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Baselines representing blood glucose clearance improve in vitro prediction of the glycaemic impact of customarily consumed food quantities.
Br J Nutr. 2010 Jan; 103(2):295-305.BJ

Abstract

Glycaemic responses to foods reflect the balance between glucose loading into, and its clearance from, the blood. Current in vitro methods for glycaemic analysis do not take into account the key role of glucose disposal. The present study aimed to develop a food intake-sensitive method for measuring the glycaemic impact of food quantities usually consumed, as the difference between release of glucose equivalents (GGE) from food during in vitro digestion and a corresponding estimate of clearance of them from the blood. Five foods - white bread, fruit bread, muesli bar, mashed potato and chickpeas - were consumed on three occasions by twenty volunteers to provide blood glucose response (BGR) curves. GGE release during in vitro digestion of the foods was also plotted. Glucose disposal rates estimated from downward slopes of the BGR curves allowed GGE dose-dependent cumulative glucose disposal to be calculated. By subtracting cumulative glucose disposal from cumulative in vitro GGE release, accuracy in predicting the in vivo glycaemic effect from in vitro GGE values was greatly improved. GGE(in vivo) = 0.99GGE(in vitro)+0.75 (R(2) 0.88). Furthermore, the difference between the curves of cumulative GGE release and disposal closely mimicked in vivo incremental BGR curves. We conclude that valid measurement of the glycaemic impact of foods may be obtained in vitro, and expressed as grams of glucose equivalents per food quantity, by taking account not only of GGE release from food during in vitro digestion, but also of blood glucose clearance in response to the food quantity.

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Authors+Show Affiliations

Monro JA
New Zealand Institute for Plant and Food Research Ltd, Private Bag 11 600, Palmerston North, New Zealand.
Mishra S
No affiliation info available
Venn B
No affiliation info available

MeSH

Blood GlucoseCookingDietary CarbohydratesDigestionFood AnalysisGlycemic IndexHumansMetabolic Clearance RateNew ZealandPredictive Value of Tests

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19930760

Citation

Monro, John A., et al. "Baselines Representing Blood Glucose Clearance Improve in Vitro Prediction of the Glycaemic Impact of Customarily Consumed Food Quantities." The British Journal of Nutrition, vol. 103, no. 2, 2010, pp. 295-305.
Monro JA, Mishra S, Venn B. Baselines representing blood glucose clearance improve in vitro prediction of the glycaemic impact of customarily consumed food quantities. Br J Nutr. 2010;103(2):295-305.
Monro, J. A., Mishra, S., & Venn, B. (2010). Baselines representing blood glucose clearance improve in vitro prediction of the glycaemic impact of customarily consumed food quantities. The British Journal of Nutrition, 103(2), 295-305. https://doi.org/10.1017/S0007114509991632
Monro JA, Mishra S, Venn B. Baselines Representing Blood Glucose Clearance Improve in Vitro Prediction of the Glycaemic Impact of Customarily Consumed Food Quantities. Br J Nutr. 2010;103(2):295-305. PubMed PMID: 19930760.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Baselines representing blood glucose clearance improve in vitro prediction of the glycaemic impact of customarily consumed food quantities. AU - Monro,John A, AU - Mishra,Suman, AU - Venn,Bernard, Y1 - 2009/11/24/ PY - 2009/11/26/entrez PY - 2009/11/26/pubmed PY - 2010/2/2/medline SP - 295 EP - 305 JF - The British journal of nutrition JO - Br J Nutr VL - 103 IS - 2 N2 - Glycaemic responses to foods reflect the balance between glucose loading into, and its clearance from, the blood. Current in vitro methods for glycaemic analysis do not take into account the key role of glucose disposal. The present study aimed to develop a food intake-sensitive method for measuring the glycaemic impact of food quantities usually consumed, as the difference between release of glucose equivalents (GGE) from food during in vitro digestion and a corresponding estimate of clearance of them from the blood. Five foods - white bread, fruit bread, muesli bar, mashed potato and chickpeas - were consumed on three occasions by twenty volunteers to provide blood glucose response (BGR) curves. GGE release during in vitro digestion of the foods was also plotted. Glucose disposal rates estimated from downward slopes of the BGR curves allowed GGE dose-dependent cumulative glucose disposal to be calculated. By subtracting cumulative glucose disposal from cumulative in vitro GGE release, accuracy in predicting the in vivo glycaemic effect from in vitro GGE values was greatly improved. GGE(in vivo) = 0.99GGE(in vitro)+0.75 (R(2) 0.88). Furthermore, the difference between the curves of cumulative GGE release and disposal closely mimicked in vivo incremental BGR curves. We conclude that valid measurement of the glycaemic impact of foods may be obtained in vitro, and expressed as grams of glucose equivalents per food quantity, by taking account not only of GGE release from food during in vitro digestion, but also of blood glucose clearance in response to the food quantity. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/19930760/Baselines_representing_blood_glucose_clearance_improve_in_vitro_prediction_of_the_glycaemic_impact_of_customarily_consumed_food_quantities_ L2 - https://www.cambridge.org/core/product/identifier/S0007114509991632/type/journal_article DB - PRIME DP - Unbound Medicine ER -