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Baseline alcohol consumption, type of alcoholic beverage and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition-Norfolk study.

Abstract

Excessive alcohol consumption has been associated with increased risk of colorectal cancer (CRC). However, the effect of modest alcohol consumption or of particular types of beverages on CRC risk remains unclear. We examined whether consumption of total alcohol or specific types of alcoholic beverages relate to overall or site-specific CRC risk in a prospective population study of 24,244 participants and 407 incident CRC cases after 11 years of follow-up. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models. Consumption of specific alcoholic beverages at baseline was collected using a detailed health and lifestyle questionnaire. Total alcohol consumption was not associated with CRC risk before or after adjustment for age, sex, weight, height, and smoking status (HR: 0.80, 95% CI: 0.51-1.26 for alcohol consumption of > or =21 units/week compared with non-drinkers), and further adjustment for education level, exercise, family history of CRC, and dietary factors did not significantly alter the risk estimates (HR: 0.70, 95% CI: 0.44-1.13). No significant associations were observed between consumption of specific alcoholic beverages (beer, sherry, or spirits) and CRC risk when compared with non-drinkers after adjustment for lifestyle and dietary factors. Daily consumption of > or =1 unit of wine appeared inversely related to CRC risk (HR: 0.61, 95% CI: 0.40-0.94). No evidence was found for sex-specific relationships, and further exclusion of cases incident within 3 years of baseline did not change the associations observed. In this population-based UK cohort, we did not find any significant adverse effect of alcohol over the moderate range of intake on colorectal cancer risk.

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  • Authors+Show Affiliations

    ,

    Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK. jyp23@medschl.cam.ac.uk

    , , , , ,

    Source

    Cancer epidemiology 33:5 2009 Nov pg 347-54

    MeSH

    Alcohol Drinking
    Alcoholic Beverages
    Colorectal Neoplasms
    Female
    Humans
    Male
    Risk Factors
    Surveys and Questionnaires
    United Kingdom

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    19932648

    Citation

    Park, Jin Young, et al. "Baseline Alcohol Consumption, Type of Alcoholic Beverage and Risk of Colorectal Cancer in the European Prospective Investigation Into Cancer and Nutrition-Norfolk Study." Cancer Epidemiology, vol. 33, no. 5, 2009, pp. 347-54.
    Park JY, Mitrou PN, Dahm CC, et al. Baseline alcohol consumption, type of alcoholic beverage and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition-Norfolk study. Cancer Epidemiol. 2009;33(5):347-54.
    Park, J. Y., Mitrou, P. N., Dahm, C. C., Luben, R. N., Wareham, N. J., Khaw, K. T., & Rodwell, S. A. (2009). Baseline alcohol consumption, type of alcoholic beverage and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition-Norfolk study. Cancer Epidemiology, 33(5), pp. 347-54. doi:10.1016/j.canep.2009.10.015.
    Park JY, et al. Baseline Alcohol Consumption, Type of Alcoholic Beverage and Risk of Colorectal Cancer in the European Prospective Investigation Into Cancer and Nutrition-Norfolk Study. Cancer Epidemiol. 2009;33(5):347-54. PubMed PMID: 19932648.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Baseline alcohol consumption, type of alcoholic beverage and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition-Norfolk study. AU - Park,Jin Young, AU - Mitrou,Panagiota N, AU - Dahm,Christina C, AU - Luben,Robert N, AU - Wareham,Nicholas J, AU - Khaw,Kay-Tee, AU - Rodwell,Sheila A, Y1 - 2009/11/22/ PY - 2009/07/20/received PY - 2009/10/27/revised PY - 2009/10/30/accepted PY - 2009/11/26/entrez PY - 2009/11/26/pubmed PY - 2010/2/3/medline SP - 347 EP - 54 JF - Cancer epidemiology JO - Cancer Epidemiol VL - 33 IS - 5 N2 - Excessive alcohol consumption has been associated with increased risk of colorectal cancer (CRC). However, the effect of modest alcohol consumption or of particular types of beverages on CRC risk remains unclear. We examined whether consumption of total alcohol or specific types of alcoholic beverages relate to overall or site-specific CRC risk in a prospective population study of 24,244 participants and 407 incident CRC cases after 11 years of follow-up. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models. Consumption of specific alcoholic beverages at baseline was collected using a detailed health and lifestyle questionnaire. Total alcohol consumption was not associated with CRC risk before or after adjustment for age, sex, weight, height, and smoking status (HR: 0.80, 95% CI: 0.51-1.26 for alcohol consumption of > or =21 units/week compared with non-drinkers), and further adjustment for education level, exercise, family history of CRC, and dietary factors did not significantly alter the risk estimates (HR: 0.70, 95% CI: 0.44-1.13). No significant associations were observed between consumption of specific alcoholic beverages (beer, sherry, or spirits) and CRC risk when compared with non-drinkers after adjustment for lifestyle and dietary factors. Daily consumption of > or =1 unit of wine appeared inversely related to CRC risk (HR: 0.61, 95% CI: 0.40-0.94). No evidence was found for sex-specific relationships, and further exclusion of cases incident within 3 years of baseline did not change the associations observed. In this population-based UK cohort, we did not find any significant adverse effect of alcohol over the moderate range of intake on colorectal cancer risk. SN - 1877-783X UR - https://www.unboundmedicine.com/medline/citation/19932648/Baseline_alcohol_consumption_type_of_alcoholic_beverage_and_risk_of_colorectal_cancer_in_the_European_Prospective_Investigation_into_Cancer_and_Nutrition_Norfolk_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1877-7821(09)00144-1 DB - PRIME DP - Unbound Medicine ER -