Tags

Type your tag names separated by a space and hit enter

[The morphology of the immune system in opiomania, cannabism, and polynarcotism].
Arkh Patol 2009 Sep-Oct; 71(5):35-40AP

Abstract

The organs of the immune system were morphologically and immunohistochemically studied in chronic opiomania (n = 219), cannabism (n = 22), and polynarcotism (n = 69) after excluding HIV-infected patients. In opiomania, immune disorders were identified in 98.6% of cases. These immune disorders differ according to their stage and characterize by the inversion of the T-helper/T-suppressor index, the reductions in the proliferative activity of lymphocytes and the production of immunoglobulins, atrophy of the thymus and T zones, and, in 37.4% of cases, persistent follicular hyperplasia of B zones with the impaired architectonics of lymphoid follicles. It is a cause of generalized lymphadenopathy and splenomegaly, which are similar to those observed in HIV infection. Infection with hepatitis B and C viruses enhances thymus and T-zone atrophy, but B-tone hyperplasia particularly in the lymph nodes of the hepatic hilum and spleen. In cannabism, the morphological signs of immunodeficiency were revealed only in 13.6% of the dead and there was no inversion of the T-helper/T-suppressor index. In polynarcotism, the involvement of immune organs is most severe and similar to that seen in opiomania.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

rus

PubMed ID

19938701

Citation

Zaĭrat'iants, O V., and A B. Gasanov. "[The Morphology of the Immune System in Opiomania, Cannabism, and Polynarcotism]." Arkhiv Patologii, vol. 71, no. 5, 2009, pp. 35-40.
Zaĭrat'iants OV, Gasanov AB. [The morphology of the immune system in opiomania, cannabism, and polynarcotism]. Arkh Patol. 2009;71(5):35-40.
Zaĭrat'iants, O. V., & Gasanov, A. B. (2009). [The morphology of the immune system in opiomania, cannabism, and polynarcotism]. Arkhiv Patologii, 71(5), pp. 35-40.
Zaĭrat'iants OV, Gasanov AB. [The Morphology of the Immune System in Opiomania, Cannabism, and Polynarcotism]. Arkh Patol. 2009;71(5):35-40. PubMed PMID: 19938701.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The morphology of the immune system in opiomania, cannabism, and polynarcotism]. AU - Zaĭrat'iants,O V, AU - Gasanov,A B, PY - 2009/11/27/entrez PY - 2009/11/27/pubmed PY - 2009/12/24/medline SP - 35 EP - 40 JF - Arkhiv patologii JO - Arkh. Patol. VL - 71 IS - 5 N2 - The organs of the immune system were morphologically and immunohistochemically studied in chronic opiomania (n = 219), cannabism (n = 22), and polynarcotism (n = 69) after excluding HIV-infected patients. In opiomania, immune disorders were identified in 98.6% of cases. These immune disorders differ according to their stage and characterize by the inversion of the T-helper/T-suppressor index, the reductions in the proliferative activity of lymphocytes and the production of immunoglobulins, atrophy of the thymus and T zones, and, in 37.4% of cases, persistent follicular hyperplasia of B zones with the impaired architectonics of lymphoid follicles. It is a cause of generalized lymphadenopathy and splenomegaly, which are similar to those observed in HIV infection. Infection with hepatitis B and C viruses enhances thymus and T-zone atrophy, but B-tone hyperplasia particularly in the lymph nodes of the hepatic hilum and spleen. In cannabism, the morphological signs of immunodeficiency were revealed only in 13.6% of the dead and there was no inversion of the T-helper/T-suppressor index. In polynarcotism, the involvement of immune organs is most severe and similar to that seen in opiomania. SN - 0004-1955 UR - https://www.unboundmedicine.com/medline/citation/19938701/full_citation/[The_morphology_of_t L2 - https://medlineplus.gov/marijuana.html DB - PRIME DP - Unbound Medicine ER -