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The first results demonstrating efficiency and safety of a double-column whole blood method of LDL-apheresis.
Transfus Apher Sci. 2010 Feb; 42(1):3-10.TA

Abstract

LDL-apheresis is a treatment for familial hypercholesterolemia in addition to diet and drug therapy. In the past, LDL-apheresis techniques consisted in separating plasma from blood and adsorbing plasma LDL-C whereas recent methods remove LDL-C directly from whole blood. The whole blood system developed by Kaneka consists of a single-column (Liposorber DL-75) treatment (SCWB) but a double-column whole blood (DCWB) method has recently been developed (Liposorber DL-50 x 2). When 1.6 blood volumes (plus 1l) were processed, acute reductions of total cholesterol and LDL-C were 67.9+/-6% and 80.2+/-4.5%, respectively. The performances of the DCWB method were compared to other LDL-apheresis methods. Assessed in 10 patients, the DCWB method is more efficient than the SCWB method with higher reduction rates of LDL-C (79.7+/-4.9 vs. 68.2+/-5.0% p<0.0001) and apolipoprotein-B (79.5+/-5.4 vs. 67.4+/-5.4% p<0.0001). In a sub group of five patients having the highest LDL-C baseline levels, the LDL-C reduction rates obtained by the DCWB method are equivalent to those obtained by the conventional LDL-apheresis method consisting of preliminary plasma separation followed by plasma LDL-C adsorption and used as first line apheresis therapy (80.5+/-4.5 vs. 79.0+/-5.9%). The safety of DCWB was demonstrated in 12 patients with only a low frequency of mild and transient adverse effects (4%). In conclusion, the DCWB LDL-apheresis method provides efficient removal of LDL-C, a low level of adverse effects, and a shortened duration of the procedure.

Authors+Show Affiliations

Apheresis Unit, EFS (Etablissement Français du Sang), Hôpital Edouard Herriot, Lyon, France. olivier.hequet@efs.sante.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Evaluation Study
Journal Article

Language

eng

PubMed ID

19932056

Citation

Hequet, O, et al. "The First Results Demonstrating Efficiency and Safety of a Double-column Whole Blood Method of LDL-apheresis." Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis, vol. 42, no. 1, 2010, pp. 3-10.
Hequet O, Le QH, Rigal D, et al. The first results demonstrating efficiency and safety of a double-column whole blood method of LDL-apheresis. Transfus Apher Sci. 2010;42(1):3-10.
Hequet, O., Le, Q. H., Rigal, D., Mekhloufi, F., Jaeger, S., Sassolas, A., Groisne, L., & Moulin, P. (2010). The first results demonstrating efficiency and safety of a double-column whole blood method of LDL-apheresis. Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis, 42(1), 3-10. https://doi.org/10.1016/j.transci.2009.10.001
Hequet O, et al. The First Results Demonstrating Efficiency and Safety of a Double-column Whole Blood Method of LDL-apheresis. Transfus Apher Sci. 2010;42(1):3-10. PubMed PMID: 19932056.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The first results demonstrating efficiency and safety of a double-column whole blood method of LDL-apheresis. AU - Hequet,O, AU - Le,Q H, AU - Rigal,D, AU - Mekhloufi,F, AU - Jaeger,S, AU - Sassolas,A, AU - Groisne,L, AU - Moulin,P, Y1 - 2009/11/20/ PY - 2008/10/27/received PY - 2009/08/25/accepted PY - 2009/11/26/entrez PY - 2009/11/26/pubmed PY - 2010/8/21/medline SP - 3 EP - 10 JF - Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis JO - Transfus. Apher. Sci. VL - 42 IS - 1 N2 - LDL-apheresis is a treatment for familial hypercholesterolemia in addition to diet and drug therapy. In the past, LDL-apheresis techniques consisted in separating plasma from blood and adsorbing plasma LDL-C whereas recent methods remove LDL-C directly from whole blood. The whole blood system developed by Kaneka consists of a single-column (Liposorber DL-75) treatment (SCWB) but a double-column whole blood (DCWB) method has recently been developed (Liposorber DL-50 x 2). When 1.6 blood volumes (plus 1l) were processed, acute reductions of total cholesterol and LDL-C were 67.9+/-6% and 80.2+/-4.5%, respectively. The performances of the DCWB method were compared to other LDL-apheresis methods. Assessed in 10 patients, the DCWB method is more efficient than the SCWB method with higher reduction rates of LDL-C (79.7+/-4.9 vs. 68.2+/-5.0% p<0.0001) and apolipoprotein-B (79.5+/-5.4 vs. 67.4+/-5.4% p<0.0001). In a sub group of five patients having the highest LDL-C baseline levels, the LDL-C reduction rates obtained by the DCWB method are equivalent to those obtained by the conventional LDL-apheresis method consisting of preliminary plasma separation followed by plasma LDL-C adsorption and used as first line apheresis therapy (80.5+/-4.5 vs. 79.0+/-5.9%). The safety of DCWB was demonstrated in 12 patients with only a low frequency of mild and transient adverse effects (4%). In conclusion, the DCWB LDL-apheresis method provides efficient removal of LDL-C, a low level of adverse effects, and a shortened duration of the procedure. SN - 1473-0502 UR - https://www.unboundmedicine.com/medline/citation/19932056/The_first_results_demonstrating_efficiency_and_safety_of_a_double_column_whole_blood_method_of_LDL_apheresis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1473-0502(09)00169-4 DB - PRIME DP - Unbound Medicine ER -