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[The morphology of the immune system in opiomania, cannabism, and polynarcotism].

Abstract

The organs of the immune system were morphologically and immunohistochemically studied in chronic opiomania (n = 219), cannabism (n = 22), and polynarcotism (n = 69) after excluding HIV-infected patients. In opiomania, immune disorders were identified in 98.6% of cases. These immune disorders differ according to their stage and characterize by the inversion of the T-helper/T-suppressor index, the reductions in the proliferative activity of lymphocytes and the production of immunoglobulins, atrophy of the thymus and T zones, and, in 37.4% of cases, persistent follicular hyperplasia of B zones with the impaired architectonics of lymphoid follicles. It is a cause of generalized lymphadenopathy and splenomegaly, which are similar to those observed in HIV infection. Infection with hepatitis B and C viruses enhances thymus and T-zone atrophy, but B-tone hyperplasia particularly in the lymph nodes of the hepatic hilum and spleen. In cannabism, the morphological signs of immunodeficiency were revealed only in 13.6% of the dead and there was no inversion of the T-helper/T-suppressor index. In polynarcotism, the involvement of immune organs is most severe and similar to that seen in opiomania.

Authors

,

Source

Arkhiv patologii 71:5 pg 35-40

MeSH

Adolescent
Adult
Antibody Formation
CD8-Positive T-Lymphocytes
Female
Humans
Immune System Diseases
Male
Marijuana Abuse
Middle Aged
Opioid-Related Disorders
T-Lymphocytes, Helper-Inducer
Thymus Gland
Virus Diseases

Pub Type(s)

English Abstract
Journal Article

Language

rus

PubMed ID

19938701

Citation

TY - JOUR T1 - [The morphology of the immune system in opiomania, cannabism, and polynarcotism]. AU - Zaĭrat'iants,O V, AU - Gasanov,A B, PY - 2009/11/27/entrez PY - 2009/11/27/pubmed PY - 2009/12/24/medline SP - 35 EP - 40 JF - Arkhiv patologii JO - Arkh. Patol. VL - 71 IS - 5 N2 - The organs of the immune system were morphologically and immunohistochemically studied in chronic opiomania (n = 219), cannabism (n = 22), and polynarcotism (n = 69) after excluding HIV-infected patients. In opiomania, immune disorders were identified in 98.6% of cases. These immune disorders differ according to their stage and characterize by the inversion of the T-helper/T-suppressor index, the reductions in the proliferative activity of lymphocytes and the production of immunoglobulins, atrophy of the thymus and T zones, and, in 37.4% of cases, persistent follicular hyperplasia of B zones with the impaired architectonics of lymphoid follicles. It is a cause of generalized lymphadenopathy and splenomegaly, which are similar to those observed in HIV infection. Infection with hepatitis B and C viruses enhances thymus and T-zone atrophy, but B-tone hyperplasia particularly in the lymph nodes of the hepatic hilum and spleen. In cannabism, the morphological signs of immunodeficiency were revealed only in 13.6% of the dead and there was no inversion of the T-helper/T-suppressor index. In polynarcotism, the involvement of immune organs is most severe and similar to that seen in opiomania. SN - 0004-1955 UR - https://www.unboundmedicine.com/medline/citation/19938701/full_citation/[The_morphology_of_the_immune_system_in_opiomania_cannabism_and_polynarcotism] L2 - https://medlineplus.gov/marijuana.html ER -