Tags

Type your tag names separated by a space and hit enter

Antioxidant enzyme activity and lipid peroxidation in liver and gill tissues of Nile tilapia (Oreochromis niloticus) following in vivo exposure to domoic acid.
Toxicon. 2010 Apr 01; 55(4):734-8.T

Abstract

Domoic acid (DA) is a neurotoxicant produced by Pseudo-nitzschia from diatomeae. Although the neurotoxic and genotoxic effects of DA have been well documented, the number of in vivo studies regarding the oxidative stress inducing effects of DA is quite limited. In this study, in vivo toxic effects of DA were investigated on fish Oreochromis niloticus (Fam: Cichlidae), using oxidative stress biomarkers. Fish were exposed to three different concentrations (1, 5 and 10 microg/g body weight) of DA via intraperitoneal injections and the tissues were sampled at 24, 48 and 72 h post-treatment. Changes in the level of lipid peroxidation, and activities of antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GRd) were evaluated in liver and gill tissues. Our results revealed dose and time dependent increases in the oxidative stress parameters. It was also observed that the toxic effects were more pronounced in liver than in gill tissue.

Authors+Show Affiliations

Department of Biology, Faculty of Sciences and Letters, Mersin University, 33343, Ciftlikköy, 33343 Mersin, Turkey. bmazmanci@mersin.edu.trNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19931299

Citation

Mazmanci, Birgül, and Tolga Cavaş. "Antioxidant Enzyme Activity and Lipid Peroxidation in Liver and Gill Tissues of Nile Tilapia (Oreochromis Niloticus) Following in Vivo Exposure to Domoic Acid." Toxicon : Official Journal of the International Society On Toxinology, vol. 55, no. 4, 2010, pp. 734-8.
Mazmanci B, Cavaş T. Antioxidant enzyme activity and lipid peroxidation in liver and gill tissues of Nile tilapia (Oreochromis niloticus) following in vivo exposure to domoic acid. Toxicon. 2010;55(4):734-8.
Mazmanci, B., & Cavaş, T. (2010). Antioxidant enzyme activity and lipid peroxidation in liver and gill tissues of Nile tilapia (Oreochromis niloticus) following in vivo exposure to domoic acid. Toxicon : Official Journal of the International Society On Toxinology, 55(4), 734-8. https://doi.org/10.1016/j.toxicon.2009.11.003
Mazmanci B, Cavaş T. Antioxidant Enzyme Activity and Lipid Peroxidation in Liver and Gill Tissues of Nile Tilapia (Oreochromis Niloticus) Following in Vivo Exposure to Domoic Acid. Toxicon. 2010 Apr 1;55(4):734-8. PubMed PMID: 19931299.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant enzyme activity and lipid peroxidation in liver and gill tissues of Nile tilapia (Oreochromis niloticus) following in vivo exposure to domoic acid. AU - Mazmanci,Birgül, AU - Cavaş,Tolga, Y1 - 2009/11/18/ PY - 2009/09/11/received PY - 2009/10/26/revised PY - 2009/11/10/accepted PY - 2009/11/26/entrez PY - 2009/11/26/pubmed PY - 2010/6/15/medline SP - 734 EP - 8 JF - Toxicon : official journal of the International Society on Toxinology JO - Toxicon VL - 55 IS - 4 N2 - Domoic acid (DA) is a neurotoxicant produced by Pseudo-nitzschia from diatomeae. Although the neurotoxic and genotoxic effects of DA have been well documented, the number of in vivo studies regarding the oxidative stress inducing effects of DA is quite limited. In this study, in vivo toxic effects of DA were investigated on fish Oreochromis niloticus (Fam: Cichlidae), using oxidative stress biomarkers. Fish were exposed to three different concentrations (1, 5 and 10 microg/g body weight) of DA via intraperitoneal injections and the tissues were sampled at 24, 48 and 72 h post-treatment. Changes in the level of lipid peroxidation, and activities of antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GRd) were evaluated in liver and gill tissues. Our results revealed dose and time dependent increases in the oxidative stress parameters. It was also observed that the toxic effects were more pronounced in liver than in gill tissue. SN - 1879-3150 UR - https://www.unboundmedicine.com/medline/citation/19931299/Antioxidant_enzyme_activity_and_lipid_peroxidation_in_liver_and_gill_tissues_of_Nile_tilapia__Oreochromis_niloticus__following_in_vivo_exposure_to_domoic_acid_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0041-0101(09)00521-2 DB - PRIME DP - Unbound Medicine ER -