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Effect of intradialytic versus home-based aerobic exercise training on physical function and vascular parameters in hemodialysis patients: a randomized pilot study.
Am J Kidney Dis. 2010 Jan; 55(1):88-99.AJ

Abstract

BACKGROUND

Hemodialysis patients show reduced physical function and greater risk of increased arterial stiffness because of hypertension, metabolic disturbances, and vascular calcification. Exercise interventions potentially could improve their vascular risk profile.

STUDY DESIGN

Randomized controlled pilot clinical study comparing the effects of 6 months of supervised intradialytic exercise training versus home-based exercise training or usual care on physical function and arterial stiffness in hemodialysis patients.

SETTING & PARTICIPANTS

70 hemodialysis patients from 3 renal units.

INTERVENTION

Intradialytic-exercise patients trained 3 times/wk for 6 months on a cycle ergometer and home-based-exercise patients followed a walking program to achieve the same weekly physical activity. Usual-care patients received no specific intervention.

OUTCOMES & MEASUREMENTS

Primary outcome measures were distance traveled during a 6-minute walk test and aortic pulse wave velocity. Secondary outcome measures included augmentation index (augmentation pressure as a percentage of central pulse pressure), peripheral (brachial) and central blood pressures (measured noninvasively using radial tonometry), physical activity, and self-reported physical functioning. Measurements were made at baseline and 6 months.

RESULTS

At 6 months, there were no significant differences between changes in 6-minute walk test distance (intradialytic exercise, +14%; home-based exercise, +11%; usual care, +5%), pulse wave velocity (intradialytic exercise, -4%; home-based exercise, -2%; usual care, +5%), or any secondary outcome measure.

LIMITATIONS

Lack of medication data limited the analysis of vascular parameters in this study.

CONCLUSION

There were no differences between intradialytic or home-based exercise training and usual care for either physical function or vascular parameters.

Authors+Show Affiliations

School of Human Life Sciences, University of Tasmania, Launceston, Tasmania, 7250 Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19932545

Citation

Koh, Kirsten P., et al. "Effect of Intradialytic Versus Home-based Aerobic Exercise Training On Physical Function and Vascular Parameters in Hemodialysis Patients: a Randomized Pilot Study." American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation, vol. 55, no. 1, 2010, pp. 88-99.
Koh KP, Fassett RG, Sharman JE, et al. Effect of intradialytic versus home-based aerobic exercise training on physical function and vascular parameters in hemodialysis patients: a randomized pilot study. Am J Kidney Dis. 2010;55(1):88-99.
Koh, K. P., Fassett, R. G., Sharman, J. E., Coombes, J. S., & Williams, A. D. (2010). Effect of intradialytic versus home-based aerobic exercise training on physical function and vascular parameters in hemodialysis patients: a randomized pilot study. American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation, 55(1), 88-99. https://doi.org/10.1053/j.ajkd.2009.09.025
Koh KP, et al. Effect of Intradialytic Versus Home-based Aerobic Exercise Training On Physical Function and Vascular Parameters in Hemodialysis Patients: a Randomized Pilot Study. Am J Kidney Dis. 2010;55(1):88-99. PubMed PMID: 19932545.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of intradialytic versus home-based aerobic exercise training on physical function and vascular parameters in hemodialysis patients: a randomized pilot study. AU - Koh,Kirsten P, AU - Fassett,Robert G, AU - Sharman,James E, AU - Coombes,Jeff S, AU - Williams,Andrew D, Y1 - 2009/11/22/ PY - 2009/04/21/received PY - 2009/09/14/accepted PY - 2009/11/26/entrez PY - 2009/11/26/pubmed PY - 2010/2/3/medline SP - 88 EP - 99 JF - American journal of kidney diseases : the official journal of the National Kidney Foundation JO - Am. J. Kidney Dis. VL - 55 IS - 1 N2 - BACKGROUND: Hemodialysis patients show reduced physical function and greater risk of increased arterial stiffness because of hypertension, metabolic disturbances, and vascular calcification. Exercise interventions potentially could improve their vascular risk profile. STUDY DESIGN: Randomized controlled pilot clinical study comparing the effects of 6 months of supervised intradialytic exercise training versus home-based exercise training or usual care on physical function and arterial stiffness in hemodialysis patients. SETTING & PARTICIPANTS: 70 hemodialysis patients from 3 renal units. INTERVENTION: Intradialytic-exercise patients trained 3 times/wk for 6 months on a cycle ergometer and home-based-exercise patients followed a walking program to achieve the same weekly physical activity. Usual-care patients received no specific intervention. OUTCOMES & MEASUREMENTS: Primary outcome measures were distance traveled during a 6-minute walk test and aortic pulse wave velocity. Secondary outcome measures included augmentation index (augmentation pressure as a percentage of central pulse pressure), peripheral (brachial) and central blood pressures (measured noninvasively using radial tonometry), physical activity, and self-reported physical functioning. Measurements were made at baseline and 6 months. RESULTS: At 6 months, there were no significant differences between changes in 6-minute walk test distance (intradialytic exercise, +14%; home-based exercise, +11%; usual care, +5%), pulse wave velocity (intradialytic exercise, -4%; home-based exercise, -2%; usual care, +5%), or any secondary outcome measure. LIMITATIONS: Lack of medication data limited the analysis of vascular parameters in this study. CONCLUSION: There were no differences between intradialytic or home-based exercise training and usual care for either physical function or vascular parameters. SN - 1523-6838 UR - https://www.unboundmedicine.com/medline/citation/19932545/Effect_of_intradialytic_versus_home_based_aerobic_exercise_training_on_physical_function_and_vascular_parameters_in_hemodialysis_patients:_a_randomized_pilot_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0272-6386(09)01311-0 DB - PRIME DP - Unbound Medicine ER -