant (p=0.1425) . Loss of the pregnancy (n=7) and cavernous hemangioma (n=4) were the most prevalent adverse outcomes in our series. The other complications were heterogeneous.

CONCLUSION

Our results indicate that an untreated maternal Borrelia burgdorferi s.l. infection may be associated with an adverse outcome, although bacterial invasion of the fetus cannot be proven. It appears that a specific syndrome representing 'congenital Lyme borreliosis' is unlikely.

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  • Authors+Show Affiliations

    ,

    The Center for Tick-borne Diseases, Visegrádi 14, Budapest, H-1132, Hungary. alakos@t-online.hu

    Source

    MeSH

    Administration, Oral
    Anti-Bacterial Agents
    Borrelia burgdorferi
    Female
    Humans
    Hungary
    Incidence
    Injections
    Lyme Disease
    Pregnancy
    Pregnancy Complications, Infectious
    Pregnancy Outcome

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    19926325

    Citation

    TY - JOUR T1 - Maternal Lyme borreliosis and pregnancy outcome. AU - Lakos,András, AU - Solymosi,Norbert, Y1 - 2009/11/18/ PY - 2009/4/10/received PY - 2009/5/29/revised PY - 2009/7/23/accepted PY - 2009/11/18/aheadofprint PY - 2009/11/21/entrez PY - 2009/11/21/pubmed PY - 2010/9/10/medline SP - e494 EP - 8 JF - International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases JO - Int. J. Infect. Dis. VL - 14 IS - 6 N2 - BACKGROUND: There is disagreement regarding whether Lyme borreliosis is associated with adverse pregnancy outcome. METHODS: We performed a review of the data from 95 women with Lyme borreliosis during pregnancy, evaluated at the Center for Tick-borne Diseases, Budapest over the past 22 years. RESULTS: Treatment was administered parenterally to 66 (69.5%) women and orally to 19 (20%). Infection remained untreated in 10 (10.5%) pregnancies. Adverse outcomes were seen in 8/66 (12.1%) parentally treated women, 6/19 (31.6%) orally treated women, and 6/10 (60%) untreated women. In comparison to patients treated with antibiotics, untreated women had a significantly higher risk of adverse pregnancy outcome (odds ratio (OR) 7.61, p=0.004). While mothers treated orally had an increased chance (OR 3.35) of having an adverse outcome compared to those treated parenterally, this difference was not statistically significant (p=0.052). Erythema migrans did not resolve by the end of the first antibiotic course in 17 patients. Adverse pregnancy outcome was more frequent among these 'slow responder' mothers (OR 2.69), but this was not statistically significant (p=0.1425) . Loss of the pregnancy (n=7) and cavernous hemangioma (n=4) were the most prevalent adverse outcomes in our series. The other complications were heterogeneous. CONCLUSION: Our results indicate that an untreated maternal Borrelia burgdorferi s.l. infection may be associated with an adverse outcome, although bacterial invasion of the fetus cannot be proven. It appears that a specific syndrome representing 'congenital Lyme borreliosis' is unlikely. SN - 1878-3511 UR - https://www.unboundmedicine.com/medline/citation/19926325/abstract/Maternal_Lyme_borreliosis_and_pregnancy_outcome_ L2 - http://linkinghub.elsevier.com/retrieve/pii/S1201-9712(09)00331-2 ER -