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Effects of cannabidiol on amphetamine-induced oxidative stress generation in an animal model of mania.
J Psychopharmacol 2011; 25(2):274-80JP

Abstract

Cannabidiol (CBD), a Cannabis sativa constituent, may present a pharmacological profile similar to mood stabilizing drugs, in addition to anti-oxidative and neuroprotective properties. The present study aims to directly investigate the effects of CBD in an animal model of mania induced by D-amphetamine (D-AMPH). In the first model (reversal treatment), rats received saline or D-AMPH (2 mg/kg) once daily intraperitoneal (i.p.) for 14 days, and from the 8th to the 14th day, they were treated with saline or CBD (15, 30 or 60 mg/kg) i.p. twice a day. In the second model (prevention treatment), rats were pretreated with saline or CBD (15, 30, or 60 mg/kg) regime i.p. twice a day, and from the 8th to the 14th day, they also received saline or D-AMPH i.p. once daily. In the hippocampus CBD (15 mg/kg) reversed the d-AMPH-induced damage and increased (30 mg/kg) brain-derived neurotrophic factor (BDNF) expression. In the second experiment, CBD (30 or 60 mg/kg) prevented the D-AMPH-induced formation of carbonyl group in the prefrontal cortex. In the hippocampus and striatum the D-AMPH-induced damage was prevented by CBD (15, 30 or 60 mg/kg). At both treatments CBD did not present any effect against d-AMPH-induced hyperactivity. In conclusion, we could not observe effects on locomotion, but CBD protect against d-AMPH-induced oxidative protein damage and increased BDNF levels in the reversal model and these effects vary depending on the brain regions evaluated and doses of CBD administered.

Authors+Show Affiliations

Laboratório de Neurociências, Programa de Pós-Graduação em Ciências da Saúde, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brasil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19939866

Citation

Valvassori, Samira S., et al. "Effects of Cannabidiol On Amphetamine-induced Oxidative Stress Generation in an Animal Model of Mania." Journal of Psychopharmacology (Oxford, England), vol. 25, no. 2, 2011, pp. 274-80.
Valvassori SS, Elias G, de Souza B, et al. Effects of cannabidiol on amphetamine-induced oxidative stress generation in an animal model of mania. J Psychopharmacol (Oxford). 2011;25(2):274-80.
Valvassori, S. S., Elias, G., de Souza, B., Petronilho, F., Dal-Pizzol, F., Kapczinski, F., ... Crippa, J. A. (2011). Effects of cannabidiol on amphetamine-induced oxidative stress generation in an animal model of mania. Journal of Psychopharmacology (Oxford, England), 25(2), pp. 274-80. doi:10.1177/0269881109106925.
Valvassori SS, et al. Effects of Cannabidiol On Amphetamine-induced Oxidative Stress Generation in an Animal Model of Mania. J Psychopharmacol (Oxford). 2011;25(2):274-80. PubMed PMID: 19939866.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of cannabidiol on amphetamine-induced oxidative stress generation in an animal model of mania. AU - Valvassori,Samira S, AU - Elias,Guilherme, AU - de Souza,Bruna, AU - Petronilho,Fabrícia, AU - Dal-Pizzol,Felipe, AU - Kapczinski,Flávio, AU - Trzesniak,Clarissa, AU - Tumas,Vitor, AU - Dursun,Serdar, AU - Chagas,Marcos Hortes Nisihara, AU - Hallak,Jaime E C, AU - Zuardi,Antonio W, AU - Quevedo,João, AU - Crippa,José A S, Y1 - 2009/11/25/ PY - 2009/11/27/entrez PY - 2009/11/27/pubmed PY - 2011/5/12/medline SP - 274 EP - 80 JF - Journal of psychopharmacology (Oxford, England) JO - J. Psychopharmacol. (Oxford) VL - 25 IS - 2 N2 - Cannabidiol (CBD), a Cannabis sativa constituent, may present a pharmacological profile similar to mood stabilizing drugs, in addition to anti-oxidative and neuroprotective properties. The present study aims to directly investigate the effects of CBD in an animal model of mania induced by D-amphetamine (D-AMPH). In the first model (reversal treatment), rats received saline or D-AMPH (2 mg/kg) once daily intraperitoneal (i.p.) for 14 days, and from the 8th to the 14th day, they were treated with saline or CBD (15, 30 or 60 mg/kg) i.p. twice a day. In the second model (prevention treatment), rats were pretreated with saline or CBD (15, 30, or 60 mg/kg) regime i.p. twice a day, and from the 8th to the 14th day, they also received saline or D-AMPH i.p. once daily. In the hippocampus CBD (15 mg/kg) reversed the d-AMPH-induced damage and increased (30 mg/kg) brain-derived neurotrophic factor (BDNF) expression. In the second experiment, CBD (30 or 60 mg/kg) prevented the D-AMPH-induced formation of carbonyl group in the prefrontal cortex. In the hippocampus and striatum the D-AMPH-induced damage was prevented by CBD (15, 30 or 60 mg/kg). At both treatments CBD did not present any effect against d-AMPH-induced hyperactivity. In conclusion, we could not observe effects on locomotion, but CBD protect against d-AMPH-induced oxidative protein damage and increased BDNF levels in the reversal model and these effects vary depending on the brain regions evaluated and doses of CBD administered. SN - 1461-7285 UR - https://www.unboundmedicine.com/medline/citation/19939866/Effects_of_cannabidiol_on_amphetamine_induced_oxidative_stress_generation_in_an_animal_model_of_mania_ L2 - http://journals.sagepub.com/doi/full/10.1177/0269881109106925?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -