Tags

Type your tag names separated by a space and hit enter

Recurrent disease following liver transplantation for nonalcoholic steatohepatitis cirrhosis.
Liver Transpl. 2009 Dec; 15(12):1843-51.LT

Abstract

Recurrence of the original disease following liver transplantation is not uncommon and can lead to graft failure. There are limited data on recurrent fatty liver disease following liver transplantation. The aim of this study was to determine the incidence of recurrent fatty liver disease in patients with biopsy-proven nonalcoholic steatohepatitis, its effect on survival, and whether there are any predictive factors for recurrence. We analyzed patients undergoing liver transplantation for nonalcoholic steatohepatitis cirrhosis from 1997 to 2008 at a single center. Patients undergoing transplantation for cholestatic disease, alcohol, hepatitis C, or cryptogenic cirrhosis were controls. Ninety-eight patients underwent transplantation for nonalcoholic steatohepatitis cirrhosis. Recurrent fatty liver disease was seen in 70%, 25% had recurrent nonalcoholic steatohepatitis, and 18% had stage II/IV or greater fibrosis at a mean of 18 months. No patients with recurrent nonalcoholic steatohepatitis developed graft failure or required retransplantation at a follow-up of 3 years. No recipient or donor factors were associated with disease recurrence, although patients with recurrent nonalcoholic steatohepatitis had a higher incidence of diabetes, weight gain, and dyslipidemia at the time of diagnosis of recurrence. One-third of patients with recurrent nonalcoholic steatohepatitis had normal liver enzymes at the time of diagnosis post-transplantation. In conclusion, recurrent fatty liver disease is common following liver transplantation for nonalcoholic steatohepatitis cirrhosis but does not lead to early allograft failure. Recurrent nonalcoholic steatohepatitis can occur despite normal liver enzymes, and features of metabolic syndrome are associated with disease recurrence.

Authors+Show Affiliations

Division of Gastroenterology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19938117

Citation

Malik, Shahid M., et al. "Recurrent Disease Following Liver Transplantation for Nonalcoholic Steatohepatitis Cirrhosis." Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, vol. 15, no. 12, 2009, pp. 1843-51.
Malik SM, Devera ME, Fontes P, et al. Recurrent disease following liver transplantation for nonalcoholic steatohepatitis cirrhosis. Liver Transpl. 2009;15(12):1843-51.
Malik, S. M., Devera, M. E., Fontes, P., Shaikh, O., Sasatomi, E., & Ahmad, J. (2009). Recurrent disease following liver transplantation for nonalcoholic steatohepatitis cirrhosis. Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 15(12), 1843-51. https://doi.org/10.1002/lt.21943
Malik SM, et al. Recurrent Disease Following Liver Transplantation for Nonalcoholic Steatohepatitis Cirrhosis. Liver Transpl. 2009;15(12):1843-51. PubMed PMID: 19938117.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Recurrent disease following liver transplantation for nonalcoholic steatohepatitis cirrhosis. AU - Malik,Shahid M, AU - Devera,Michael E, AU - Fontes,Paulo, AU - Shaikh,Obaid, AU - Sasatomi,Eizaburo, AU - Ahmad,Jawad, PY - 2009/11/26/entrez PY - 2009/11/26/pubmed PY - 2010/1/29/medline SP - 1843 EP - 51 JF - Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society JO - Liver Transpl. VL - 15 IS - 12 N2 - Recurrence of the original disease following liver transplantation is not uncommon and can lead to graft failure. There are limited data on recurrent fatty liver disease following liver transplantation. The aim of this study was to determine the incidence of recurrent fatty liver disease in patients with biopsy-proven nonalcoholic steatohepatitis, its effect on survival, and whether there are any predictive factors for recurrence. We analyzed patients undergoing liver transplantation for nonalcoholic steatohepatitis cirrhosis from 1997 to 2008 at a single center. Patients undergoing transplantation for cholestatic disease, alcohol, hepatitis C, or cryptogenic cirrhosis were controls. Ninety-eight patients underwent transplantation for nonalcoholic steatohepatitis cirrhosis. Recurrent fatty liver disease was seen in 70%, 25% had recurrent nonalcoholic steatohepatitis, and 18% had stage II/IV or greater fibrosis at a mean of 18 months. No patients with recurrent nonalcoholic steatohepatitis developed graft failure or required retransplantation at a follow-up of 3 years. No recipient or donor factors were associated with disease recurrence, although patients with recurrent nonalcoholic steatohepatitis had a higher incidence of diabetes, weight gain, and dyslipidemia at the time of diagnosis of recurrence. One-third of patients with recurrent nonalcoholic steatohepatitis had normal liver enzymes at the time of diagnosis post-transplantation. In conclusion, recurrent fatty liver disease is common following liver transplantation for nonalcoholic steatohepatitis cirrhosis but does not lead to early allograft failure. Recurrent nonalcoholic steatohepatitis can occur despite normal liver enzymes, and features of metabolic syndrome are associated with disease recurrence. SN - 1527-6473 UR - https://www.unboundmedicine.com/medline/citation/19938117/Recurrent_disease_following_liver_transplantation_for_nonalcoholic_steatohepatitis_cirrhosis_ L2 - https://doi.org/10.1002/lt.21943 DB - PRIME DP - Unbound Medicine ER -