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Green tea, black tea, and epigallocatechin modify body composition, improve glucose tolerance, and differentially alter metabolic gene expression in rats fed a high-fat diet.
Nutr Res. 2009 Nov; 29(11):784-93.NR

Abstract

The mechanisms of how tea and epigallocatechin-3-gallate (EGCG) lower body fat are not completely understood. This study investigated long-term administration of green tea (GT), black tea (BT), or isolated EGCG (1 mg/kg per day) on body composition, glucose tolerance, and gene expression related to energy metabolism and lipid homeostasis; it was hypothesized that all treatments would improve the indicators of metabolic syndrome. Rats were fed a 15% fat diet for 6 months from 4 weeks of age and were supplied GT, BT, EGCG, or water. GT and BT reduced body fat, whereas GT and EGCG increased lean mass. At 16 weeks GT, BT, and EGCG improved glucose tolerance. In the liver, GT and BT increased the expression of genes involved in fatty acid synthesis (SREBP-1c, FAS, MCD, ACC) and oxidation (PPAR-alpha, CPT-1, ACO); however, EGCG had no effect. In perirenal fat, genes that mediate adipocyte differentiation were suppressed by GT (Pref-1, C/EBP-beta, and PPAR-gamma) and BT (C/EBP-beta), while decreasing LPL, HSL, and UCP-2 expression; EGCG increased expression of UCP-2 and PPAR-gamma genes. Liver triacylglycerol content was unchanged. The results suggest that GT and BT suppressed adipocyte differentiation and fatty acid uptake into adipose tissue, while increasing fat synthesis and oxidation by the liver, without inducing hepatic fat accumulation. In contrast, EGCG increased markers of thermogenesis and differentiation in adipose tissue, while having no effect on liver or muscle tissues at this dose. These results show novel and separate mechanisms by which tea and EGCG may improve glucose tolerance and support a role for these compounds in obesity prevention.

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Authors+Show Affiliations

Chen N
Department of Optometry and Vision Sciences, University of Melbourne, Australia.
Bezzina R
No affiliation info available
Hinch E
No affiliation info available
Lewandowski PA
No affiliation info available
Cameron-Smith D
No affiliation info available
Mathai ML
No affiliation info available
Jois M
No affiliation info available
Sinclair AJ
No affiliation info available
Begg DP
No affiliation info available
Wark JD
No affiliation info available
Weisinger HS
No affiliation info available
Weisinger RS
No affiliation info available

MeSH

AdipocytesAdipose TissueAnimalsAntioxidantsBiomarkersBody CompositionCamellia sinensisCatechinCell DifferentiationDiet, AtherogenicDietary FatsFatty AcidsGene ExpressionGene Expression RegulationGlucose IntoleranceLiverMaleMetabolic SyndromeMuscle, SkeletalPhytotherapyPlant ExtractsRNA, MessengerRatsRats, Sprague-DawleyTeaThermogenesis

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19932867

Citation

Chen, Nora, et al. "Green Tea, Black Tea, and Epigallocatechin Modify Body Composition, Improve Glucose Tolerance, and Differentially Alter Metabolic Gene Expression in Rats Fed a High-fat Diet." Nutrition Research (New York, N.Y.), vol. 29, no. 11, 2009, pp. 784-93.
Chen N, Bezzina R, Hinch E, et al. Green tea, black tea, and epigallocatechin modify body composition, improve glucose tolerance, and differentially alter metabolic gene expression in rats fed a high-fat diet. Nutr Res. 2009;29(11):784-93.
Chen, N., Bezzina, R., Hinch, E., Lewandowski, P. A., Cameron-Smith, D., Mathai, M. L., Jois, M., Sinclair, A. J., Begg, D. P., Wark, J. D., Weisinger, H. S., & Weisinger, R. S. (2009). Green tea, black tea, and epigallocatechin modify body composition, improve glucose tolerance, and differentially alter metabolic gene expression in rats fed a high-fat diet. Nutrition Research (New York, N.Y.), 29(11), 784-93. https://doi.org/10.1016/j.nutres.2009.10.003
Chen N, et al. Green Tea, Black Tea, and Epigallocatechin Modify Body Composition, Improve Glucose Tolerance, and Differentially Alter Metabolic Gene Expression in Rats Fed a High-fat Diet. Nutr Res. 2009;29(11):784-93. PubMed PMID: 19932867.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Green tea, black tea, and epigallocatechin modify body composition, improve glucose tolerance, and differentially alter metabolic gene expression in rats fed a high-fat diet. AU - Chen,Nora, AU - Bezzina,Rebecca, AU - Hinch,Edward, AU - Lewandowski,Paul A, AU - Cameron-Smith,David, AU - Mathai,Michael L, AU - Jois,Markandeya, AU - Sinclair,Andrew J, AU - Begg,Denovan P, AU - Wark,John D, AU - Weisinger,Harrison S, AU - Weisinger,Richard S, PY - 2009/08/26/received PY - 2009/10/07/revised PY - 2009/10/07/accepted PY - 2009/11/26/entrez PY - 2009/11/26/pubmed PY - 2010/3/12/medline SP - 784 EP - 93 JF - Nutrition research (New York, N.Y.) JO - Nutr Res VL - 29 IS - 11 N2 - The mechanisms of how tea and epigallocatechin-3-gallate (EGCG) lower body fat are not completely understood. This study investigated long-term administration of green tea (GT), black tea (BT), or isolated EGCG (1 mg/kg per day) on body composition, glucose tolerance, and gene expression related to energy metabolism and lipid homeostasis; it was hypothesized that all treatments would improve the indicators of metabolic syndrome. Rats were fed a 15% fat diet for 6 months from 4 weeks of age and were supplied GT, BT, EGCG, or water. GT and BT reduced body fat, whereas GT and EGCG increased lean mass. At 16 weeks GT, BT, and EGCG improved glucose tolerance. In the liver, GT and BT increased the expression of genes involved in fatty acid synthesis (SREBP-1c, FAS, MCD, ACC) and oxidation (PPAR-alpha, CPT-1, ACO); however, EGCG had no effect. In perirenal fat, genes that mediate adipocyte differentiation were suppressed by GT (Pref-1, C/EBP-beta, and PPAR-gamma) and BT (C/EBP-beta), while decreasing LPL, HSL, and UCP-2 expression; EGCG increased expression of UCP-2 and PPAR-gamma genes. Liver triacylglycerol content was unchanged. The results suggest that GT and BT suppressed adipocyte differentiation and fatty acid uptake into adipose tissue, while increasing fat synthesis and oxidation by the liver, without inducing hepatic fat accumulation. In contrast, EGCG increased markers of thermogenesis and differentiation in adipose tissue, while having no effect on liver or muscle tissues at this dose. These results show novel and separate mechanisms by which tea and EGCG may improve glucose tolerance and support a role for these compounds in obesity prevention. SN - 1879-0739 UR - https://www.unboundmedicine.com/medline/citation/19932867/Green_tea_black_tea_and_epigallocatechin_modify_body_composition_improve_glucose_tolerance_and_differentially_alter_metabolic_gene_expression_in_rats_fed_a_high_fat_diet_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0271-5317(09)00178-X DB - PRIME DP - Unbound Medicine ER -