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Effect of dietary fish oil on plasma thromboxane B2 and 6-keto-prostaglandin F1 alpha levels in septic rats.
Arch Surg. 1991 Feb; 126(2):179-82.AS

Abstract

Increased mortality from sepsis is associated with high levels of thromboxane B2 (TXB2) and 6-keto-prostaglandin F1 alpha (PGF1 alpha). Linoleic acid, an n-6 essential fatty acid, is the usual precursor of TXB2 and PGF1 alpha, while fish oil is rich in n-3 essential fatty acid, the precursor of less active moieties. Rats were fed chow, an essential fatty acid-deficient diet, or an essential fatty acid-deficient diet supplemented with linoleic acid or fish oil for 2 weeks. The animals then underwent a sham operation or cecal ligation and puncture to induce sepsis. Six hours later, blood was obtained for analysis. The chow and linoleic acid diets produced significant (twofold to fivefold) increases in levels of both TXB2 and PGF1 alpha after sepsis. The essential fatty acid-deficient diet and fish oil diet protected against increases in levels of TXB2 or PGF1 alpha during sepsis. Dietary restriction of linoleic acid or fish oil supplementation may play an important role in altering the inflammatory mediator response to sepsis.

Authors+Show Affiliations

Department of Surgery, University of North Carolina, Chapel Hill.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1992995

Citation

Muakkassa, F F., et al. "Effect of Dietary Fish Oil On Plasma Thromboxane B2 and 6-keto-prostaglandin F1 Alpha Levels in Septic Rats." Archives of Surgery (Chicago, Ill. : 1960), vol. 126, no. 2, 1991, pp. 179-82.
Muakkassa FF, Koruda MJ, Ramadan FM, et al. Effect of dietary fish oil on plasma thromboxane B2 and 6-keto-prostaglandin F1 alpha levels in septic rats. Arch Surg. 1991;126(2):179-82.
Muakkassa, F. F., Koruda, M. J., Ramadan, F. M., Kawakami, M., & Meyer, A. A. (1991). Effect of dietary fish oil on plasma thromboxane B2 and 6-keto-prostaglandin F1 alpha levels in septic rats. Archives of Surgery (Chicago, Ill. : 1960), 126(2), 179-82.
Muakkassa FF, et al. Effect of Dietary Fish Oil On Plasma Thromboxane B2 and 6-keto-prostaglandin F1 Alpha Levels in Septic Rats. Arch Surg. 1991;126(2):179-82. PubMed PMID: 1992995.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of dietary fish oil on plasma thromboxane B2 and 6-keto-prostaglandin F1 alpha levels in septic rats. AU - Muakkassa,F F, AU - Koruda,M J, AU - Ramadan,F M, AU - Kawakami,M, AU - Meyer,A A, PY - 1991/2/1/pubmed PY - 1991/2/1/medline PY - 1991/2/1/entrez SP - 179 EP - 82 JF - Archives of surgery (Chicago, Ill. : 1960) JO - Arch Surg VL - 126 IS - 2 N2 - Increased mortality from sepsis is associated with high levels of thromboxane B2 (TXB2) and 6-keto-prostaglandin F1 alpha (PGF1 alpha). Linoleic acid, an n-6 essential fatty acid, is the usual precursor of TXB2 and PGF1 alpha, while fish oil is rich in n-3 essential fatty acid, the precursor of less active moieties. Rats were fed chow, an essential fatty acid-deficient diet, or an essential fatty acid-deficient diet supplemented with linoleic acid or fish oil for 2 weeks. The animals then underwent a sham operation or cecal ligation and puncture to induce sepsis. Six hours later, blood was obtained for analysis. The chow and linoleic acid diets produced significant (twofold to fivefold) increases in levels of both TXB2 and PGF1 alpha after sepsis. The essential fatty acid-deficient diet and fish oil diet protected against increases in levels of TXB2 or PGF1 alpha during sepsis. Dietary restriction of linoleic acid or fish oil supplementation may play an important role in altering the inflammatory mediator response to sepsis. SN - 0004-0010 UR - https://www.unboundmedicine.com/medline/citation/1992995/Effect_of_dietary_fish_oil_on_plasma_thromboxane_B2_and_6_keto_prostaglandin_F1_alpha_levels_in_septic_rats_ L2 - https://jamanetwork.com/journals/jamasurgery/fullarticle/vol/126/pg/179 DB - PRIME DP - Unbound Medicine ER -