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Decreased adiponectin levels in polycystic ovary syndrome, independent of body mass index.
Metab Syndr Relat Disord. 2010 Feb; 8(1):47-52.MS

Abstract

BACKGROUND

Insulin resistance has been shown to have an association with polycystic ovary syndrome (PCOS). This study was designed to evaluate the potential role of adiponectin, which is linked with insulin resistance, in the etiology of PCOS and its relationship to obesity.

METHODS

This case-control study consisted of 103 newly diagnosed PCOS cases and 73 female controls seen at a referral university hospital in Zanjan, Iran. Serum adiponectin, insulin, plasma fasting glucose, and lipid levels were measured. The homeostasis model assessment index was used to determine the level of insulin resistance. Women were classified as follows: Group I (normal nonlean women); group II (normal lean women); group III (nonlean women with PCOS); and group IV (lean women with PCOS) RESULTS: Adiponectin levels were decreased in women with PCOS (8.4 +/- 2.7 ng/mL vs. 13.6 +/- 5 ng/mL in the control group, P < 0.001). There was no significant difference between the adiponectin concentrations of women in group III and that in group IV (8.1 +/- 2.8 ng/mL vs. 9.2 +/- 2.6 ng/mL, respectively, P = 0.1). Adiponectin levels were significantly lower in group I compared with group II. A weak but significant negative correlation was found between adiponectin and insulin levels in all the subjects. Multiple regression analyses showed that the presence of PCOS was the only significant determinant of serum adiponectin levels.

CONCLUSIONS

Adiponectin levels were reduced in all the women with PCOS. There seemed to be an interaction between adiponectin and PCOS pathogenesis that was independent of body mass index.

Authors+Show Affiliations

Department of Clinical Endocrinology, Zanjan Metabolic Diseases Research Center, Vali-e Asr Hospital, Zanjan, Iran. faranaksharifi @hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19929617

Citation

Sharifi, Faranak, et al. "Decreased Adiponectin Levels in Polycystic Ovary Syndrome, Independent of Body Mass Index." Metabolic Syndrome and Related Disorders, vol. 8, no. 1, 2010, pp. 47-52.
Sharifi F, Hajihosseini R, Mazloomi S, et al. Decreased adiponectin levels in polycystic ovary syndrome, independent of body mass index. Metab Syndr Relat Disord. 2010;8(1):47-52.
Sharifi, F., Hajihosseini, R., Mazloomi, S., Amirmogaddami, H., & Nazem, H. (2010). Decreased adiponectin levels in polycystic ovary syndrome, independent of body mass index. Metabolic Syndrome and Related Disorders, 8(1), 47-52. https://doi.org/10.1089/met.2009.0036
Sharifi F, et al. Decreased Adiponectin Levels in Polycystic Ovary Syndrome, Independent of Body Mass Index. Metab Syndr Relat Disord. 2010;8(1):47-52. PubMed PMID: 19929617.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Decreased adiponectin levels in polycystic ovary syndrome, independent of body mass index. AU - Sharifi,Faranak, AU - Hajihosseini,Reza, AU - Mazloomi,Sahar, AU - Amirmogaddami,Hamidreza, AU - Nazem,Habibollah, PY - 2009/11/26/entrez PY - 2009/11/26/pubmed PY - 2010/5/26/medline SP - 47 EP - 52 JF - Metabolic syndrome and related disorders JO - Metab Syndr Relat Disord VL - 8 IS - 1 N2 - BACKGROUND: Insulin resistance has been shown to have an association with polycystic ovary syndrome (PCOS). This study was designed to evaluate the potential role of adiponectin, which is linked with insulin resistance, in the etiology of PCOS and its relationship to obesity. METHODS: This case-control study consisted of 103 newly diagnosed PCOS cases and 73 female controls seen at a referral university hospital in Zanjan, Iran. Serum adiponectin, insulin, plasma fasting glucose, and lipid levels were measured. The homeostasis model assessment index was used to determine the level of insulin resistance. Women were classified as follows: Group I (normal nonlean women); group II (normal lean women); group III (nonlean women with PCOS); and group IV (lean women with PCOS) RESULTS: Adiponectin levels were decreased in women with PCOS (8.4 +/- 2.7 ng/mL vs. 13.6 +/- 5 ng/mL in the control group, P < 0.001). There was no significant difference between the adiponectin concentrations of women in group III and that in group IV (8.1 +/- 2.8 ng/mL vs. 9.2 +/- 2.6 ng/mL, respectively, P = 0.1). Adiponectin levels were significantly lower in group I compared with group II. A weak but significant negative correlation was found between adiponectin and insulin levels in all the subjects. Multiple regression analyses showed that the presence of PCOS was the only significant determinant of serum adiponectin levels. CONCLUSIONS: Adiponectin levels were reduced in all the women with PCOS. There seemed to be an interaction between adiponectin and PCOS pathogenesis that was independent of body mass index. SN - 1557-8518 UR - https://www.unboundmedicine.com/medline/citation/19929617/Decreased_adiponectin_levels_in_polycystic_ovary_syndrome_independent_of_body_mass_index_ L2 - https://www.liebertpub.com/doi/10.1089/met.2009.0036?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -