Tags

Type your tag names separated by a space and hit enter

Hypertension and dementia.
Am J Hypertens. 2010 Feb; 23(2):116-24.AJ

Abstract

Although hypertension is well known as a cause of vascular dementia (VaD), recent findings highlight the role of hypertension in the pathogenesis of Alzheimer's disease (AD) as well as mild cognitive impairment (MCI). Recent studies have shown that disruption of diurnal blood pressure (BP) variation is closely associated with cognitive impairment via injury of the small cerebral arteries indicating that long-standing hypertension constitutes a risk of brain matter atrophy or white matter lesions (WMLs). In several clinical trials, BP-lowering with antihypertensive agents was suggested to reduce the risk of dementia or cognitive decline. This review paper focuses on the role of hypertension as a risk factor for cognitive impairment, and summarizes current knowledge on the relationships between ambulatory BP monitoring (ABPM) and cognitive impairment. Finally, an overview of the impact of antihypertensive therapy on dementia prevention is provided.

Authors+Show Affiliations

Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

19927134

Citation

Nagai, Michiaki, et al. "Hypertension and Dementia." American Journal of Hypertension, vol. 23, no. 2, 2010, pp. 116-24.
Nagai M, Hoshide S, Kario K. Hypertension and dementia. Am J Hypertens. 2010;23(2):116-24.
Nagai, M., Hoshide, S., & Kario, K. (2010). Hypertension and dementia. American Journal of Hypertension, 23(2), 116-24. https://doi.org/10.1038/ajh.2009.212
Nagai M, Hoshide S, Kario K. Hypertension and Dementia. Am J Hypertens. 2010;23(2):116-24. PubMed PMID: 19927134.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hypertension and dementia. AU - Nagai,Michiaki, AU - Hoshide,Satoshi, AU - Kario,Kazuomi, Y1 - 2009/11/19/ PY - 2009/11/21/entrez PY - 2009/11/21/pubmed PY - 2010/3/10/medline SP - 116 EP - 24 JF - American journal of hypertension JO - Am. J. Hypertens. VL - 23 IS - 2 N2 - Although hypertension is well known as a cause of vascular dementia (VaD), recent findings highlight the role of hypertension in the pathogenesis of Alzheimer's disease (AD) as well as mild cognitive impairment (MCI). Recent studies have shown that disruption of diurnal blood pressure (BP) variation is closely associated with cognitive impairment via injury of the small cerebral arteries indicating that long-standing hypertension constitutes a risk of brain matter atrophy or white matter lesions (WMLs). In several clinical trials, BP-lowering with antihypertensive agents was suggested to reduce the risk of dementia or cognitive decline. This review paper focuses on the role of hypertension as a risk factor for cognitive impairment, and summarizes current knowledge on the relationships between ambulatory BP monitoring (ABPM) and cognitive impairment. Finally, an overview of the impact of antihypertensive therapy on dementia prevention is provided. SN - 1941-7225 UR - https://www.unboundmedicine.com/medline/citation/19927134/Hypertension_and_dementia_ L2 - https://academic.oup.com/ajh/article-lookup/doi/10.1038/ajh.2009.212 DB - PRIME DP - Unbound Medicine ER -