Tags

Type your tag names separated by a space and hit enter

Non-soy legume consumption lowers cholesterol levels: a meta-analysis of randomized controlled trials.

Abstract

BACKGROUND AND AIMS

Studies evaluating the effect of legume consumption on cholesterol have focused on soybeans, however non-soy legumes, such as a variety of beans, peas, and some seeds, are commonly consumed in Western countries. We conducted a meta-analysis of randomized controlled trials evaluating the effects of non-soy legume consumption on blood lipids.

METHODS AND RESULTS

Studies were retrieved by searching MEDLINE (from January 1966 through July 2009), EMBASE (from January 1980 to July 2009), and the Cochrane Collaboration's Central Register of Controlled Clinical Trials using the following terms as medical subject headings and keywords: fabaceae not soybeans not isoflavones and diet or dietary fiber and cholesterol or hypercholesterolemia or triglycerides or cardiovascular diseases. Bibliographies of all retrieved articles were also searched. From 140 relevant reports, 10 randomized clinical trials were selected which compared a non-soy legume diet to control, had a minimum duration of 3 weeks, and reported blood lipid changes during intervention and control. Data on sample size, participant characteristics, study design, intervention methods, duration, and treatment results were independently abstracted by 2 investigators using a standardized protocol. Data from 10 trials representing 268 participants were examined using a random-effects model. Pooled mean net change in total cholesterol for those treated with a legume diet compared to control was -11.8 mg/dL (95% confidence interval [CI], -16.1 to -7.5); mean net change in low-density lipoprotein cholesterol was -8.0mg/dL (95% CI, -11.4 to -4.6).

CONCLUSION

These results indicate that a diet rich in legumes other than soy decreases total and LDL cholesterol.

Links

  • PMC Free PDF
  • PMC Free Full Text
  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA. lbazzano@tulane.edu

    , , ,

    Source

    MeSH

    Adolescent
    Adult
    Aged
    Cardiovascular Diseases
    Cholesterol, HDL
    Cholesterol, LDL
    Confidence Intervals
    Diet
    Fabaceae
    Female
    Humans
    Hypercholesterolemia
    Isoflavones
    Linear Models
    Male
    Middle Aged
    Plant Proteins, Dietary
    Randomized Controlled Trials as Topic
    Triglycerides
    Young Adult

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    19939654

    Citation

    Bazzano, L A., et al. "Non-soy Legume Consumption Lowers Cholesterol Levels: a Meta-analysis of Randomized Controlled Trials." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 21, no. 2, 2011, pp. 94-103.
    Bazzano LA, Thompson AM, Tees MT, et al. Non-soy legume consumption lowers cholesterol levels: a meta-analysis of randomized controlled trials. Nutr Metab Cardiovasc Dis. 2011;21(2):94-103.
    Bazzano, L. A., Thompson, A. M., Tees, M. T., Nguyen, C. H., & Winham, D. M. (2011). Non-soy legume consumption lowers cholesterol levels: a meta-analysis of randomized controlled trials. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 21(2), pp. 94-103. doi:10.1016/j.numecd.2009.08.012.
    Bazzano LA, et al. Non-soy Legume Consumption Lowers Cholesterol Levels: a Meta-analysis of Randomized Controlled Trials. Nutr Metab Cardiovasc Dis. 2011;21(2):94-103. PubMed PMID: 19939654.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Non-soy legume consumption lowers cholesterol levels: a meta-analysis of randomized controlled trials. AU - Bazzano,L A, AU - Thompson,A M, AU - Tees,M T, AU - Nguyen,C H, AU - Winham,D M, Y1 - 2009/11/25/ PY - 2009/04/22/received PY - 2009/08/14/revised PY - 2009/08/20/accepted PY - 2009/11/27/entrez PY - 2009/11/27/pubmed PY - 2011/5/20/medline SP - 94 EP - 103 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 21 IS - 2 N2 - BACKGROUND AND AIMS: Studies evaluating the effect of legume consumption on cholesterol have focused on soybeans, however non-soy legumes, such as a variety of beans, peas, and some seeds, are commonly consumed in Western countries. We conducted a meta-analysis of randomized controlled trials evaluating the effects of non-soy legume consumption on blood lipids. METHODS AND RESULTS: Studies were retrieved by searching MEDLINE (from January 1966 through July 2009), EMBASE (from January 1980 to July 2009), and the Cochrane Collaboration's Central Register of Controlled Clinical Trials using the following terms as medical subject headings and keywords: fabaceae not soybeans not isoflavones and diet or dietary fiber and cholesterol or hypercholesterolemia or triglycerides or cardiovascular diseases. Bibliographies of all retrieved articles were also searched. From 140 relevant reports, 10 randomized clinical trials were selected which compared a non-soy legume diet to control, had a minimum duration of 3 weeks, and reported blood lipid changes during intervention and control. Data on sample size, participant characteristics, study design, intervention methods, duration, and treatment results were independently abstracted by 2 investigators using a standardized protocol. Data from 10 trials representing 268 participants were examined using a random-effects model. Pooled mean net change in total cholesterol for those treated with a legume diet compared to control was -11.8 mg/dL (95% confidence interval [CI], -16.1 to -7.5); mean net change in low-density lipoprotein cholesterol was -8.0mg/dL (95% CI, -11.4 to -4.6). CONCLUSION: These results indicate that a diet rich in legumes other than soy decreases total and LDL cholesterol. SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/19939654/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-4753(09)00211-7 DB - PRIME DP - Unbound Medicine ER -